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RHAPSODY SIGNED

Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RHAPSODY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.imi-rhapsody.eu/
 Total cost 18˙488˙749 €
 EC max contribution 8˙130˙000 € (44%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-03-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 0.00
2    LUNDS UNIVERSITET SE (LUND) participant 1˙071˙853.00
3    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 748˙130.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 599˙151.00
5    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 518˙741.00
6    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) participant 518˙723.00
7    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 499˙121.00
8    ITA-SUOMEN YLIOPISTO FI (KUOPIO) participant 472˙587.00
9    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 468˙923.00
10    UNIVERSITE DE PARIS FR (PARIS) participant 418˙970.00
11    LIPOTYPE DE (DRESDEN) participant 418˙968.00
12    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 408˙745.00
13    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) participant 398˙395.00
14    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 389˙966.00
15    UNIVERSITA DI PISA IT (PISA) participant 389˙043.00
16    CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE FR (LILLE) participant 299˙296.00
17    STICHTING VUMC NL (AMSTERDAM) participant 149˙633.00
18    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 149˙632.00
19    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 105˙380.00
20    AZIENDA OSPEDALIERA CITTA DELLA SALUTE E DELLA SCIENZA DI TORINO IT (TORINO) participant 104˙743.00
21    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
22    INSTITUT DE RECHERCHES SERVIER FR (SURESNES) participant 0.00
23    JANSSEN PHARMACEUTICA NV BE (BEERSE) participant 0.00
24    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00
25    SANOFI-AVENTIS DEUTSCHLAND GMBH DE (FRANKFURT AM MAIN) participant 0.00
26    SCIPROM SARL CH (SAINT SULPICE) participant 0.00
27    SIB INSTITUT SUISSE DE BIOINFORMATIQUE CH (GENEVE) participant 0.00
28    UNIVERSITE PARIS DIDEROT - PARIS 7 FR (PARIS) participant 0.00

Map

 Project objective

The stated goal of RHAPSODY is to define a molecular taxonomy of type 2 diabetes mellitus (T2D) that will support patient segmentation, inform clinical trial design, and the establishment of regulatory paths for the adoption of novel strategies for diabetes prevention and treatment. To address these goals, RHAPSODY will bring together prominent European experts, including the leaders of the diabetes-relevant IMI1 projects to identify, validate and characterize causal biomarkers for T2D subtypes and progression. Our plans are built upon: (a) access to large European cohorts with comprehensive genetic analyses and rich longitudinal clinical and biochemical data and samples; (b) detailed multi-omic maps of key T2D-relevant tissues and organs; (c) large expertise in the development and use of novel genetic, epigenetic, biochemical and physiological experimental approaches; (d) the ability to combine existing and novel data sets through effective data federation and use of these datasets in systems biology approaches towards precision medicine; and (e) expertise in regulatory approval, health economics and patient engagement. These activities will lead to the discovery of novel biomarkers for improved T2D taxonomy, to support development of pharmaceutical activities, and for use in precision medicine to improve health in Europe and worldwide.

 Deliverables

List of deliverables.
Assessment of insulin action and secretion in preclinical models Documents, reports 2020-02-19 14:08:31
Project flyer Websites, patent fillings, videos etc. 2020-02-19 14:08:31
Website Websites, patent fillings, videos etc. 2020-02-19 14:08:31

