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EbolaMoDRAD SIGNED

Ebola Virus: Modern Approaches for developing bedside Rapid Diagnostics – Sofia ref.: 115843

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EbolaMoDRAD project word cloud

Explore the words cloud of the EbolaMoDRAD project. It provides you a very rough idea of what is the project "EbolaMoDRAD" about.

public africa deadly december recover correctly performance medical culture trained november insecurity units 15000 ebov molecular infections war individuals standard spreading slum disease 2014 outbreak deaths populated diagnostic international city guinea care mid actions national outbreaks struggling disruption first sierra performing limit infected few mobile social laboratories overwhelmingly unfortunately diagnosis stop countries specialist laboratory centres direct canadian serious rural limited 11 ebola functions crisis parts serological consequently usa health hubs virus patients tests mobilised evd african isolate 5000 2013 helping epidemic rapid skill cdc densely spread caused staff chinese west decades performed training workers approximately healthcare reference liberia months leone severely

Project "EbolaMoDRAD" data sheet

The following table provides information about the project.

Coordinator	FOLKHALSOMYNDIGHETEN Organization address address: NOBELS VAG 18 city: SOLNA postcode: 171 82 website: http://folkhalsomyndigheten.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.ebolamodrad.eu/
Total cost	4˙300˙935 €
EC max contribution	4˙300˙935 € (100%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2014-02-single-stage
Funding Scheme	IMI2-RIA
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2018-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FOLKHALSOMYNDIGHETEN FOLKHALSOMYNDIGHETEN Organization address address: NOBELS VAG 18 city: SOLNA postcode: 171 82 website: http://folkhalsomyndigheten.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SOLNA)	coordinator	416˙666.00
2	CORIS BIOCONCEPT SPRL CORIS BIOCONCEPT SPRL Organization address address: RUE JEAN SONET 4A PARC SCIENTIFIQUE CREALYS LES ISNES city: GEMBLOUX postcode: 5032 website: http://www.corisbio.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GEMBLOUX)	participant	318˙125.00
3	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	312˙500.00
4	Department of Health Department of Health Organization address address: Quarry House, Quarry Hill city: Leeds postcode: LS2 7UE website: www.dh.gov.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Leeds)	participant	310˙625.00
5	ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO Organization address address: Via Portuense, 292 city: ROMA postcode: 149 website: www.inmi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	308˙750.00
6	THE UNIVERSITY OF STIRLING THE UNIVERSITY OF STIRLING Organization address address: . city: STIRLING postcode: FK9 4LA website: www.stir.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (STIRLING)	participant	279˙836.00
7	CLONIT SRL CLONIT SRL Organization address address: Via Varese 20 city: MILANO postcode: 20121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	251˙250.00
8	INSERM - TRANSFERT SA INSERM - TRANSFERT SA Organization address address: RUE WATT 7 city: PARIS postcode: 75013 website: www.inserm-transfert.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	231˙000.00
9	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	224˙106.00
10	INSTITUT PASTEUR DE DAKAR INSTITUT PASTEUR DE DAKAR Organization address address: AVENUE PASTEUR 36 city: DAKAR postcode: DAKAR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SN (DAKAR)	participant	216˙250.00
11	STATENS SERUM INSTITUT STATENS SERUM INSTITUT Organization address address: ARTILLERIVEJ 5 city: KOBENHAVN S postcode: 2300 website: www.ssi.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN S)	participant	208˙375.00
12	UNIVERSITE D'AIX MARSEILLE UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marseille)	participant	207˙084.00
13	STOCKHOLMS UNIVERSITET STOCKHOLMS UNIVERSITET Organization address address: UNIVERSITETSVAGEN 10 city: STOCKHOLM postcode: 10691 website: www.su.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	207˙000.00
14	EMERGENCY LIFE SUPPORT FOR CIVILIAN WAR VICTIMS ONG ONLUS EMERGENCY LIFE SUPPORT FOR CIVILIAN WAR VICTIMS ONG ONLUS Organization address address: VIA SANTA CROCE 19 city: MILANO postcode: 20122 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	200˙078.00
15	AJ INNUSCREEN GMBH AJ INNUSCREEN GMBH Organization address address: ROBERT ROSSLE STR 10 city: BERLIN postcode: 13125 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	175˙000.00
16	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	173˙040.00
17	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	146˙250.00
18	TURUN YLIOPISTO TURUN YLIOPISTO Organization address address: YLIOPISTONMAKI city: Turku postcode: 20014 website: www.utu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Turku)	participant	115˙000.00

