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Pregnancy and Reproduction Organ-on-a-chip Models

Total Cost €


EC-Contrib. €






 PROM project word cloud

Explore the words cloud of the PROM project. It provides you a very rough idea of what is the project "PROM" about.

37    toxicant    die    compartments    human    paracrine    birth    deficits    chemical    400    types    effluents    bacteria    model    overarching    chip    insults    preserve    gestation    stressors    individual    maternal    rate    absence    born    sensing    signalling    toxins    create    environmental    unknown    vitro    culture    porous    premature    syndrome    exposure    macrophages    infection    decreased    animal    close    membrane    linked    rupture    sub    physiology    neurodevelopmental    biomarkers    weeks    direct    suffered    physiological    adding    ooc    layers    trophoblasts    polymeric    cell    downstream    chemotherapy    communication    epithelial    therapy    multiple    anatomical    exacerbate    contributions    proximity    preterm    diseases    fertility    single       dilution    monitor    chorionic    endometrium    personalized    metabolic    babies    utilize    prematurely    cellular    environment    amniotic    uk    collection    ptb    events    endocrine    micrometric    replicate    risks    attributable    foetal    extracellular    pregnancy    limits    differences    chronic    inflammation    evidences    organ    membranes    occurs    prom    models   

Project "PROM" data sheet

The following table provides information about the project.


Organization address
city: LEEDS
postcode: LS2 9JT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 195˙454.00


 Project objective

PreTerm Birth (PTB) occurs before 37 weeks of gestation. Of 60,000 babies born prematurely every year in UK, ~1,400 die. Premature babies show increased risks of long term neurodevelopmental deficits and chronic diseases. Preterm Rupture of the foetal Membranes (PROM) is a syndrome attributable to multiple factor. Evidences linked environmental toxicant exposure and infection with a decreased fertility and an increase PTB rate. Studies of these topics suffered for limits of in vitro cell culture (e.g. absence of extracellular environment, dilution) and anatomical, physiological, endocrine differences between human and animal models.

Long term goal of this project is to create Organ-on-a-Chip (OoC) models of the human endometrium and the human foetal membranes to assess the effects of environmental insults, such as infection or inflammation, to exacerbate preterm birth. An overarching goal is to utilize these OoC models to identify personalized therapy to improve and preserve fertility.

This project aims to 1.Implement an OoC model to replicate the physiology of the human endometrium and the development of the foetal membranes during pregnancy. This will be achieved by adding human amniotic epithelial, chorionic trophoblasts and maternal macrophages in the existing OoC. 2.Define the individual contributions of each cell type in the endometrium to paracrine signalling events that lead to PTB. A sub-micrometric polymeric, porous membrane will be integrated in the chip, will allow chemical communication between the cellular compartments of the OoC, will support formation of cell layers and will favour close proximity between the different cell types. 3.Monitor metabolic activity and identify PTB biomarkers. Changes in metabolic activity of each cell types, biomarkers of infection and inflammation in response to unknown stressors (e.g. bacteria/ toxins/chemotherapy) will be identified by downstream collection of effluents and direct single cell sensing.


year authors and title journal last update
List of publications.
2015 Jacquelyn A. Brown, Virginia Pensabene, Dmitry A. Markov, Vanessa Allwardt, M. Diana Neely, Mingjian Shi, Clayton M. Britt, Orlando S. Hoilett, Qing Yang, Bryson M. Brewer, Philip C. Samson, Lisa J. McCawley, James M. May, Donna J. Webb, Deyu Li, Aaron B. Bowman, Ronald S. Reiserer, John P. Wikswo
Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
published pages: 54124, ISSN: 1932-1058, DOI: 10.1063/1.4934713
Biomicrofluidics 9/5 2020-03-23
2017 Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli
On the injectability of free-standing magnetic nanofilms
published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1
Biomedical Microdevices 19/3 2020-03-23
2017 Kaylon L. Bruner-Tran, Juan Gnecco, Tianbing Ding, Dana R. Glore, Virginia Pensabene, Kevin G. Osteen
Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models
published pages: 59-71, ISSN: 0890-6238, DOI: 10.1016/j.reprotox.2016.07.007
Reproductive Toxicology 68 2020-03-23
2016 M. Shane Hutson, Peter G. Alexander, Vanessa Allwardt, David M. Aronoff, Kaylon L. Bruner-Tran, David E. Cliffel, Jeffrey M. Davidson, Albert Gough, Dmitry A. Markov, Lisa J. McCawley, Jennifer R. McKenzie, John A. McLean, Kevin G. Osteen, Virginia Pensabene, Philip C. Samson, Nina K. Senutovitch, Stacy D. Sherrod, Matthew S. Shotwell, D. Lansing Taylor, Lauren M. Tetz, Rocky S. Tuan, Lawrence A.
Organs-on-Chips as Bridges for Predictive Toxicology
published pages: 97-102, ISSN: 2332-1512, DOI: 10.1089/aivt.2016.0003
Applied In Vitro Toxicology 2/2 2020-03-23
2017 Juan S. Gnecco, Virginia Pensabene, David J. Li, Tianbing Ding, Elliot E. Hui, Kaylon L. Bruner-Tran, Kevin G. Osteen
Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium
published pages: 1758-1769, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1797-5
Annals of Biomedical Engineering 45/7 2020-03-23
2019 Vanessa Mancini, Virginia Pensabene
Organs-On-Chip Models of the Female Reproductive System
published pages: 103, ISSN: 2306-5354, DOI: 10.3390/bioengineering6040103
Bioengineering 6/4 2020-03-23
2019 McKeegan, P Colucci, F Espinilla Aguilar, C Pensabene, V Picton, H
The metabolic and developmental impact of a novel microfluidic device for mammalian embryo culture.
published pages: 14, ISSN: , DOI:
Fertility 2019 Abstract Book Annual meetign proceedings 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ Huntriss, JD Picton, HM Pensabene, V
2019 | Scientific Abstracts
published pages: 62A-390A, ISSN: 1933-7191, DOI: 10.1177/1933719119834079
Reproductive Sciences 26/1_suppl 2020-03-23
2019 McKeegan, PJ Colucci, F Picton, HM Pensabene, V
The use of a novel microfluidic culture device and predictive metabolic profiling as a means to improve murine embryo developmental competence in vitro
published pages: 127, ISSN: , DOI:
AETE Proceedings 2018. 34th Scientific Meeting of the Association of Embryo Technology in Europe Annual conference proceedings 2020-03-23
2018 Juan S. Gnecco, Anjali P. Anders, David Cliffel, Virginia Pensabene, Lisa M. Rogers, Kevin Osteen, David M. Aronoff
Instrumenting a Fetal Membrane on a Chip as Emerging Technology for Preterm Birth Research
published pages: 6115-6124, ISSN: 1381-6128, DOI: 10.2174/1381612823666170825142649
Current Pharmaceutical Design 23/40 2020-03-23
2019 Mancini, V Lu, J Colucci, F McKeegan, PJ Huntriss, JD Picton, HM Pensabene, V
On-chip mouse embryo culture: Evaluation of effects of uterine cells-conditioned media on embryo development and gene expression
published pages: 18, ISSN: , DOI:
Fertility 2019 Abstract Book annual meeting proceedings 2020-03-23

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