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Ebola Virus: Modern Approaches for developing bedside Rapid Diagnostics – Sofia ref.: 115843

Total Cost €


EC-Contrib. €






 EbolaMoDRAD project word cloud

Explore the words cloud of the EbolaMoDRAD project. It provides you a very rough idea of what is the project "EbolaMoDRAD" about.

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Project "EbolaMoDRAD" data sheet

The following table provides information about the project.


Organization address
address: NOBELS VAG 18
city: SOLNA
postcode: 171 82

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 4˙300˙935 €
 EC max contribution 4˙300˙935 € (100%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2014-02-single-stage
 Funding Scheme IMI2-RIA
 Starting year 2015
 Duration (year-month-day) from 2015-02-01   to  2018-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FOLKHALSOMYNDIGHETEN SE (SOLNA) coordinator 416˙666.00
2    CORIS BIOCONCEPT SPRL BE (GEMBLOUX) participant 318˙125.00
3    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 312˙500.00
4    Department of Health UK (Leeds) participant 310˙625.00
6    THE UNIVERSITY OF STIRLING UK (STIRLING) participant 279˙836.00
7    CLONIT SRL IT (MILANO) participant 251˙250.00
8    INSERM - TRANSFERT SA FR (PARIS) participant 231˙000.00
10    INSTITUT PASTEUR DE DAKAR SN (DAKAR) participant 216˙250.00
11    STATENS SERUM INSTITUT DK (KOBENHAVN S) participant 208˙375.00
12    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 207˙084.00
13    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 207˙000.00
15    AJ INNUSCREEN GMBH DE (BERLIN) participant 175˙000.00
16    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 173˙040.00
18    TURUN YLIOPISTO FI (Turku) participant 115˙000.00


 Project objective

The current Ebola Virus Disease (EVD) outbreak has caused more than 5000 deaths within a few months in West Africa (Guinea, Sierra Leone and Liberia being the most severely affected countries), including numerous healthcare workers. It is now is serious public health crisis of international concern . The numbers of cases are still increasing 11 months after the first case was described (December 2013), by mid November 2014 approximately 15000 individuals have been infected and the epidemic is still not under control The direct effects of this outbreak include disruption of standard medical care, insecurity and social disruption in countries that were already struggling to recover from decades of war. One of the most important key actions to limit and stop the spread of this deadly disease is to identify and isolate the EBOV-infected patients. The diagnosis of Ebola Virus infections has in the past, been performed overwhelmingly in specialist reference laboratories with high-performance molecular, serological and culture methods.In recent years many of these functions have been mobilised into rapid response mobile laboratories, indeed several of these units supported by, European, CDC/USA, Canadian, Chinese and African states have been set up to help in the current outbreak by performing laboratory diagnosis, in collaboration with national centres in West Africa. While this type of response has been effective in helping control past EVD outbreaks in rural parts of Africa, it has not been as effective at controlling the current outbreak which is now spreading in densely populated city and slum areas. Unfortunately, the diagnostic procedures currently used in the mobile laboratories are associated with several problems: i) there are a limited number of diagnostic hubs, ii) performing the diagnostic tests correctly requires specialist training, skill and experience, consequently there a limited numbers of trained staff


List of deliverables.
Field usable filer tipp based RNA extraction Demonstrators, pilots, prototypes 2019-06-19 14:40:34
Validation and field trials report Documents, reports 2019-06-19 14:40:34
Validate QRT-PCR assays Documents, reports 2019-06-19 14:40:34
Report on course/workshop on outbreak management Documents, reports 2019-06-19 14:40:34
Report on course/workshop in field diagnostic Documents, reports 2019-06-19 14:40:34
Report on course/workshop on clinical aspects of emerging disease Documents, reports 2019-06-19 14:40:34
Design, develop and validate isothermal detection assays based on RPA, LAMP and hRCA technology Documents, reports 2019-06-19 14:40:34
Design, develop and validate Ebola detection in an automated and closed system Demonstrators, pilots, prototypes 2019-06-19 14:40:34

Take a look to the deliverables list in detail:  detailed list of EbolaMoDRAD deliverables.


