Explore the words cloud of the CHI-ZEF project. It provides you a very rough idea of what is the project "CHI-ZEF" about.
The following table provides information about the project.
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
|Coordinator Country||Spain [ES]|
|Total cost||158˙121 €|
|EC max contribution||158˙121 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-07-01 to 2019-06-30|
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|1||AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS||ES (MADRID)||coordinator||158˙121.00|
Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hh signalling, which promotes stalk specification. At the neural retina/optic stalk border, the cell adhesion molecule Cdon binds Hh, acting as a decoy receptor to protect the neural retina from Hh activity. How Cdon controls Hh dispersion, what is the destiny of the Hh protein accumulated at the neural retina/optic stalk boundary, whether Cdon participates in the release of Hh from its producing cells or whether Cdon has Hh-unrelated functions in the neural retina are the arising and still unanswered questions I aim to tackle in this proposal. Using the zebrafish as a model system and CRISPR/Cas9 technology I will first generate unprecedented tools to follow in vivo Cdon/Hh interaction, and then address how Cdon, expressed in both the ventral diencephalic midline and the neural retina, shapes the gradient of Hh responsible for proximo-distal patterning of the eye. I expect that the development of this proposal will provide significant advance on how morphogenetic signalling pathways operate, ultimately reverting into the field of regenerative medicine and clinical research related to congenital ocular malformations.
|year||authors and title||journal||last update|
Viviana E Gallardo, Paola Bovolenta
Positive and negative regulation of Shh signalling in vertebrate retinal development
published pages: 1934, ISSN: 2046-1402, DOI: 10.12688/f1000research.16190.1
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The information about "CHI-ZEF" are provided by the European Opendata Portal: CORDIS opendata.
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