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MiRCHOL SIGNED

Mechanistic and therapeutic implications of microRNA deregulation for drug resistance in bile duct cancer

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MiRCHOL project word cloud

Explore the words cloud of the MiRCHOL project. It provides you a very rough idea of what is the project "MiRCHOL" about.

urgently    alone    researcher    involvement    treatment    achievement    orchestrating    heterogeneity    dismal    mortality    scientific    patients    complicating    linking    rate    skills    transcriptomes    expand    multiple    ing    70    genes    yield    characterization    expert    chemoresistance    world    integrate    hepatobiliary    emphasized    mirs       genomic    efficacy    crispr    unresectable    hence    options    insights    vast    andersen    regulate    last    diagnosis    me    mir    survival    doubled    editing    transferable    modulate    drug    completion    data    pathogenesis    liver    deregulation    society    cancer    tumor    expertise    disease    besides    plus    consequence    stage    micrornas    independent    cancers    unclear    chemoresistant    resistance    therapy    37    genome    patient    gt    pattern    medicine    supervise    instability    outcome    molecular    matched    clinical    deregulated    metastasis    successful    cholangiocarcinoma    dr    incidence    myself    progression    limited    reflecting    translational    cca    expression   

Project "MiRCHOL" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2020-07-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 200˙194.00

Map

 Project objective

Cholangiocarcinoma (CCA) is a dismal type of liver cancer which incidence has more than doubled the last 20 years and mortality rate in Europe alone increased 37%, reflecting the limited treatment options. In >70% of patients CCA is unresectable due to advanced stage of disease at diagnosis, resulting in a 5% 5-year survival rate. CCA is characterized by molecular and clinical heterogeneity, complicating therapy and assessment of drug efficacy. Tumor heterogeneity is emphasized in limited response of therapy (drug resistance) and besides genomic instability a likely consequence of deregulated pathways under control of microRNAs (miRs). Each miR can regulate multiple genes/pathways, directly linking them to tumor heterogeneity. Deregulation of miRs can cause/control chemoresistance in other cancers, but in CCA their role is yet unclear. Thus, detailed characterization of miRs in CCA, focusing on their impact in drug resistance is urgently needed. Hence, I have 3 specific aims of this proposal: to 1) characterize the deregulated expression pattern of miRs involved in CCA pathogenesis and integrate this data with transcriptomes obtained from matched patients; 2) determine the role of deregulated miRs in control of chemoresistance, and 3) modulate by genome-editing key deregulated miR(s) targeting chemoresistant genes using the novel `CRISPR-Mir’ method. Achievement of these aims will yield key new insights into the role of miRs in orchestrating CCA progression and metastasis, as well as their involvement in drug resistance. My findings will have an impact on the society and in particular in patient outcome. Dr. Andersen, a world-wide expert in the molecular pathogenesis of CCA with a vast experience in genome medicine, will supervise the project. Successful completion of this proposal will enable me to expand my scientific expertise (plus technical and transferable skills) and to establish myself as an independent researcher in hepatobiliary and translational research.

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The information about "MIRCHOL" are provided by the European Opendata Portal: CORDIS opendata.

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