Explore the words cloud of the EpiMethFly project. It provides you a very rough idea of what is the project "EpiMethFly" about.
The following table provides information about the project.
UNIVERSITA DEGLI STUDI DI TRENTO
|Coordinator Country||Italy [IT]|
|Total cost||180˙277 €|
|EC max contribution||180˙277 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-09-19 to 2020-04-18|
Take a look of project's partnership.
|1||UNIVERSITA DEGLI STUDI DI TRENTO||IT (TRENTO)||coordinator||180˙277.00|
The identification of reversible m6A RNA modification strongly points towards the existence of a novel level of complexity of gene expression regulation. Recent studies have suggested that m6A might be involved in several biological processes and that dysregulation of this modification may contributes to neuro-developmental abnormalities and cancer. The aim of the described research is to clarify the role of m6A RNA modification in the nervous system in physiological conditions -during brain development - and to discover its contribution to pathological conditions - Glioblastoma. To achieve this goal I propose to use Drosophila melanogaster to study : Aim 1 the impact of perturbing different members of the m6A machinery on brain morphology, progenitors differentiation and neuronal axon growth and guidance; Aim2 the impact of modulating the levels of m6A RNA modification in a Glioblastoma model and study the effect of this perturbation on tumor growth and progression. The results obtained will be of fundamental importance for the development of the field of epitranscriptomics by shedding light on the biological outcome of m6A modification in-vivo. In particular, Drosophila might become an efficient model to screen for novel members of the m6A machinery and to clarify how m6A is read and translated into a biological response. Finally, the data obtained by the analysis of the Glioblastoma model, will strongly contribute to the understanding of the link between RNA methylation and tumor development and aggressiveness.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPIMETHFLY" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "EPIMETHFLY" are provided by the European Opendata Portal: CORDIS opendata.
Gender, Infrastructure and the Production of Domesticity in the (Post)Communist CityRead More
Josephson maser and heat transport in dissipative open quantum systemsRead More
Neural stochasticity and criticality in memory replayRead More