Opendata, web and dolomites

RHEA SIGNED

Rotifers Highlight the Evolution of Asexuals: the mechanisms of genome evolution in the absence of meiosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RHEA project word cloud

Explore the words cloud of the RHEA project. It provides you a very rough idea of what is the project "RHEA" about.

recombination    strand    erc    group    components    gain    complementation    asexuality    population    never    rad    contact    sequencing    theoretical    predominant    computational    taxonomic    adineta    sex    simulation    vaga    taxa    genome    ago    rotifer    genetic    diverged    meiosis    notorious    negative    interesting    molecular    deterioration    uncover    ameiotic    adaptive    reproduce    evolution    time    revolutionize    asexuals    prolonged    suggest    perform    genomic    sequence    meiotic    model    prevent    cellular    ancient    genomics    arose    double    resistance    why    insights    lifestyle    confirming    bdelloid    dna    appear    spo11    asexual    generate    sister    rank    fundamental    desiccation    function    gene    bdelloids    asexually    genomes    biological    experiments    predictions    repair    persist    metazoans    reproduction    rotifers    published    first    sexual    positive    unclear    overwhelmingly    despite    clades    breaks    mutagenesis    mechanisms    diversification    lineages    highest    plan    species    assays    absence   

Project "RHEA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE NAMUR ASBL 

Organization address
address: RUE DE BRUXELLES 61
city: NAMUR
postcode: 5000
website: www.unamur.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙908˙375 €
 EC max contribution 1˙908˙375 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE NAMUR ASBL BE (NAMUR) coordinator 1˙908˙375.00

Map

 Project objective

Why sexual reproduction is overwhelmingly predominant among the metazoans remains unclear. Ancient asexual taxa are interesting model systems to gain general insights into the adaptive values of sex. The most notorious and the highest taxonomic rank within the metazoans to reproduce asexually is the bdelloid rotifers. While studies suggest that most asexuals arose recently, the published genome of the bdelloid rotifer Adineta vaga provided the first positive evidence for the long-term ameiotic evolution of this group, confirming its ancient asexuality. How bdelloid rotifers have been able to persist despite the expected negative consequences of asexuality is the focus of this ERC proposal. I will study the mechanisms that prevent genome deterioration and promote diversification in the absence of meiotic recombination. I will include sexual rotifer sister clades in the comparison and study all components of the bdelloid lifestyle that may foster their evolution. One of the key components could be their desiccation resistance and the associated DNA double-strand breaks that appear upon prolonged desiccation. To this end, I plan to (i) sequence genomes of sexual rotifers and distinct bdelloid species that diverged a long time ago, including lineages that never experience desiccation; (ii) apply contact genomics, cellular and molecular assays, as well as targeted mutagenesis to uncover their DNA repair mechanisms; (iii) use whole-genome and RAD sequencing to perform a population genomic study of genetic exchanges among bdelloids; and (iv) investigate the function of the meiosis-specific Spo11 gene in bdelloids through targeted mutagenesis and complementation experiments. Using a computational simulation I will generate theoretical predictions on the impact of the mechanisms promoting genome evolution in asexuals. This proposal should revolutionize the field of asexual evolution and provide a new biological model system to study fundamental processes such as DNA repair.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RHEA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RHEA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More