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AB-DiRecT SIGNED

Antibiotic Distribution and Recovery in Tissue

Total Cost €

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EC-Contrib. €

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Partnership

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 AB-DiRecT project word cloud

Explore the words cloud of the AB-DiRecT project. It provides you a very rough idea of what is the project "AB-DiRecT" about.

pathogens    clinical    mechanism    levels    triazaacenaphthylene    vitro    urinary    animal    fluoroquinolones    model    conduct    plasma    oral    sites    subjects    urgent    pkpd    undergoing    negative    resistant    requiring    coli    threat    treatment    class    prostate    infected    acute    pbpk    urogenital    caused    active    surgery    gram    single    infection    body    contemporary    gepotidacin    classes    direct    gonorrhoeae    uncomplicated    healthcare    tissue    pk    action    health    determinants    models    antimicrobials    first    provision    pharyngeal    tonsil    prostatectomy    antibiotics    exposure    prostatitis    determined    gonorrhoea    antibacterials    data    elective    penetration    difference    regimens    isolates    tonsillectomy    selective    poppk    burden    efficacy    antimicrobial    explore    economic    positive    explored    gsk    tract    imposes    broad    agents    microdialysis    dose    trials    antibacterial    resistance    ab    discovery    infections    treat    understand    healthy   

Project "AB-DiRecT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙789˙717 €
 EC max contribution 3˙429˙217 € (90%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2018-16-single-stage
 Funding Scheme IMI2-RIA
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙234˙278.00
2    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) participant 1˙116˙375.00
3    CENTRE HOSPITALIER UNIVERSITAIRE DE POITIERS FR (POITIERS CEDEX) participant 539˙188.00
4    INSERM - TRANSFERT SA FR (PARIS) participant 335˙625.00
5    CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS FR (TOURS CEDEX 9) participant 203˙750.00
6    GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. UK (BRENTFORD) participant 0.00

Map

 Project objective

Antimicrobial resistance imposes an important health and economic burden with the threat of a future without effective antibiotics requiring major changes to contemporary healthcare provision. Therefore, the discovery and development of novel mechanism of action agents able to treat resistant infections is a key urgent need. Gepotidacin is a first in class, novel triazaacenaphthylene antibacterial that is being developed by GSK. Due to its novel mechanism of action, gepotidacin is active in vitro against most target pathogens carrying resistance determinants to established antibacterials, including fluoroquinolones. Gepotidacin has broad gram-positive activity and selective gram-negative activity and is currently under development as a treatment for infections caused by N. gonorrhoeae (urogenital gonorrhoea) and E. coli (acute uncomplicated urinary tract infections), including isolates resistant to existing classes of antimicrobials. To explore the potential of gepotidacin to treat infections caused by N. gonorrhoeae or E. coli at other body sites, the AB-DiRecT consortium will conduct a tissue distribution study in tonsil and prostate after single oral dose of gepotidacin in healthy (non-infected) subjects undergoing elective tonsillectomy or prostatectomy. Microdialysis will be used to measure gepotidacin levels in tissue following surgery and PBPK, PopPK and PKPD models will be built to understand the tissue penetration of gepotidacin to characterize exposure response and to evaluate different dose regimens. Difference between infected and healthy tissue will be explored in an animal prostatitis infection model where gepotidacin PK in plasma and tissue will be determined using microdialysis. Overall the data generated in AB-DiRecT may support the potential for clinical trials to determine the efficacy of gepotidacin for the treatment for pharyngeal N. gonorrhoeae infections and / or prostatitis caused by E. coli.

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