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PROM

Pregnancy and Reproduction Organ-on-a-chip Models

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 PROM project word cloud

Explore the words cloud of the PROM project. It provides you a very rough idea of what is the project "PROM" about.

human    membrane    macrophages    collection    cellular    adding    monitor    animal    syndrome    organ    preterm    cell    therapy    diseases    porous    pregnancy    contributions    multiple    overarching    metabolic    unknown    gestation    evidences    physiological    micrometric    communication    maternal    downstream    1    neurodevelopmental    stressors    membranes    born    chemotherapy    sensing    events    anatomical    models    replicate    biomarkers    attributable    preserve    rupture    400    prom    toxicant    insults    utilize    extracellular    polymeric    inflammation    epithelial    signalling    absence    direct    limits    environmental    dilution    differences    bacteria    endocrine    fertility    layers    rate    linked    personalized    infection    decreased    37    suffered    compartments    trophoblasts    weeks    environment    risks    vitro    sub    endometrium    birth    individual    exposure    effluents    uk    paracrine    chip    proximity    chemical    physiology    model    amniotic    prematurely    occurs    ptb    single    babies    deficits    close    chorionic    chronic    die    ooc    premature    foetal    types    exacerbate    toxins    create    culture   

Project "PROM" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://engineering.leeds.ac.uk/staff/870/Dr_Virginia_Pensabene
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00

Map

 Project objective

PreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases. Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to multiple factor. Evidences linked environmental toxicant exposure and infection with a decreased fertility and an increase PTB rate. Studies of these topics suffered for limits of in vitro cell culture (e.g. absence of extracellular environment, dilution) and anatomical, physiological, endocrine differences between human and animal models.

Long term goal of this project is to create Organ-on-a-Chip (OoC) models of the human endometrium and the human foetal membranes to assess the effects of environmental insults, such as infection or inflammation, to exacerbate preterm birth. An overarching goal is to utilize these OoC models to identify personalized therapy to improve and preserve fertility.

This project aims to 1.Implement an OoC model to replicate the physiology of the human endometrium and the development of the foetal membranes during pregnancy. This will be achieved by adding human amniotic epithelial, chorionic trophoblasts and maternal macrophages in the existing OoC. 2.Define the individual contributions of each cell type in the endometrium to paracrine signalling events that lead to PTB. A sub-micrometric polymeric, porous membrane will be integrated in the chip, will allow chemical communication between the cellular compartments of the OoC, will support formation of cell layers and will favour close proximity between the different cell types. 3.Monitor metabolic activity and identify PTB biomarkers. Changes in metabolic activity of each cell types, biomarkers of infection and inflammation in response to unknown stressors (e.g. bacteria/ toxins/chemotherapy) will be identified by downstream collection of effluents and direct single cell sensing.

 Publications

year authors and title journal last update
List of publications.
2015 Jacquelyn A. Brown, Virginia Pensabene, Dmitry A. Markov, Vanessa Allwardt, M. Diana Neely, Mingjian Shi, Clayton M. Britt, Orlando S. Hoilett, Qing Yang, Bryson M. Brewer, Philip C. Samson, Lisa J. McCawley, James M. May, Donna J. Webb, Deyu Li, Aaron B. Bowman, Ronald S. Reiserer, John P. Wikswo
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
published pages: 54124, ISSN: 1932-1058, DOI: 10.1063/1.4934713 		Biomicrofluidics 9/5 2020-03-23
2017 Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1 		Biomedical Microdevices 19/3 2020-03-23
2017 Kaylon L. Bruner-Tran, Juan Gnecco, Tianbing Ding, Dana R. Glore, Virginia Pensabene, Kevin G. Osteen
Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models
published pages: 59-71, ISSN: 0890-6238, DOI: 10.1016/j.reprotox.2016.07.007 		Reproductive Toxicology 68 2020-03-23
2016 M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen, Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A.
Organs-on-Chips as Bridges for Predictive Toxicology
published pages: 97-102, ISSN: 2332-1512, DOI: 10.1089/aivt.2016.0003 		Applied In Vitro Toxicology 2/2 2020-03-23
2017 Juan S. Gnecco, Virginia Pensabene, David J. Li, Tianbing Ding, Elliot E. Hui, Kaylon L. Bruner-Tran, Kevin G. Osteen
Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium
published pages: 1758-1769, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1797-5 		Annals of Biomedical Engineering 45/7 2020-03-23
2019 Vanessa Mancini, Virginia Pensabene
Organs-On-Chip Models of the Female Reproductive System
published pages: 103, ISSN: 2306-5354, DOI: 10.3390/bioengineering6040103 		Bioengineering 6/4 2020-03-23
2019 McKeegan, P Colucci, F Espinilla Aguilar, C Pensabene, V Picton, H
The metabolic and developmental impact of a novel microfluidic device for mammalian embryo culture.
published pages: 14, ISSN: , DOI: 		Fertility 2019 Abstract Book Annual meetign proceedings 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ https://orcid.org/0000-0002-5318-2317 Huntriss, JD Picton, HM Pensabene, V https://orcid.org/0000-0002-3352-8202
2019 | Scientific Abstracts
published pages: 62A-390A, ISSN: 1933-7191, DOI: 10.1177/1933719119834079 		Reproductive Sciences 26/1_suppl 2020-03-23
2019 McKeegan, PJ Colucci, F Picton, HM Pensabene, V
The use of a novel microfluidic culture device and predictive metabolic profiling as a means to improve murine embryo developmental competence in vitro
published pages: 127, ISSN: , DOI: 		AETE Proceedings 2018. 34th Scientific Meeting of the Association of Embryo Technology in Europe Annual conference proceedings 2020-03-23
2018 Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen, David M. Aronoff
Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research
published pages: 6115-6124, ISSN: 1381-6128, DOI: 10.2174/1381612823666170825142649 		Current Pharmaceutical Design 23/40 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ Huntriss, JD Picton, HM Pensabene, V https://orcid.org/0000-0002-3352-8202
On-chip mouse embryo culture: Evaluation of effects of uterine cells-conditioned media on embryo development and gene expression
published pages: 18, ISSN: , DOI: 		Fertility 2019 Abstract Book annual meeting proceedings 2020-03-23

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