Opendata, web and dolomites

TSPO METALLODRUGS SIGNED

Novel, highly effective and selective anticancer metallodrugs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TSPO METALLODRUGS project word cloud

Explore the words cloud of the TSPO METALLODRUGS project. It provides you a very rough idea of what is the project "TSPO METALLODRUGS" about.

government    recognize    overexpressed    personal    ligand    expand    action    excellent    mitochondrial    translocator    skills    fellowship    independent    drug    designed    researcher    protein    induce    collaborations    group    tumour    carry    maturity    academic    dr    synergistic    national    biochemistry    cell    mode    tabrizi    simultaneously    erxleben    intracellular    strength    death    inhibition    proteins    carrier    months    synthetic    scientific    strategically    techniques    mentoring    reductase    university    metal    awarded    industrial    area    galway    manner    anticancer    complexes    receiving    selective    training    biological    progression    vitro    performed    synthesis    ireland    iranian    drugs    cancer    24    proposes    thioredoxin    transferable    structure    understand    release    leila    chemistry    inhibitor    professional    postdoctoral    biomedical    deepen    medicinal    binding    enter    candidates    types    gold    background    branches    relationships    nui   

Project "TSPO METALLODRUGS" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

Dr. Leila Tabrizi, an Iranian national, is making an application to this programme to carry out a 24 months project in the area of medicinal chemistry in the group of Dr. A. Erxleben at the National University of Ireland, Galway. The objective of this proposal is the synthesis of novel gold anticancer drugs that simultaneously target two mitochondrial proteins that are associated with cancer progression. Gold(III) complexes will be designed that recognize the translocator protein which is overexpressed in various tumour types and that release the metal upon intracellular reduction to gold(I), a known inhibitor of thioredoxin reductase. Binding of the carrier ligand to the translocator protein and inhibition of thioredoxin reductase will induce cell death pathways in a synergistic manner, thus leading to highly effective and selective anticancer action. Detailed in vitro biological studies will be performed to evaluate the potential of the new anticancer drug candidates, to establish structure-activity relationships and to fully understand their mode of action. The researcher has already an excellent background in coordination chemistry and this project will allow her to deepen and expand her skills in synthetic chemistry, to enter into the biological field by receiving relevant training in cell and biological techniques and to establish important academic and industrial collaborations. The researcher who has recently been awarded a Government of Ireland Postdoctoral Fellowship proposes to carry out further research training at NUI Galway which is strategically developing strength in Biomedical Research and Cancer, one of the most important and challenging branches of Chemistry/Biochemistry in Europe. NUI Galway will also provide training in transferable skills and mentoring to the researcher. Both the scientific and personal training will contribute to her personal development and will allow her to reach professional maturity as an independent researcher.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TSPO METALLODRUGS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TSPO METALLODRUGS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

GW (2019)

Analysing the heavy element factories of the Universe : photometric and spectroscopic sample study of kilonovae

Read More  

RegulatioNFkB (2019)

Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches

Read More