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ESCRT model SIGNED

A biophysical model for ESCRT-III mediated membrane scission

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ESCRT model" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://science.curie.fr/members/nicola-de-franceschi/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

My project focuses on the characterization of the mechanism of action of ESCRT-III complex. ESCRTs are evolutionary conserved proteins which mediate membrane remodeling and scission in a variety of important cellular processes, and are implicated in the pathogenesis of many diseases, including virus release and nuclear membrane repair during cancer cell migration. Despite intense research, many outstanding questions still remain unanswered, and all model proposed remain highly speculative. Based on our preliminary data, we propose a novel, unifying model for ESCRT-III function. The aim of the project is to provide solid data to support this model by an in vitro reconstitution approach, which would constitute a major contribution in the field. The concrete aims of my project are:

- Characterization of the minimal ESCRT-III fission machinery - Characterization of the molecular mechanism leading to membrane fission by ESCRT-III complex - Characterization of the membrane requirements to obtain fission by ESCRT-III, in particular membrane curvature

 Publications

year authors and title journal last update
List of publications.
2018 De Franceschi Nicola, Alqabandi Maryam, Miguet Nolwenn, Caillat Christophe, Mangenot Stephanie, Weissenhorn Winfried, Bassereau Patricia.
The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks
published pages: , ISSN: 0021-9533, DOI:
Journal of Cell Science 2019-03-11

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