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Novel, highly effective and selective anticancer metallodrugs

Total Cost €


EC-Contrib. €






 TSPO METALLODRUGS project word cloud

Explore the words cloud of the TSPO METALLODRUGS project. It provides you a very rough idea of what is the project "TSPO METALLODRUGS" about.

biomedical    24    area    background    dr    tumour    proposes    months    drug    expand    deepen    techniques    postdoctoral    leila    chemistry    performed    structure    group    cell    tabrizi    complexes    university    transferable    inhibition    training    personal    protein    simultaneously    carrier    anticancer    metal    selective    national    mitochondrial    professional    excellent    independent    biological    synthesis    vitro    collaborations    receiving    ligand    researcher    carry    industrial    synthetic    skills    enter    nui    overexpressed    drugs    strategically    scientific    types    mentoring    branches    thioredoxin    academic    progression    inhibitor    ireland    government    cancer    recognize    awarded    mode    gold    induce    reductase    fellowship    relationships    proteins    strength    iranian    synergistic    erxleben    release    translocator    intracellular    candidates    understand    galway    designed    binding    action    biochemistry    medicinal    maturity    manner    death   

Project "TSPO METALLODRUGS" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00


 Project objective

Dr. Leila Tabrizi, an Iranian national, is making an application to this programme to carry out a 24 months project in the area of medicinal chemistry in the group of Dr. A. Erxleben at the National University of Ireland, Galway. The objective of this proposal is the synthesis of novel gold anticancer drugs that simultaneously target two mitochondrial proteins that are associated with cancer progression. Gold(III) complexes will be designed that recognize the translocator protein which is overexpressed in various tumour types and that release the metal upon intracellular reduction to gold(I), a known inhibitor of thioredoxin reductase. Binding of the carrier ligand to the translocator protein and inhibition of thioredoxin reductase will induce cell death pathways in a synergistic manner, thus leading to highly effective and selective anticancer action. Detailed in vitro biological studies will be performed to evaluate the potential of the new anticancer drug candidates, to establish structure-activity relationships and to fully understand their mode of action. The researcher has already an excellent background in coordination chemistry and this project will allow her to deepen and expand her skills in synthetic chemistry, to enter into the biological field by receiving relevant training in cell and biological techniques and to establish important academic and industrial collaborations. The researcher who has recently been awarded a Government of Ireland Postdoctoral Fellowship proposes to carry out further research training at NUI Galway which is strategically developing strength in Biomedical Research and Cancer, one of the most important and challenging branches of Chemistry/Biochemistry in Europe. NUI Galway will also provide training in transferable skills and mentoring to the researcher. Both the scientific and personal training will contribute to her personal development and will allow her to reach professional maturity as an independent researcher.

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The information about "TSPO METALLODRUGS" are provided by the European Opendata Portal: CORDIS opendata.

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