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ADDIA SIGNED

Validation of a fast and simple peripheral blood diagnostic biomarker kit for Alzheimer’s disease

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Outcomes and results

 ADDIA project word cloud

Explore the words cloud of the ADDIA project. It provides you a very rough idea of what is the project "ADDIA" about.

diagnostic    procedure    ad    performance    previously    fast    intellectual    expensive    usually    examination    detect    fluorescent    400    monitoring    diagnosed    questionable    flow    invasive    successful    centres    scientifically    autopsy    addia    blood    validate    diagnose    months    validated    japan    proof    clinical    small    patient    biomarker    patients    company    cerebrospinal    performing    america    commercialization    cytometry    registered    amoneta    annually    subjects    urgent    drug    million    2    committed    fluid    combination    diagnostics    formally    neuropsychological    weeks    800    ce    treatment    single    lumbar    probes    property    kit    medical    initial    healthcare    tests    biomarkers    sme    quality    risky    assay    holds    economy    pop    ready    amounts    disease    organisation    alzheimer    introduction    human    performed    life    enrol    market    proven    brain    imaging    french    innovative    exists    definite    puncture    diagnosis    meet    efficacy    inexpensive    consequently    ivd   

Project "ADDIA" data sheet

The following table provides information about the project.

Coordinator		 AMONETA DIAGNOSTICS 

Organization address
address: 17 RUE DU FORT
city: HUNINGUE
postcode: 68330
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country France [FR]
 Project website http://www.addia-project-h2020.eu
 Total cost 4˙998˙625 €
 EC max contribution 4˙998˙625 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-2-2014
 Funding Scheme SME-2
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2019-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AMONETA DIAGNOSTICS FR (HUNINGUE) coordinator 4˙998˙625.00

Map

 Project objective

The French SME Amoneta Diagnostics has previously developed a diagnostic kit for Alzheimer’s disease (AD) based on two blood biomarkers that are scientifically proven to be associated with AD. The company holds the intellectual property for specific fluorescent probes that can detect these biomarkers in small amounts of blood using flow cytometry. Currently, no single test to diagnose AD exists. A potential AD diagnosis is usually given by a combination of clinical examination, neuropsychological tests and brain imaging over weeks/months. A lumbar puncture can be performed to detect biomarkers in cerebrospinal fluid, but this procedure is risky and expensive. A definite AD diagnosis can formally only be given by autopsy. Consequently, the diagnosis is assessed late and still questionable. The novel kit allows the diagnosis of AD, using only one single test, in a fast, non-invasive and inexpensive way. We expect the blood-based biomarker kit to facilitate assessment of drug efficacy in AD drug development and the monitoring of treatment efficacy in AD patients. This kit will meet the urgent medical need of ~2 million patients in Europe, Japan and America, that are annually diagnosed with AD. Successful implementation will have a strong impact on the quality of life of patients and a significant impact on the healthcare system and economy. In this project, Amoneta Diagnostics will validate this diagnostic test by performing a Proof-of-Performance (PoP) clinical study in 800 human subjects including 400 AD patients. At the end of this 3-year project, a validated and CE registered IVD biomarker assay will be available and ready for clinical application. This innovative ADDIA biomarker assay will be ready for initial market introduction and further commercialization and implementation. The project is supported by patient organisation Alzheimer Europe, and several leading European Alzheimer centres that are committed to enrol subjects for the PoP clinical study.

 Deliverables

List of deliverables.
Scientific papers prepared for peer-reviewed open access journals Documents, reports 2019-11-11 10:17:23
Letters and project updates to patient organisation Alzheimer Europe Documents, reports 2019-11-11 10:17:23

Take a look to the deliverables list in detail:  detailed list of ADDIA deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Bruno Dubois, MD, PhD, Professor, Jean-Christophe Bier, MD, Frederic Blanc, MD, PhD, Renaud David, MD, PhD, Jean-François Démonet, MD, PhD, Hüseyin Firat, MD, PhD, Giovanni B Frisoni, Prof, PhD, MD, Audrey Gabelle, MD, PhD, Hakan I. Gurvit, MD, Adrian Ivanoiu, MD, PhD, Eloi Magnin, MD, PhD, Moira Marizzoni, PhD, Saliha Moussaoui, PhD, Florence Pasquier, MD PhD and François Sellal, MD
Addia, a Multi- Center Clinical Study of Proof-of-Performance to Validate Blood-BasedBiomarkers for the Diagnostic of Alzheimer’s Disease (AD): The Study Protocol.
published pages: , ISSN: , DOI: 		2019-08-29
2019 F. Blanc, F. Giovanni, M. Marizzoni, C. Mutter, J.C. Bier, F. Sellal, J.F. Démonet, S. Boutillier, H. Firat, S. Moussaoui, R. David, A. Ivanoiu, E. Magnin, A. Gabelle, F. Pasquier, H. Gurvit, B. Dubois
ADDIA Chronobiology Study and Proof-of-Performance Study to Validate Blood-Based Biomarkers for the Diagnostic of early Alzheimer’s Disease (AD)
published pages: , ISSN: , DOI: 		2019-08-29

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The information about "ADDIA" are provided by the European Opendata Portal: CORDIS opendata.

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