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Novel, highly effective and selective anticancer metallodrugs

Total Cost €


EC-Contrib. €






 TSPO METALLODRUGS project word cloud

Explore the words cloud of the TSPO METALLODRUGS project. It provides you a very rough idea of what is the project "TSPO METALLODRUGS" about.

leila    recognize    translocator    protein    overexpressed    national    strength    tumour    vitro    collaborations    binding    intracellular    ireland    enter    government    synthesis    industrial    skills    reductase    tabrizi    metal    personal    galway    thioredoxin    action    medicinal    understand    proteins    drugs    types    fellowship    iranian    university    carry    nui    designed    mitochondrial    academic    biochemistry    excellent    expand    structure    carrier    mentoring    branches    dr    awarded    anticancer    release    group    complexes    strategically    inhibitor    proposes    death    deepen    gold    transferable    synergistic    manner    24    ligand    synthetic    training    selective    techniques    performed    inhibition    maturity    induce    chemistry    background    professional    researcher    progression    candidates    scientific    receiving    erxleben    independent    drug    relationships    months    area    biomedical    biological    cancer    postdoctoral    mode    cell    simultaneously   

Project "TSPO METALLODRUGS" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2020-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00


 Project objective

Dr. Leila Tabrizi, an Iranian national, is making an application to this programme to carry out a 24 months project in the area of medicinal chemistry in the group of Dr. A. Erxleben at the National University of Ireland, Galway. The objective of this proposal is the synthesis of novel gold anticancer drugs that simultaneously target two mitochondrial proteins that are associated with cancer progression. Gold(III) complexes will be designed that recognize the translocator protein which is overexpressed in various tumour types and that release the metal upon intracellular reduction to gold(I), a known inhibitor of thioredoxin reductase. Binding of the carrier ligand to the translocator protein and inhibition of thioredoxin reductase will induce cell death pathways in a synergistic manner, thus leading to highly effective and selective anticancer action. Detailed in vitro biological studies will be performed to evaluate the potential of the new anticancer drug candidates, to establish structure-activity relationships and to fully understand their mode of action. The researcher has already an excellent background in coordination chemistry and this project will allow her to deepen and expand her skills in synthetic chemistry, to enter into the biological field by receiving relevant training in cell and biological techniques and to establish important academic and industrial collaborations. The researcher who has recently been awarded a Government of Ireland Postdoctoral Fellowship proposes to carry out further research training at NUI Galway which is strategically developing strength in Biomedical Research and Cancer, one of the most important and challenging branches of Chemistry/Biochemistry in Europe. NUI Galway will also provide training in transferable skills and mentoring to the researcher. Both the scientific and personal training will contribute to her personal development and will allow her to reach professional maturity as an independent researcher.

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The information about "TSPO METALLODRUGS" are provided by the European Opendata Portal: CORDIS opendata.

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