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ADDIA SIGNED

Validation of a fast and simple peripheral blood diagnostic biomarker kit for Alzheimer’s disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 ADDIA project word cloud

Explore the words cloud of the ADDIA project. It provides you a very rough idea of what is the project "ADDIA" about.

holds    japan    blood    kit    2    america    risky    commercialization    enrol    weeks    ivd    fast    intellectual    inexpensive    medical    annually    tests    diagnose    centres    previously    examination    exists    validated    patient    400    definite    autopsy    assay    introduction    formally    committed    healthcare    company    800    pop    imaging    patients    single    questionable    monitoring    cerebrospinal    million    diagnosis    puncture    usually    detect    ad    disease    ce    proven    neuropsychological    treatment    human    economy    consequently    organisation    urgent    lumbar    alzheimer    procedure    performed    biomarker    property    amoneta    performance    addia    scientifically    performing    diagnostics    ready    diagnostic    initial    clinical    subjects    registered    quality    innovative    months    validate    expensive    probes    proof    diagnosed    invasive    cytometry    meet    biomarkers    combination    life    drug    efficacy    market    small    fluorescent    flow    brain    sme    french    successful    amounts    fluid   

Project "ADDIA" data sheet

The following table provides information about the project.

Coordinator		 AMONETA DIAGNOSTICS 

Organization address
address: 17 RUE DU FORT
city: HUNINGUE
postcode: 68330
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website http://www.addia-project-h2020.eu
 Total cost 4˙998˙625 €
 EC max contribution 4˙998˙625 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AMONETA DIAGNOSTICS FR (HUNINGUE) coordinator 4˙998˙625.00

Map

 Project objective

The French SME Amoneta Diagnostics has previously developed a diagnostic kit for Alzheimer’s disease (AD) based on two blood biomarkers that are scientifically proven to be associated with AD. The company holds the intellectual property for specific fluorescent probes that can detect these biomarkers in small amounts of blood using flow cytometry. Currently, no single test to diagnose AD exists. A potential AD diagnosis is usually given by a combination of clinical examination, neuropsychological tests and brain imaging over weeks/months. A lumbar puncture can be performed to detect biomarkers in cerebrospinal fluid, but this procedure is risky and expensive. A definite AD diagnosis can formally only be given by autopsy. Consequently, the diagnosis is assessed late and still questionable. The novel kit allows the diagnosis of AD, using only one single test, in a fast, non-invasive and inexpensive way. We expect the blood-based biomarker kit to facilitate assessment of drug efficacy in AD drug development and the monitoring of treatment efficacy in AD patients. This kit will meet the urgent medical need of ~2 million patients in Europe, Japan and America, that are annually diagnosed with AD. Successful implementation will have a strong impact on the quality of life of patients and a significant impact on the healthcare system and economy. In this project, Amoneta Diagnostics will validate this diagnostic test by performing a Proof-of-Performance (PoP) clinical study in 800 human subjects including 400 AD patients. At the end of this 3-year project, a validated and CE registered IVD biomarker assay will be available and ready for clinical application. This innovative ADDIA biomarker assay will be ready for initial market introduction and further commercialization and implementation. The project is supported by patient organisation Alzheimer Europe, and several leading European Alzheimer centres that are committed to enrol subjects for the PoP clinical study.

 Deliverables

List of deliverables.
Scientific papers prepared for peer-reviewed open access journals Documents, reports 2019-11-11 10:17:23
Letters and project updates to patient organisation Alzheimer Europe Documents, reports 2019-11-11 10:17:23

Take a look to the deliverables list in detail:  detailed list of ADDIA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Bruno Dubois, MD, PhD, Professor, Jean-Christophe Bier, MD, Frederic Blanc, MD, PhD, Renaud David, MD, PhD, Jean-François Démonet, MD, PhD, Hüseyin Firat, MD, PhD, Giovanni B Frisoni, Prof, PhD, MD, Audrey Gabelle, MD, PhD, Hakan I. Gurvit, MD, Adrian Ivanoiu, MD, PhD, Eloi Magnin, MD, PhD, Moira Marizzoni, PhD, Saliha Moussaoui, PhD, Florence Pasquier, MD PhD and François Sellal, MD
Addia, a Multi- Center Clinical Study of Proof-of-Performance to Validate Blood-BasedBiomarkers for the Diagnostic of Alzheimer’s Disease (AD): The Study Protocol.
published pages: , ISSN: , DOI: 		2019-08-29
2019 F. Blanc, F. Giovanni, M. Marizzoni, C. Mutter, J.C. Bier, F. Sellal, J.F. Démonet, S. Boutillier, H. Firat, S. Moussaoui, R. David, A. Ivanoiu, E. Magnin, A. Gabelle, F. Pasquier, H. Gurvit, B. Dubois
ADDIA Chronobiology Study and Proof-of-Performance Study to Validate Blood-Based Biomarkers for the Diagnostic of early Alzheimer’s Disease (AD)
published pages: , ISSN: , DOI: 		2019-08-29

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The information about "ADDIA" are provided by the European Opendata Portal: CORDIS opendata.

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