PhotoNanoBone SIGNED
Photoresponsive Smart Nanocarriers for Tetherless Regeneration of Bone Tissue
Total Cost €
0EC-Contrib. €
0Partnership
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Project "PhotoNanoBone" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | https://usc.es/ciqus/en/research/projects |
| Total cost | 158˙121 € |
| EC max contribution | 158˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-02 to 2020-01-01 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSIDAD DE SANTIAGO DE COMPOSTELA | ES (SANTIAGO DE COMPOSTELA) | coordinator | 158˙121.00 |
Map
Project objective
The research aim of PhotoNanoBone is to develop of a novel nanotechnological strategy based on stimuli-responsive nanocarriers together with a microfluidic platform for spatiotemporal control of cell reprogramming and differentiation of 3D cell cultures towards bone tissue engineering. The project entails three steps. (1) Synthesising stimuli-responsive nanocarriers by layer-by-layer assembly and loaded with cell reprogramming factors (cargo). Polymeric walls of nanocarriers will be further functionalized with magnetic and plasmonic nanoparticles. By applying magnetic fields, nanocarriers can be locally enrichment in 3D cell culture. Upon external light irradiation, plasmonic nanoparticles will be heated, leading to local opening of the polymeric walls and subsequent cargo release. (2) Set-up of a microfluidic platform for externally controlled intracellular magnetic targeting and light-triggered release of cargo. (3) Application of the developed technology in 3D cell cultures of fibroblasts (mouse model) for bone tissue engineering. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of PhotoNanoBone is to provide me with a truly solid formation in biomaterials, which will support my future career endeavors, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research center at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by two secondments focused on the following topics: synthesis of plasmonic NP with lasers (Complutense University Madrid) and development of microfluidic platforms (Micronit Michrotecnologies).
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Carolina Carrillo-Carrión Nanoscale metal–organic frameworks as key players in the context of drug delivery: evolution toward theranostic platforms published pages: , ISSN: 1618-2642, DOI: 10.1007/s00216-019-02217-y |
Analytical and Bioanalytical Chemistry | 2020-04-09 |
| 2019 |
Carolina Carrillo-Carrión, Raquel MartÃnez, MarÃa F. Navarro Poupard, Beatriz Pelaz, Ester Polo, Ana Arenas-Vivo, Alessandro Olgiati, Pablo Taboada, Mahmoud G. Soliman, Úrsula Catalán, Sara Fernández-Castillejo, Rosa Solà , Wolfgang J. Parak, Patricia Horcajada, Ramon A. Alvarez-Puebla, Pablo del Pino Aqueous Stable Gold Nanostar/ZIF-8 Nanocomposites for Light-Triggered Release of Active Cargo Inside Living Cells published pages: 7078-7082, ISSN: 1433-7851, DOI: 10.1002/anie.201902817 |
Angewandte Chemie International Edition 58/21 | 2020-04-09 |
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