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IDRAM TERMINATED

The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDRAM project word cloud

Explore the words cloud of the IDRAM project. It provides you a very rough idea of what is the project "IDRAM" about.

spectrum    veterinary    anthelmintic    drug    mutations    difficult    phenotype    emergence    supplies    organs    lactone    contortus    link    understand    resistant    pave    public    poorly    function    food    teladorsagia    molecular    nematodes    elegans    fast    exact    generate    hypothesize    isolates    compounds    man    commonplace    apparently    macrocyclic    efficient    amphids    cornerstone    responsible    mechanism    classes    significance    defects    benzimidazole    ivermectin    biochemical    techniques    livestock    haemonchus    albendazole    amphid    health    lactones    source    imidazothiazole    heatlh    anthelmintics    contribution    drugs    sensitive    circumcincta    trichostrongyles    genomic    nematode    crops    infections    route    direct    thorough    broad    mutants    levamisole    model    active    limit    alleles    class    strategies    treatment    first    primary    suggesting    laboratory    parasitic    amphidial    worldwide    unexplored    resistance    mechanisms    impeding    threatening    sensory    tools   

Project "IDRAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

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The information about "IDRAM" are provided by the European Opendata Portal: CORDIS opendata.

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