Map

Project objective

The current Ebola Virus Disease (EVD) outbreak has caused more than 5000 deaths within a few months in West Africa (Guinea, Sierra Leone and Liberia being the most severely affected countries), including numerous healthcare workers. It is now is serious public health crisis of international concern . The numbers of cases are still increasing 11 months after the first case was described (December 2013), by mid November 2014 approximately 15000 individuals have been infected and the epidemic is still not under control The direct effects of this outbreak include disruption of standard medical care, insecurity and social disruption in countries that were already struggling to recover from decades of war. One of the most important key actions to limit and stop the spread of this deadly disease is to identify and isolate the EBOV-infected patients. The diagnosis of Ebola Virus infections has in the past, been performed overwhelmingly in specialist reference laboratories with high-performance molecular, serological and culture methods.In recent years many of these functions have been mobilised into rapid response mobile laboratories, indeed several of these units supported by, European, CDC/USA, Canadian, Chinese and African states have been set up to help in the current outbreak by performing laboratory diagnosis, in collaboration with national centres in West Africa. While this type of response has been effective in helping control past EVD outbreaks in rural parts of Africa, it has not been as effective at controlling the current outbreak which is now spreading in densely populated city and slum areas. Unfortunately, the diagnostic procedures currently used in the mobile laboratories are associated with several problems: i) there are a limited number of diagnostic hubs, ii) performing the diagnostic tests correctly requires specialist training, skill and experience, consequently there a limited numbers of trained staff

Deliverables

List of deliverables.
Field usable filer tipp based RNA extraction	Demonstrators, pilots, prototypes	2019-06-19 14:40:34
Validation and field trials report	Documents, reports	2019-06-19 14:40:34
Validate QRT-PCR assays	Documents, reports	2019-06-19 14:40:34
Report on course/workshop on outbreak management	Documents, reports	2019-06-19 14:40:34
Report on course/workshop in field diagnostic	Documents, reports	2019-06-19 14:40:34
Report on course/workshop on clinical aspects of emerging disease	Documents, reports	2019-06-19 14:40:34
Design, develop and validate isothermal detection assays based on RPA, LAMP and hRCA technology	Documents, reports	2019-06-19 14:40:34
Design, develop and validate Ebola detection in an automated and closed system	Demonstrators, pilots, prototypes	2019-06-19 14:40:34

