Explore the words cloud of the ESCRT model project. It provides you a very rough idea of what is the project "ESCRT model" about.
The following table provides information about the project.
|Coordinator Country||France [FR]|
|Total cost||185˙076 €|
|EC max contribution||185˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-04-01 to 2019-03-31|
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My project focuses on the characterization of the mechanism of action of ESCRT-III complex. ESCRTs are evolutionary conserved proteins which mediate membrane remodeling and scission in a variety of important cellular processes, and are implicated in the pathogenesis of many diseases, including virus release and nuclear membrane repair during cancer cell migration. Despite intense research, many outstanding questions still remain unanswered, and all model proposed remain highly speculative. Based on our preliminary data, we propose a novel, unifying model for ESCRT-III function. The aim of the project is to provide solid data to support this model by an in vitro reconstitution approach, which would constitute a major contribution in the field. The concrete aims of my project are:
- Characterization of the minimal ESCRT-III fission machinery - Characterization of the molecular mechanism leading to membrane fission by ESCRT-III complex - Characterization of the membrane requirements to obtain fission by ESCRT-III, in particular membrane curvature
|year||authors and title||journal||last update|
De Franceschi Nicola, Alqabandi Maryam, Miguet Nolwenn, Caillat Christophe, Mangenot Stephanie, Weissenhorn Winfried, Bassereau Patricia.
The ESCRT protein CHMP2B acts as a diffusion barrier on reconstituted membrane necks
published pages: , ISSN: 0021-9533, DOI:
|Journal of Cell Science||2019-03-11|
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The information about "ESCRT MODEL" are provided by the European Opendata Portal: CORDIS opendata.
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