Opendata, web and dolomites

IDRAM TERMINATED

The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IDRAM project word cloud

Explore the words cloud of the IDRAM project. It provides you a very rough idea of what is the project "IDRAM" about.

compounds    responsible    understand    commonplace    lactone    classes    tools    livestock    cornerstone    function    link    poorly    unexplored    mechanism    food    fast    anthelmintics    elegans    parasitic    first    nematodes    efficient    lactones    teladorsagia    isolates    supplies    levamisole    man    infections    generate    mechanisms    broad    amphid    suggesting    veterinary    drugs    laboratory    haemonchus    heatlh    amphids    contortus    impeding    source    genomic    class    route    sensitive    significance    macrocyclic    apparently    nematode    model    organs    difficult    thorough    anthelmintic    treatment    mutations    sensory    spectrum    defects    contribution    amphidial    circumcincta    molecular    trichostrongyles    public    alleles    resistant    strategies    crops    resistance    direct    emergence    benzimidazole    mutants    drug    ivermectin    pave    health    imidazothiazole    limit    biochemical    techniques    albendazole    active    worldwide    phenotype    primary    hypothesize    exact    threatening   

Project "IDRAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IDRAM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IDRAM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More  

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More