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Deconstructing Ageing: from molecular mechanisms to intervention strategies

Total Cost €


EC-Contrib. €






 DeAge project word cloud

Explore the words cloud of the DeAge project. It provides you a very rough idea of what is the project "DeAge" about.

accelerated    derives    discover    insights    normal    vivo    possibilities    explore    leverage    underlying    over    genome    cancer    accordingly    intervention    relationship    pathological    functional    allowed    autonomous    deficiency    mice    hallmarks    sequencing    clinical    multiple    lived    therapies    relative    explored    samples    extend    gilford    protected    reprogramming    integrative    strategies    extensive    exhibit    premature    protease    hypothesis    ageing    perform    multidisciplinary    syndrome    cell    integrate    expanding    critical    patients    relevance    fitness    first    laboratories    trials    hutchinson    metagenomic    experiments    mechanisms    genomic    human    central    organisms    mouse    unbiased    deficiencies    unveil    intrinsic    metabolic    extrinsic    molecular    generation    drive    models    editing    alterations    data    progeroid    combination    systemic    centenarians    progeria    syndromes    healthspan    group    longevity    understand   

Project "DeAge" data sheet

The following table provides information about the project.


Organization address
city: OVIEDO
postcode: 33003

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 2˙456˙250 €
 EC max contribution 2˙456˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE OVIEDO ES (OVIEDO) coordinator 2˙456˙250.00


 Project objective

Over many years, our research group has explored the complex relationship between cancer and ageing. As part of this work, we have generated mouse models of protease deficiency which are protected from cancer but exhibit accelerated ageing. Further studies with these mice have allowed us to unveil novel mechanisms of both normal and pathological ageing, to discover two new human progeroid syndromes, and to develop therapies for the Hutchinson-Gilford progeria syndrome, now in clinical trials. We have also integrated data from many laboratories to first define The hallmarks of ageing and the current possibilities for Metabolic control of longevity. Now, we propose to leverage our extensive experience in this field to further explore the relative relevance of cell-intrinsic and -extrinsic mechanisms of ageing. Our central hypothesis is that ageing derives from the combination of both systemic and cell-autonomous deficiencies which lead to the characteristic loss of fitness associated with this process. Accordingly, it is necessary to integrate multiple approaches to understand the mechanisms underlying ageing. This integrative and multidisciplinary project is organized around three major aims: 1) to characterize critical cell-intrinsic alterations which drive ageing; 2) to investigate ageing as a systemic process; and 3) to design intervention strategies aimed at expanding longevity. To fully address these objectives, we will use both hypothesis-driven and unbiased approaches, including next-generation sequencing, genome editing, and cell reprogramming. We will also perform in vivo experiments with mouse models of premature ageing, genomic and metagenomic studies with short- and long-lived organisms, and functional analyses with human samples from both progeria patients and centenarians. The information derived from this project will provide new insights into the molecular mechanisms of ageing and may lead to discover new opportunities to extend human healthspan.


