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IDRAM TERMINATED

The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDRAM project word cloud

Explore the words cloud of the IDRAM project. It provides you a very rough idea of what is the project "IDRAM" about.

food    route    phenotype    responsible    direct    teladorsagia    worldwide    commonplace    imidazothiazole    generate    contribution    circumcincta    resistance    anthelmintic    elegans    broad    supplies    impeding    amphids    lactone    public    significance    veterinary    defects    biochemical    treatment    link    model    tools    suggesting    mutants    exact    efficient    thorough    classes    unexplored    function    molecular    apparently    emergence    source    macrocyclic    amphidial    laboratory    parasitic    haemonchus    pave    infections    spectrum    poorly    amphid    genomic    drugs    difficult    heatlh    trichostrongyles    isolates    alleles    anthelmintics    strategies    benzimidazole    mutations    contortus    compounds    crops    active    threatening    hypothesize    albendazole    man    mechanism    nematode    nematodes    levamisole    first    sensory    drug    primary    sensitive    limit    livestock    techniques    lactones    understand    fast    class    resistant    cornerstone    mechanisms    health    organs    ivermectin   

Project "IDRAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

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The information about "IDRAM" are provided by the European Opendata Portal: CORDIS opendata.

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