Take a look to the deliverables list in detail:  detailed list of RHAPSODY deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien
The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis
published pages: , ISSN: , DOI: 10.1101/2020.03.25.007286
2020-04-24
2020 Thomas J. Clough, Nicoleta Baxan, Emma J. Coakley, Charlotte Rivas, Lan Zhao, Isabelle Leclerc, Aida Martinez-Sanchez, Guy A. Rutter, Nicholas J. Long
Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas
published pages: 4732-4740, ISSN: 1477-9226, DOI: 10.1039/d0dt00332h
Dalton Transactions 49/15 2020-04-24
2020 Masaya Oshima, Séverine Pechberty, Lara Bellini, Sven O. Göpel, Mélanie Campana, Claude Rouch, Julien Dairou, Cristina Cosentino, Federica Fantuzzi, Sanna Toivonen, Piero Marchetti, Christophe Magnan, Miriam Cnop, Hervé Le Stunff, Raphaël Scharfmann
Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity
published pages: 395-409, ISSN: 0012-186X, DOI: 10.1007/s00125-019-05046-x
Diabetologia 63/2 2020-04-24
2019 Raphael Scharfmann, Willem Staels, Olivier Albagli
The supply chain of human pancreatic β cell lines
published pages: 3511-3520, ISSN: 0021-9738, DOI: 10.1172/jci129484
Journal of Clinical Investigation 129/9 2020-04-24
2020 Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Klf6 protects β-cells against insulin resistance-induced dedifferentiation
published pages: 100958, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2020.02.001
Molecular Metabolism 35 2020-04-24
2019 Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo
published pages: 615-629, ISSN: 2522-5812, DOI: 10.1038/s42255-019-0075-2
Nature Metabolism 1/6 2020-04-24
2019 Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
NACHO: a Nanostring nCounter data QC package
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz647
Bioinformatics 2020-02-19
2019 Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor
published pages: 521351, ISSN: 0021-9258, DOI: 10.1101/521351
bioRxiv 2020-02-19
2018 Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
published pages: 361-369, ISSN: 2213-8587, DOI: 10.1016/s2213-8587(18)30051-2
The Lancet Diabetes & Endocrinology 6/5 2020-02-19
2019 Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes
published pages: , ISSN: 2212-8778, DOI: 10.1016/j.molmet.2019.03.004
Molecular Metabolism 2020-02-19
2019 Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure
published pages: , ISSN: 1945-7170, DOI: 10.1210/en.2019-00098
Endocrinology 2020-02-19
2019 Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Decision models of prediabetes populations: A systematic review
published pages: , ISSN: 1462-8902, DOI: 10.1111/dom.13684
Diabetes, Obesity and Metabolism 2020-02-19
2017 Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Local and regional control of calcium dynamics in the pancreatic islet
published pages: 30-41, ISSN: 1462-8902, DOI: 10.1111/dom.12990
Diabetes, Obesity and Metabolism 19 2020-02-19
2018 Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes
published pages: 10302-10318, ISSN: 0305-1048, DOI: 10.1093/nar/gky839
Nucleic Acids Research 46/19 2020-02-19
2018 Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele Solimena, Hans-Ulrich Häring, Susanne Ullrich, Robert Wagner
The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans
published pages: 4373-4383, ISSN: 0021-972X, DOI: 10.1210/jc.2018-00791
The Journal of Clinical Endocrinology & Metabolism 103/12 2020-02-19
2018 Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?
published pages: 40-45, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.002
Current Opinion in Pharmacology 43 2020-02-19
2017 Mark I. McCarthy
Painting a new picture of personalised medicine for diabetes
published pages: 793-799, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4210-x
Diabetologia 60/5 2020-02-19
2018 Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test
published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2018.00082
Frontiers in Endocrinology 9 2020-02-19
2017 Paul W Franks, Alaitz Poveda
Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?
published pages: 784-792, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4207-5
Diabetologia 60/5 2020-02-19
2018 Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells
published pages: 461-472, ISSN: 0012-1797, DOI: 10.2337/db17-0595
Diabetes 67/3 2020-02-19
2018 Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Modeling human pancreatic beta cell dedifferentiation
published pages: 74-86, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2018.02.002
Molecular Metabolism 10 2020-02-19
2017 Aida Martinez-Sanchez, Marie-Sophie Nguyen-Tu, Isabelle Leclerc, Guy A. Rutter
Manipulation and Measurement of AMPK activity in pancreatic islets
published pages: 413-431, ISSN: , DOI: 10.1007/978-1-4939-7598-3_26
2020-02-19
2017 Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
published pages: 1024-1039, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.06.001
Molecular Metabolism 6/9 2020-02-19
2017 Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Lifestyle precision medicine: the next generation in type 2 diabetes prevention?
published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0938-x
BMC Medicine 15/1 2020-02-19
2017 Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Computer simulation models of pre-diabetes populations: a systematic review protocol
published pages: e014954, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2016-014954
BMJ Open 7/10 2020-02-19
2018 Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes
published pages: 138-146, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4467-0
Diabetologia 61/1 2020-02-19

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