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IDRAM TERMINATED

The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDRAM project word cloud

Explore the words cloud of the IDRAM project. It provides you a very rough idea of what is the project "IDRAM" about.

apparently    link    active    albendazole    model    fast    responsible    class    health    poorly    first    suggesting    function    levamisole    sensory    mutants    cornerstone    alleles    amphid    threatening    livestock    resistant    infections    defects    crops    anthelmintic    worldwide    treatment    route    sensitive    primary    mutations    phenotype    food    supplies    man    contortus    emergence    drug    contribution    spectrum    genomic    organs    techniques    generate    understand    strategies    limit    macrocyclic    circumcincta    haemonchus    classes    biochemical    pave    teladorsagia    public    ivermectin    significance    hypothesize    exact    benzimidazole    drugs    amphidial    heatlh    compounds    unexplored    commonplace    difficult    imidazothiazole    efficient    isolates    anthelmintics    lactone    tools    source    direct    nematode    resistance    trichostrongyles    broad    thorough    lactones    parasitic    amphids    mechanisms    mechanism    nematodes    molecular    veterinary    laboratory    elegans    impeding   

Project "IDRAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

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The information about "IDRAM" are provided by the European Opendata Portal: CORDIS opendata.

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