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PhotoNanoBone SIGNED

Photoresponsive Smart Nanocarriers for Tetherless Regeneration of Bone Tissue

Total Cost €

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EC-Contrib. €

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Partnership

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 PhotoNanoBone project word cloud

Explore the words cloud of the PhotoNanoBone project. It provides you a very rough idea of what is the project "PhotoNanoBone" about.

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Project "PhotoNanoBone" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://usc.es/ciqus/en/research/projects
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-01-02   to  2020-01-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 158˙121.00

Map

 Project objective

The research aim of PhotoNanoBone is to develop of a novel nanotechnological strategy based on stimuli-responsive nanocarriers together with a microfluidic platform for spatiotemporal control of cell reprogramming and differentiation of 3D cell cultures towards bone tissue engineering. The project entails three steps. (1) Synthesising stimuli-responsive nanocarriers by layer-by-layer assembly and loaded with cell reprogramming factors (cargo). Polymeric walls of nanocarriers will be further functionalized with magnetic and plasmonic nanoparticles. By applying magnetic fields, nanocarriers can be locally enrichment in 3D cell culture. Upon external light irradiation, plasmonic nanoparticles will be heated, leading to local opening of the polymeric walls and subsequent cargo release. (2) Set-up of a microfluidic platform for externally controlled intracellular magnetic targeting and light-triggered release of cargo. (3) Application of the developed technology in 3D cell cultures of fibroblasts (mouse model) for bone tissue engineering. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of PhotoNanoBone is to provide me with a truly solid formation in biomaterials, which will support my future career endeavors, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research center at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by two secondments focused on the following topics: synthesis of plasmonic NP with lasers (Complutense University Madrid) and development of microfluidic platforms (Micronit Michrotecnologies).

 Publications

year authors and title journal last update
List of publications.
2019 Carolina Carrillo-Carrión
Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms
published pages: , ISSN: 1618-2642, DOI: 10.1007/s00216-019-02217-y
Analytical and Bioanalytical Chemistry 2020-04-09
2019 Carolina Carrillo-Carrión, Raquel Martínez, María F. Navarro Poupard, Beatriz Pelaz, Ester Polo, Ana Arenas-Vivo, Alessandro Olgiati, Pablo Taboada, Mahmoud G. Soliman, Úrsula Catalán, Sara Fernández-Castillejo, Rosa Solà, Wolfgang J. Parak, Patricia Horcajada, Ramon A. Alvarez-Puebla, Pablo del Pino
Aqueous Stable Gold Nanostar/ZIF-8 Nanocomposites for Light-Triggered Release of Active Cargo Inside Living Cells
published pages: 7078-7082, ISSN: 1433-7851, DOI: 10.1002/anie.201902817
Angewandte Chemie International Edition 58/21 2020-04-09

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The information about "PHOTONANOBONE" are provided by the European Opendata Portal: CORDIS opendata.

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