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NeurIMM

Neuroimmune activation as a novel therapeutic approach for IBD

Total Cost €

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EC-Contrib. €

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Partnership

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Project "NeurIMM" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 150˙000.00

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 Project objective

NeurIMM has been designed to investigate the commercial and technical viability of a novel, targeted therapy for Inflammatory Bowel Disease (IBD), based on a recently uncovered signaling axis between intestinal type 3 innate lymphoid cells (ILC3s) and enteric glial cells. This discovery by the team of Prof. Henrique Veiga-Fernandes in the ERC CoG grant 647274 ‘GliaInnateSensing’ was recently published in Nature (Ibiza et al, Nature 2016). NeurIMM proposes the use of a glial cell-derived immunomodulator to restore intestinal homeostasis, by inducing a tissue protective immune response. Importantly, this novel therapy will also promote tissue healing to reverse immune-cell mediated tissue damage, leading to improved outcomes for the patient. This could have major implications for patients suffering from IBD. In addition, this approach also has potential as an effective therapy against cancer, (pediatric) gastroenteritis, and other inflammatory disorders.

 Publications

year authors and title journal last update
List of publications.
2018 Johanna Emgård, Hana Kammoun, Bethania García-Cassani, Julie Chesné, Sara M. Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R. Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J. Villablanca, Henrique Veiga-Fernandes, João P. Pereira, Richard A. Flavell, Tim Willinger
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
published pages: 120-132.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.11.020
Immunity 48/1 2019-09-04
2018 Cristina Godinho-Silva, Filipa Cardoso, Henrique Veiga-Fernandes
Neuro–Immune Cell Units: A New Paradigm in Physiology
published pages: , ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042718-041812
Annual Review of Immunology 37/1 2019-09-04
2018 Roel G.J. Klein Wolterink, Roksana M. Pirzgalska, Henrique Veiga-Fernandes
Neuroendocrine Cells Take Your Breath Away
published pages: 9-11, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.06.010
Immunity 49/1 2019-09-04
2018 Henrique Veiga-Fernandes, David Artis
Neuronal–immune system cross-talk in homeostasis
published pages: 1465-1466, ISSN: 0036-8075, DOI: 10.1126/science.aap9598
Science 359/6383 2019-09-04
2019 Julie Chesné, Vânia Cardoso, Henrique Veiga-Fernandes
Neuro-immune regulation of mucosal physiology
published pages: 10-20, ISSN: 1933-0219, DOI: 10.1038/s41385-018-0063-y
Mucosal Immunology 12/1 2019-09-04

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