Explore the words cloud of the PROM project. It provides you a very rough idea of what is the project "PROM" about.
The following table provides information about the project.
UNIVERSITY OF LEEDS
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-07-01 to 2019-06-30|
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PreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases. Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to multiple factor. Evidences linked environmental toxicant exposure and infection with a decreased fertility and an increase PTB rate. Studies of these topics suffered for limits of in vitro cell culture (e.g. absence of extracellular environment, dilution) and anatomical, physiological, endocrine differences between human and animal models.
Long term goal of this project is to create Organ-on-a-Chip (OoC) models of the human endometrium and the human foetal membranes to assess the effects of environmental insults, such as infection or inflammation, to exacerbate preterm birth. An overarching goal is to utilize these OoC models to identify personalized therapy to improve and preserve fertility.
This project aims to 1.Implement an OoC model to replicate the physiology of the human endometrium and the development of the foetal membranes during pregnancy. This will be achieved by adding human amniotic epithelial, chorionic trophoblasts and maternal macrophages in the existing OoC. 2.Define the individual contributions of each cell type in the endometrium to paracrine signalling events that lead to PTB. A sub-micrometric polymeric, porous membrane will be integrated in the chip, will allow chemical communication between the cellular compartments of the OoC, will support formation of cell layers and will favour close proximity between the different cell types. 3.Monitor metabolic activity and identify PTB biomarkers. Changes in metabolic activity of each cell types, biomarkers of infection and inflammation in response to unknown stressors (e.g. bacteria/ toxins/chemotherapy) will be identified by downstream collection of effluents and direct single cell sensing.
|year||authors and title||journal||last update|
Jacquelyn A. Brown, Virginia Pensabene, Dmitry A. Markov, Vanessa Allwardt, M. Diana Neely, Mingjian Shi, Clayton M. Britt, Orlando S. Hoilett, Qing Yang, Bryson M. Brewer, Philip C. Samson, Lisa J. McCawley, James M. May, Donna J. Webb, Deyu Li, Aaron B. Bowman, Ronald S. Reiserer, John P. Wikswo
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
published pages: 54124, ISSN: 1932-1058, DOI: 10.1063/1.4934713
Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1
|Biomedical Microdevices 19/3||2020-03-23|
Kaylon L. Bruner-Tran, Juan Gnecco, Tianbing Ding, Dana R. Glore, Virginia Pensabene, Kevin G. Osteen
Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models
published pages: 59-71, ISSN: 0890-6238, DOI: 10.1016/j.reprotox.2016.07.007
|Reproductive Toxicology 68||2020-03-23|
M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen, Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A.
Organs-on-Chips as Bridges for Predictive Toxicology
published pages: 97-102, ISSN: 2332-1512, DOI: 10.1089/aivt.2016.0003
|Applied In Vitro Toxicology 2/2||2020-03-23|
Juan S. Gnecco, Virginia Pensabene, David J. Li, Tianbing Ding, Elliot E. Hui, Kaylon L. Bruner-Tran, Kevin G. Osteen
Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium
published pages: 1758-1769, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1797-5
|Annals of Biomedical Engineering 45/7||2020-03-23|
Vanessa Mancini, Virginia Pensabene
Organs-On-Chip Models of the Female Reproductive System
published pages: 103, ISSN: 2306-5354, DOI: 10.3390/bioengineering6040103
Espinilla Aguilar, C
The metabolic and developmental impact of a novel microfluidic device for mammalian embryo culture.
published pages: 14, ISSN: , DOI:
|Fertility 2019 Abstract Book Annual meetign proceedings||2020-03-23|
McKeegan, PJ https://orcid.org/0000-0002-5318-2317
Pensabene, V https://orcid.org/0000-0002-3352-8202
2019 | Scientific Abstracts
published pages: 62A-390A, ISSN: 1933-7191, DOI: 10.1177/1933719119834079
|Reproductive Sciences 26/1_suppl||2020-03-23|
The use of a novel microfluidic culture device and predictive metabolic profiling as a means to improve murine embryo developmental competence in vitro
published pages: 127, ISSN: , DOI:
|AETE Proceedings 2018. 34th Scientific Meeting of the Association of Embryo Technology in Europe Annual conference proceedings||2020-03-23|
Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen, David M. Aronoff
Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research
published pages: 6115-6124, ISSN: 1381-6128, DOI: 10.2174/1381612823666170825142649
|Current Pharmaceutical Design 23/40||2020-03-23|
Pensabene, V https://orcid.org/0000-0002-3352-8202
On-chip mouse embryo culture: Evaluation of effects of uterine cells-conditioned media on embryo development and gene expression
published pages: 18, ISSN: , DOI:
|Fertility 2019 Abstract Book annual meeting proceedings||2020-03-23|
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