Opendata, web and dolomites

TOLERANCE FOOTPRINT SIGNED

Clonal Deletion versus Clonal Diversion: Footprints of Self-Tolerance in the T CellRepertoire

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TOLERANCE FOOTPRINT project word cloud

Explore the words cloud of the TOLERANCE FOOTPRINT project. It provides you a very rough idea of what is the project "TOLERANCE FOOTPRINT" about.

contribution    intrinsic    diverse    mechanisms    holes    thymus    differentiate    specifying    diseases    mode    diverted    fundamentally    tcr    elucidates    expertise    immune    biology    deleted    programmed    entities    regulatory    fundamental    clonal    generates    visualizing    tcrs    minute    either    diverts    eliminated    individual    self    autoimmune    causes    sub    relative    cohorts    potentially    vertebrate    remarkably    censored    tackle    antigen    autoimmunity    cells    immunology    absence    implications    encounter    subject    breakthroughs    repertoires    autoantigen    versus    benign    harnessing    dangerous    paradoxically    technological    sequencing    classify    autoreactive    endogenous    extrinsic    disease    regarding    uncensored    obstacle    questions    ensue    diabetes    characterizing    reveal    experimental    modes    opportunity    unravelling    repertoire    tolerance    deletion    treg    determinants    re    therapeutic    receptors    specify    specificity    determined    multiple    shared    sclerosis    promise    fates    poorly    paucity    operates    diversion    cell    opposing   

Project "TOLERANCE FOOTPRINT" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙414˙500 €
 EC max contribution 2˙414˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 2˙414˙500.00

Map

 Project objective

Self-tolerance is a key feature of the immune system; its failure causes autoimmune diseases such as Multiple Sclerosis or Type-1-Diabetes. Remarkably, T cell tolerance operates via two fundamentally different mechanisms: potentially dangerous cells are either eliminated (clonal deletion) or re-programmed to differentiate into regulatory T (Treg) cells (clonal diversion). Paradoxically, both tolerance modes can ensue from self-antigen-encounter in the thymus, and the parameters specifying these opposing cell-fates remain poorly understood. Moreover, the relative contribution of clonal deletion versus clonal diversion to tolerance at the level of diverse immune cell repertoires has not been determined. In particular, the paucity of antigen-specific cells is a major experimental obstacle to unravelling to what extent cells with shared autoreactive specificity, yet different T cell receptors (TCRs), are subject to either mode of tolerance. Breakthroughs in visualizing minute cohorts of antigen-specific cells, characterizing the TCRs on individual cells and large-scale TCR sequencing now provide a unique opportunity to tackle these challenging questions. Based upon my expertise in thymus biology and T cell selection, I will exploit these technological advances to reveal where and how tolerance either generates ‘holes’ in the repertoire or diverts cells into a ‘benign’ sub-repertoire. The main objectives are (i) to identify and classify deleted or diverted TCR-entities through comparing ‘uncensored’ and ‘censored’ repertoires in the absence or presence of a disease-relevant autoantigen and (ii) to identify TCR intrinsic features as well as T cell extrinsic determinants that specify clonal deletion versus clonal diversion. The proposed research elucidates a fundamental aspect of vertebrate immunology, but also has major implications regarding the therapeutic promise of harnessing endogenous, antigen-specific Treg cells in autoimmunity.

 Publications

year authors and title journal last update
List of publications.
2019 Ludger Klein, Ellen A. Robey, Chyi-Song Hsieh
Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation
published pages: 7-18, ISSN: 1474-1733, DOI: 10.1038/s41577-018-0083-6
Nature Reviews Immunology 19/1 2019-06-07

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TOLERANCE FOOTPRINT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TOLERANCE FOOTPRINT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More