year authors and title journal last update
List of publications.
2018 F. Colavita, M. Biava, P. Mertens, Q. Gilleman, C. Borlon, M. Delli Guanti, A. Petrocelli, G. Cataldi, A.T. Kamara, S.A. Kamara, K. Konneh, D. Vincenti, C. Castilletti, S. Abdurahman, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro
EBOLA Ag K -SeT rapid test: field evaluation in Sierra Leone
published pages: 653-657, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2017.10.019
Clinical Microbiology and Infection 24/6 2019-06-19
2017 Christian Risinger, Kasper K. Sørensen, Knud J. Jensen, Sigvard Olofsson, Tomas Bergström, Ola Blixt
Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections
published pages: 360-367, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.7b00001
ACS Infectious Diseases 3/5 2019-06-19
2017 Felix He, Krister Melén, Sari Maljanen, Rickard Lundberg, Miao Jiang, Pamela Österlund, Laura Kakkola, Ilkka Julkunen
Ebolavirus protein VP24 interferes with innate immune responses by inhibiting interferon-λ1 gene expression
published pages: 23-34, ISSN: 0042-6822, DOI: 10.1016/j.virol.2017.06.002
Virology 509 2019-06-19
2017 Géraldine Piorkowski, Frédéric Jacquot, Gilles Quérat, Caroline Carbonnelle, Delphine Pannetier, France Mentré, Hervé Raoul, Xavier de Lamballerie
Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations
published pages: 95-105, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.01.017
Antiviral Research 140 2019-06-19
2018 M. Biava, F. Colavita, A. Marzorati, D. Russo, D. Pirola, A. Cocci, A. Petrocelli, M. Delli Guanti, G. Cataldi, T.A. Kamara, A.S. Kamara, K. Konneh, A. Cannas, S. Coen, S. Quartu, S. Meschi, M.B. Valli, A. Mazzarelli, C. Venditti, G. Grassi, G. Rozera, C. Castilletti, A. Mirazimi, M.R. Capobianchi, G. Ippolito, R. Miccio, A. Di Caro
Evaluation of a rapid and sensitive RT-qPCR assay for the detection of Ebola Virus
published pages: 70-74, ISSN: 0166-0934, DOI: 10.1016/j.jviromet.2017.11.009
Journal of Virological Methods 252 2019-06-19
2017 Jorma Hinkula, Stéphanie Devignot, Sara Åkerström, Helen Karlberg, Eva Wattrang, Sándor Bereczky, Mehrdad Mousavi-Jazi, Christian Risinger, Gunnel Lindegren, Caroline Vernersson, Janusz Paweska, Petrus Jansen van Vuren, Ola Blixt, Alejandro Brun, Friedemann Weber, Ali Mirazimi
Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice
published pages: e02076-16, ISSN: 0022-538X, DOI: 10.1128/JVI.02076-16
Journal of Virology 91/10 2019-06-19
2017 S. Carinelli, M. Kühnemund, M. Nilsson, M.I. Pividori
Yoctomole electrochemical genosensing of Ebola virus cDNA by rolling circle and circle to circle amplification
published pages: 65-71, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.09.099
Biosensors and Bioelectronics 93 2019-06-19
2018 Jérémie Guedj, Géraldine Piorkowski, Frédéric Jacquot, Vincent Madelain, Thi Huyen Tram Nguyen, Anne Rodallec, Stephan Gunther, Caroline Carbonnelle, France Mentré, Hervé Raoul, Xavier de Lamballerie
Antiviral efficacy of favipiravir against Ebola virus: A translational study in cynomolgus macaques
published pages: e1002535, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1002535
PLOS Medicine 15/3 2019-06-19
2017 Tomasz Krzywkowski, Mats Nilsson
Fidelity of RNA templated end-joining by chlorella virus DNA ligase and a novel iLock assay with improved direct RNA detection accuracy
published pages: e161-e161, ISSN: 0305-1048, DOI: 10.1093/nar/gkx708
Nucleic Acids Research 45/18 2019-06-19
2018 Ulrika Wendel, Nina Persson, Christian Risinger, Eva Bengtsson, Björn Nodin, Lena Danielsson, Charlotte Welinder, Gunilla Nordin Fredrikson, Bo Jansson, Ola Blixt
A novel monoclonal antibody targeting carboxymethyllysine, an advanced glycation end product in atherosclerosis and pancreatic cancer
published pages: e0191872, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191872
PLOS ONE 13/2 2019-06-19
2017 Malte Kühnemund, Iván Hernández-Neuta, Mohd Istiaq Sharif, Matteo Cornaglia, Martin A.M. Gijs, Mats Nilsson
Sensitive and inexpensive digital DNA analysis by microfluidic enrichment of rolling circle amplified single-molecules
published pages: gkw1324, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1324
Nucleic Acids Research 45(8) 2019-06-19
2017 Nicolai Stuhr-Hansen, Christian Risinger, Ebbe Engholm, Ola Blixt
Synthesis of Oligo-(alkyne-triplet)peptide Constructs
published pages: 6522-6525, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b03231
Organic Letters 19/24 2019-06-19
2017 Francesca Colavita, Mirella Biava, Concetta Castilletti, Serena Quartu, Francesco Vairo, Claudia Caglioti, Chiara Agrati, Eleonora Lalle, Licia Bordi, Simone Lanini, Michela Delli Guanti, Rossella Miccio, Giuseppe Ippolito, Maria R. Capobianchi, Antonino Di Caro
Measles Cases during Ebola Outbreak, West Africa, 2013–2106
published pages: 1035-1037, ISSN: 1080-6040, DOI: 10.3201/eid2306.161682
Emerging Infectious Diseases 23/6 2019-06-19

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