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PROM

Pregnancy and Reproduction Organ-on-a-chip Models

Total Cost €

0

EC-Contrib. €

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Partnership

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 Outcomes and results

 PROM project word cloud

Explore the words cloud of the PROM project. It provides you a very rough idea of what is the project "PROM" about.

proximity    rate    diseases    trophoblasts    unknown    born    uk    utilize    foetal    neurodevelopmental    chemical    weeks    organ    signalling    attributable    replicate    preterm    infection    contributions    pregnancy    culture    physiology    inflammation    effluents    therapy    deficits    models    close    insults    membrane    occurs    babies    absence    paracrine    biomarkers    sensing    micrometric    chemotherapy    endometrium    toxicant    endocrine    maternal    cellular    model    layers    chorionic    1    syndrome    epithelial    environmental    animal    die    membranes    sub    adding    ooc    compartments    extracellular    personalized    differences    physiological    ptb    chip    metabolic    communication    types    events    400    cell    decreased    premature    exacerbate    amniotic    exposure    linked    vitro    collection    monitor    preserve    suffered    single    porous    human    toxins    direct    individual    rupture    downstream    environment    overarching    gestation    stressors    create    anatomical    37    bacteria    dilution    macrophages    limits    evidences    polymeric    multiple    chronic    fertility    prom    prematurely    birth    risks   

Project "PROM" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://engineering.leeds.ac.uk/staff/870/Dr_Virginia_Pensabene
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

PreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases. Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to multiple factor. Evidences linked environmental toxicant exposure and infection with a decreased fertility and an increase PTB rate. Studies of these topics suffered for limits of in vitro cell culture (e.g. absence of extracellular environment, dilution) and anatomical, physiological, endocrine differences between human and animal models.

Long term goal of this project is to create Organ-on-a-Chip (OoC) models of the human endometrium and the human foetal membranes to assess the effects of environmental insults, such as infection or inflammation, to exacerbate preterm birth. An overarching goal is to utilize these OoC models to identify personalized therapy to improve and preserve fertility.

This project aims to 1.Implement an OoC model to replicate the physiology of the human endometrium and the development of the foetal membranes during pregnancy. This will be achieved by adding human amniotic epithelial, chorionic trophoblasts and maternal macrophages in the existing OoC. 2.Define the individual contributions of each cell type in the endometrium to paracrine signalling events that lead to PTB. A sub-micrometric polymeric, porous membrane will be integrated in the chip, will allow chemical communication between the cellular compartments of the OoC, will support formation of cell layers and will favour close proximity between the different cell types. 3.Monitor metabolic activity and identify PTB biomarkers. Changes in metabolic activity of each cell types, biomarkers of infection and inflammation in response to unknown stressors (e.g. bacteria/ toxins/chemotherapy) will be identified by downstream collection of effluents and direct single cell sensing.

 Publications

year authors and title journal last update
List of publications.
2015 Jacquelyn A. Brown, Virginia Pensabene, Dmitry A. Markov, Vanessa Allwardt, M. Diana Neely, Mingjian Shi, Clayton M. Britt, Orlando S. Hoilett, Qing Yang, Bryson M. Brewer, Philip C. Samson, Lisa J. McCawley, James M. May, Donna J. Webb, Deyu Li, Aaron B. Bowman, Ronald S. Reiserer, John P. Wikswo
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
published pages: 54124, ISSN: 1932-1058, DOI: 10.1063/1.4934713 		Biomicrofluidics 9/5 2020-03-23
2017 Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1 		Biomedical Microdevices 19/3 2020-03-23
2017 Kaylon L. Bruner-Tran, Juan Gnecco, Tianbing Ding, Dana R. Glore, Virginia Pensabene, Kevin G. Osteen
Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models
published pages: 59-71, ISSN: 0890-6238, DOI: 10.1016/j.reprotox.2016.07.007 		Reproductive Toxicology 68 2020-03-23
2016 M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen, Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A.
Organs-on-Chips as Bridges for Predictive Toxicology
published pages: 97-102, ISSN: 2332-1512, DOI: 10.1089/aivt.2016.0003 		Applied In Vitro Toxicology 2/2 2020-03-23
2017 Juan S. Gnecco, Virginia Pensabene, David J. Li, Tianbing Ding, Elliot E. Hui, Kaylon L. Bruner-Tran, Kevin G. Osteen
Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium
published pages: 1758-1769, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1797-5 		Annals of Biomedical Engineering 45/7 2020-03-23
2019 Vanessa Mancini, Virginia Pensabene
Organs-On-Chip Models of the Female Reproductive System
published pages: 103, ISSN: 2306-5354, DOI: 10.3390/bioengineering6040103 		Bioengineering 6/4 2020-03-23
2019 McKeegan, P Colucci, F Espinilla Aguilar, C Pensabene, V Picton, H
The metabolic and developmental impact of a novel microfluidic device for mammalian embryo culture.
published pages: 14, ISSN: , DOI: 		Fertility 2019 Abstract Book Annual meetign proceedings 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ https://orcid.org/0000-0002-5318-2317 Huntriss, JD Picton, HM Pensabene, V https://orcid.org/0000-0002-3352-8202
2019 | Scientific Abstracts
published pages: 62A-390A, ISSN: 1933-7191, DOI: 10.1177/1933719119834079 		Reproductive Sciences 26/1_suppl 2020-03-23
2019 McKeegan, PJ Colucci, F Picton, HM Pensabene, V
The use of a novel microfluidic culture device and predictive metabolic profiling as a means to improve murine embryo developmental competence in vitro
published pages: 127, ISSN: , DOI: 		AETE Proceedings 2018. 34th Scientific Meeting of the Association of Embryo Technology in Europe Annual conference proceedings 2020-03-23
2018 Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen, David M. Aronoff
Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research
published pages: 6115-6124, ISSN: 1381-6128, DOI: 10.2174/1381612823666170825142649 		Current Pharmaceutical Design 23/40 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ Huntriss, JD Picton, HM Pensabene, V https://orcid.org/0000-0002-3352-8202
On-chip mouse embryo culture: Evaluation of effects of uterine cells-conditioned media on embryo development and gene expression
published pages: 18, ISSN: , DOI: 		Fertility 2019 Abstract Book annual meeting proceedings 2020-03-23

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