Opendata, web and dolomites

TOLERANCE FOOTPRINT SIGNED

Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T CellRepertoire

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TOLERANCE FOOTPRINT project word cloud

Explore the words cloud of the TOLERANCE FOOTPRINT project. It provides you a very rough idea of what is the project "TOLERANCE FOOTPRINT" about.

censored    paucity    visualizing    fundamental    contribution    autoreactive    benign    specify    determined    fundamentally    subject    immunology    fates    diversion    antigen    biology    individual    reveal    breakthroughs    tolerance    unravelling    eliminated    thymus    diverse    encounter    either    receptors    mechanisms    repertoire    multiple    endogenous    sub    tcr    promise    mode    determinants    potentially    specifying    tcrs    uncensored    diverted    technological    poorly    treg    intrinsic    obstacle    dangerous    clonal    re    regarding    minute    paradoxically    therapeutic    cohorts    remarkably    modes    elucidates    sequencing    vertebrate    versus    programmed    relative    repertoires    autoantigen    deletion    operates    extrinsic    generates    deleted    cells    causes    tackle    immune    ensue    diverts    opposing    experimental    questions    characterizing    self    shared    expertise    absence    diseases    autoimmune    autoimmunity    differentiate    disease    opportunity    cell    holes    implications    classify    sclerosis    diabetes    specificity    entities    harnessing    regulatory   

Project "TOLERANCE FOOTPRINT" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙414˙500 €
 EC max contribution 2˙414˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙414˙500.00

Map

 Project objective

Self-tolerance is a key feature of the immune system; its failure causes autoimmune diseases such as Multiple Sclerosis or Type-1-Diabetes. Remarkably, T cell tolerance operates via two fundamentally different mechanisms: potentially dangerous cells are either eliminated (clonal deletion) or re-programmed to differentiate into regulatory T (Treg) cells (clonal diversion). Paradoxically, both tolerance modes can ensue from self-antigen-encounter in the thymus, and the parameters specifying these opposing cell-fates remain poorly understood. Moreover, the relative contribution of clonal deletion versus clonal diversion to tolerance at the level of diverse immune cell repertoires has not been determined. In particular, the paucity of antigen-specific cells is a major experimental obstacle to unravelling to what extent cells with shared autoreactive specificity, yet different T cell receptors (TCRs), are subject to either mode of tolerance. Breakthroughs in visualizing minute cohorts of antigen-specific cells, characterizing the TCRs on individual cells and large-scale TCR sequencing now provide a unique opportunity to tackle these challenging questions. Based upon my expertise in thymus biology and T cell selection, I will exploit these technological advances to reveal where and how tolerance either generates ‘holes’ in the repertoire or diverts cells into a ‘benign’ sub-repertoire. The main objectives are (i) to identify and classify deleted or diverted TCR-entities through comparing ‘uncensored’ and ‘censored’ repertoires in the absence or presence of a disease-relevant autoantigen and (ii) to identify TCR intrinsic features as well as T cell extrinsic determinants that specify clonal deletion versus clonal diversion. The proposed research elucidates a fundamental aspect of vertebrate immunology, but also has major implications regarding the therapeutic promise of harnessing endogenous, antigen-specific Treg cells in autoimmunity.

 Publications

year authors and title journal last update
List of publications.
2019 Ludger Klein, Ellen A. Robey, Chyi-Song Hsieh
Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation
published pages: 7-18, ISSN: 1474-1733, DOI: 10.1038/s41577-018-0083-6
Nature Reviews Immunology 19/1 2019-06-07

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TOLERANCE FOOTPRINT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TOLERANCE FOOTPRINT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

CARBYNE (2020)

New carbon reactivity rules for molecular editing

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More