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CHI-ZEF SIGNED

Cdon-Hh Interaction: functional in vivo analysis in zebrafish

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CHI-ZEF project word cloud

Explore the words cloud of the CHI-ZEF project. It provides you a very rough idea of what is the project "CHI-ZEF" about.

cas9 border protein destiny shapes stalk functions tackle morphogenetic retina distal dispersion medicine participates malformations ocular operate vesicle responsible model congenital unprecedented questions tools patterning proximal neural eye boundary decoy crispr cdon follow specification receptor cells unrelated producing ultimately proximo hh expressed clinical protect arising molecule optic interaction release first zebrafish regenerative reverting cell acting promotes gradient generate controls vertebrate vivo accumulated signalling adhesion ventral diencephalic unanswered midline binds

Project "CHI-ZEF" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://f1000research.com/articles/7-1934/v1
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00

Map

Project objective

Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hh signalling, which promotes stalk specification. At the neural retina/optic stalk border, the cell adhesion molecule Cdon binds Hh, acting as a decoy receptor to protect the neural retina from Hh activity. How Cdon controls Hh dispersion, what is the destiny of the Hh protein accumulated at the neural retina/optic stalk boundary, whether Cdon participates in the release of Hh from its producing cells or whether Cdon has Hh-unrelated functions in the neural retina are the arising and still unanswered questions I aim to tackle in this proposal. Using the zebrafish as a model system and CRISPR/Cas9 technology I will first generate unprecedented tools to follow in vivo Cdon/Hh interaction, and then address how Cdon, expressed in both the ventral diencephalic midline and the neural retina, shapes the gradient of Hh responsible for proximo-distal patterning of the eye. I expect that the development of this proposal will provide significant advance on how morphogenetic signalling pathways operate, ultimately reverting into the field of regenerative medicine and clinical research related to congenital ocular malformations.

Publications

List of publications.
year	authors and title	journal	last update
2018	Viviana E Gallardo, Paola Bovolenta Positive and negative regulation of Shh signalling in vertebrate retinal development published pages: 1934, ISSN: 2046-1402, DOI: 10.12688/f1000research.16190.1	F1000Research 7	2019-08-29

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The information about "CHI-ZEF" are provided by the European Opendata Portal: CORDIS opendata.