Take a look to the deliverables list in detail: detailed list of EbolaMoDRAD deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	F. Colavita, M. Biava, P. Mertens, Q. Gilleman, C. Borlon, M. Delli Guanti, A. Petrocelli, G. Cataldi, A.T. Kamara, S.A. Kamara, K. Konneh, D. Vincenti, C. Castilletti, S. Abdurahman, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro EBOLA Ag K -SeT rapid test: field evaluation in Sierra Leone published pages: 653-657, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2017.10.019	Clinical Microbiology and Infection 24/6	2019-06-19
2017	Christian Risinger, Kasper K. SÃ¸rensen, Knud J. Jensen, Sigvard Olofsson, Tomas BergstrÃ¶m, Ola Blixt Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections published pages: 360-367, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.7b00001	ACS Infectious Diseases 3/5	2019-06-19
2017	Felix He, Krister MelÃ©n, Sari Maljanen, Rickard Lundberg, Miao Jiang, Pamela Ã–sterlund, Laura Kakkola, Ilkka Julkunen Ebolavirus protein VP24 interferes with innate immune responses by inhibiting interferon-Î»1 gene expression published pages: 23-34, ISSN: 0042-6822, DOI: 10.1016/j.virol.2017.06.002	Virology 509	2019-06-19
2017	GÃ©raldine Piorkowski, FrÃ©dÃ©ric Jacquot, Gilles QuÃ©rat, Caroline Carbonnelle, Delphine Pannetier, France MentrÃ©, HervÃ© Raoul, Xavier de Lamballerie Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations published pages: 95-105, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.01.017	Antiviral Research 140	2019-06-19
2018	M. Biava, F. Colavita, A. Marzorati, D. Russo, D. Pirola, A. Cocci, A. Petrocelli, M. Delli Guanti, G. Cataldi, T.A. Kamara, A.S. Kamara, K. Konneh, A. Cannas, S. Coen, S. Quartu, S. Meschi, M.B. Valli, A. Mazzarelli, C. Venditti, G. Grassi, G. Rozera, C. Castilletti, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro Evaluation of a rapid and sensitive RT-qPCR assay for the detection of Ebola Virus published pages: 70-74, ISSN: 0166-0934, DOI: 10.1016/j.jviromet.2017.11.009	Journal of Virological Methods 252	2019-06-19
2017	Jorma Hinkula, StÃ©phanie Devignot, Sara Ã…kerstrÃ¶m, Helen Karlberg, Eva Wattrang, SÃ¡ndor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice published pages: e02076-16, ISSN: 0022-538X, DOI: 10.1128/JVI.02076-16	Journal of Virology 91/10	2019-06-19
2017	S. Carinelli, M. KÃ¼hnemund, M. Nilsson, M.I. Pividori Yoctomole electrochemical genosensing of Ebola virus cDNA by rolling circle and circle to circle amplification published pages: 65-71, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.09.099	Biosensors and Bioelectronics 93	2019-06-19
2018	JÃ©rÃ©mie Guedj, GÃ©raldine Piorkowski, FrÃ©dÃ©ric Jacquot, Vincent Madelain, Thi Huyen Tram Nguyen, Anne Rodallec, Stephan Gunther, Caroline Carbonnelle, France MentrÃ©, HervÃ© Raoul, Xavier de Lamballerie Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques published pages: e1002535, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002535	PLOS Medicine 15/3	2019-06-19
2017	Tomasz Krzywkowski, Mats Nilsson Fidelity of RNA templated end-joining by chlorella virus DNA ligase and a novel iLock assay with improved direct RNA detection accuracy published pages: e161-e161, ISSN: 0305-1048, DOI: 10.1093/nar/gkx708	Nucleic Acids Research 45/18	2019-06-19
2018	Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, BjÃ¶rn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer published pages: e0191872, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191872	PLOS ONE 13/2	2019-06-19
2017	Malte KÃ¼hnemund, IvÃ¡n HernÃ¡ndez-Neuta, MohdÂ Istiaq Sharif, Matteo Cornaglia, Martin A.M. Gijs, Mats Nilsson Sensitive and inexpensive digital DNA analysis by microfluidic enrichment of rolling circle amplified single-molecules published pages: gkw1324, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1324	Nucleic Acids Research 45(8)	2019-06-19
2017	Nicolai Stuhr-Hansen, Christian Risinger, Ebbe Engholm, Ola Blixt Synthesis of Oligo-(alkyne-triplet)peptide Constructs published pages: 6522-6525, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b03231	Organic Letters 19/24	2019-06-19
2017	Francesca Colavita, Mirella Biava, Concetta Castilletti, Serena Quartu, Francesco Vairo, Claudia Caglioti, Chiara Agrati, Eleonora Lalle, Licia Bordi, Simone Lanini, Michela Delli Guanti, Rossella Miccio, Giuseppe Ippolito, Maria R. Capobianchi, Antonino Di Caro Measles Cases during Ebola Outbreak, West Africa, 2013â€“2106 published pages: 1035-1037, ISSN: 1080-6040, DOI: 10.3201/eid2306.161682	Emerging Infectious Diseases 23/6	2019-06-19

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