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IDRAM TERMINATED

The role of amphidial drug uptake in the mode of action and resistance to ivermectin in nematodes of livestock

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 IDRAM project word cloud

Explore the words cloud of the IDRAM project. It provides you a very rough idea of what is the project "IDRAM" about.

mechanism    route    limit    primary    trichostrongyles    haemonchus    impeding    mutations    circumcincta    nematode    worldwide    infections    sensory    cornerstone    anthelmintics    first    sensitive    mechanisms    amphid    suggesting    supplies    apparently    livestock    isolates    nematodes    difficult    contribution    thorough    function    generate    laboratory    defects    strategies    drug    techniques    drugs    organs    ivermectin    benzimidazole    treatment    efficient    genomic    health    exact    link    commonplace    albendazole    crops    resistance    emergence    source    spectrum    amphids    imidazothiazole    anthelmintic    direct    responsible    poorly    active    alleles    contortus    phenotype    levamisole    broad    molecular    parasitic    man    food    class    biochemical    lactone    classes    elegans    veterinary    heatlh    teladorsagia    unexplored    model    threatening    public    tools    compounds    mutants    pave    fast    significance    understand    amphidial    hypothesize    macrocyclic    resistant    lactones   

Project "IDRAM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 195˙454.00

Map

 Project objective

The macrocyclic lactones such as ivermectin are the cornerstone for the treatment of key nematode infections of livestock, crops and man. Resistance to many of these broad-spectrum anthelmintics is becoming commonplace, while new classes of active compounds are increasingly difficult to find, threatening food supplies and public heatlh worldwide. The exact molecular and biochemical mechanisms of resistance, particularly to the widely used macrocyclic lactone class, are still poorly understood, impeding the development of efficient strategies to control drug resistance. I hypothesize that the amphidial sensory organs of nematodes are the major route of macrocyclic lactone drug uptake and that mutations in this uptake mechanism represents the primary source of drug resistance. In the first phase of the project, I will develop laboratory methods for testing amphid function in two parasitic nematodes of veterinary significance, the trichostrongyles Haemonchus contortus and Teladorsagia circumcincta. These techniques will be applied on drug resistant and sensitive isolates to evaluate the role of amphids in ivermectin uptake. In the second phase, I will use the C. elegans model to generate mutants resistant to three major classes of anthelmintic drugs, ivermectin, the benzimidazole albendazole and the imidazothiazole levamisole. I will then apply genomic tools to identify alleles responsible of this multi-drug resistance phenotype. This project aims to understand the link between amphid defects, anthelmintic drug uptake, and development of resistance, and will generate a thorough knowledge of this unexplored and apparently widespread resistance mechanism in nematodes. These results will also pave the way to the implementation of a fast and reliable measurement of drug resistance in the field. On the whole, the project will bring a direct contribution to current veterinary and public health challenges by suggesting new strategies to limit the emergence of drug resistance.

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The information about "IDRAM" are provided by the European Opendata Portal: CORDIS opendata.

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