year authors and title journal last update
List of publications.
2019 Clea Bárcena, Rafael Valdés-Mas, Pablo Mayoral, Cecilia Garabaya, Sylvère Durand, Francisco Rodríguez, María Teresa Fernández-García, Nuria Salazar, Alicja M. Nogacka, Nuria Garatachea, Noélie Bossut, Fanny Aprahamian, Alejandro Lucia, Guido Kroemer, José M. P. Freije, Pedro M. Quirós, Carlos López-Otín
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
published pages: 1234-1242, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0504-5
Nature Medicine 25/8 2020-03-24
2019 Magda R Hamczyk, Ricardo Villa‐Bellosta, Víctor Quesada, Pilar Gonzalo, Sandra Vidak, Rosa M Nevado, María J Andrés‐Manzano, Tom Misteli, Carlos López‐Otín, Vicente Andrés
Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells
published pages: , ISSN: 1757-4676, DOI: 10.15252/emmm.201809736
EMBO Molecular Medicine 11/4 2020-03-24
2018 Holly Whitton, Larry N. Singh, Marissa A. Patrick, Andrew J. Price, Fernando G. Osorio, Carlos López-Otín, Irina M. Bochkis
Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver
published pages: e12742, ISSN: 1474-9718, DOI: 10.1111/acel.12742
Aging Cell 17/3 2020-03-24
2018 Clea Bárcena, Carlos López-Otín, Guido Kroemer
Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?
published pages: 558-559, ISSN: 1554-8627, DOI: 10.1080/15548627.2018.1533059
Autophagy 15/3 2020-03-24
2019 Carlos Lopez-Otín, Guido Kroemer
Decelerating ageing and biological clocks by autophagy
published pages: 385-386, ISSN: 1471-0072, DOI: 10.1038/s41580-019-0149-8
Nature Reviews Molecular Cell Biology 20/7 2020-03-24
2019 Víctor Quesada, Sandra Freitas-Rodríguez, Joshua Miller, José G. Pérez-Silva, Zi-Feng Jiang, Washington Tapia, Olaya Santiago-Fernández, Diana Campos-Iglesias, Lukas F. K. Kuderna, Maud Quinzin, Miguel G. Álvarez, Dido Carrero, Luciano B. Beheregaray, James P. Gibbs, Ylenia Chiari, Scott Glaberman, Claudio Ciofi, Miguel Araujo-Voces, Pablo Mayoral, Javier R. Arango, Isaac Tamargo-Gómez, Dav
Giant tortoise genomes provide insights into longevity and age-related disease
published pages: 87-95, ISSN: 2397-334X, DOI: 10.1038/s41559-018-0733-x
Nature Ecology & Evolution 3/1 2020-03-24
2019 Dido Carrero, José G. Pérez-Silva, Víctor Quesada, Carlos López-Otín
Differential mechanisms of tolerance to extreme environmental conditions in tardigrades
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-51471-8
Scientific Reports 9/1 2020-03-24
2018 Guido Kroemer, Carlos López-Otín, Frank Madeo, Rafael de Cabo
Carbotoxicity—Noxious Effects of Carbohydrates
published pages: 605-614, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.07.044
Cell 175/3 2020-03-24
2019 Olaya Santiago-Fernández, Fernando G. Osorio, Víctor Quesada, Francisco Rodríguez, Sammy Basso, Daniel Maeso, Loïc Rolas, Anna Barkaway, Sussan Nourshargh, Alicia R. Folgueras, José M. P. Freije, Carlos López-Otín
Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome
published pages: 423-426, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0338-6
Nature Medicine 25/3 2020-03-24
2017 Xurde M. Caravia, David Roiz-Valle, Alba Morán-Álvarez, Carlos López-Otín
Functional relevance of miRNAs in premature ageing
published pages: 10-19, ISSN: 0047-6374, DOI: 10.1016/j.mad.2017.05.003
Mechanisms of Ageing and Development 168 2020-03-24
2017 Adolfo A Ferrando, Carlos López-Otín
Clonal evolution in leukemia
published pages: 1135-1145, ISSN: 1078-8956, DOI: 10.1038/nm.4410
Nature Medicine 23/10 2020-03-24
2019 Sundararajan Venkatesh, Min Li, Toshiro Saito, Mingming Tong, Eman Rashed, Satvik Mareedu, Peiyong Zhai, Clea Bárcena, Carlos López-Otín, Ghassan Yehia, Junichi Sadoshima, Carolyn K. Suzuki
Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo
published pages: 38-50, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2018.12.017
Journal of Molecular and Cellular Cardiology 128 2020-03-05
2018 Xurde M. Caravia, Víctor Fanjul, Eduardo Oliver, David Roiz-Valle, Alba Morán-Álvarez, Gabriela Desdín-Micó, María Mittelbrunn, Roberto Cabo, José A. Vega, Francisco Rodríguez, Antonio Fueyo, Mónica Gómez, Manuel Lobo-González, Héctor Bueno, Gloria Velasco, José M. P. Freije, Vicente Andrés, Borja Ibáñez, Alejandro P. Ugalde, Carlos López-Otín
The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function
published pages: e2006247, ISSN: 1544-9173, DOI: 10.1371/journal.pbio.2006247
PLOS Biology 16/10 2020-03-05
2017 Sandra Freitas-Rodríguez, Alicia R. Folgueras, Carlos López-Otín
The role of matrix metalloproteinases in aging: Tissue remodeling and beyond
published pages: 2015-2025, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2017.05.007
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864/11 2020-03-05
2017 Wesley C Warren, Lukas Kuderna, Alana Alexander, Julian Catchen, José G Pérez-Silva, Carlos López-Otín, Víctor Quesada, Patrick Minx, Chad Tomlinson, Michael J Montague, Fabiana H G Farias, Ronald B Walter, Tomas Marques-Bonet, Travis Glenn, Troy J Kieran, Sandra S Wise, John Pierce Wise, Robert M Waterhouse, John Pierce Wise
The Novel Evolution of the Sperm Whale Genome
published pages: 3260-3264, ISSN: 1759-6653, DOI: 10.1093/gbe/evx187
Genome Biology and Evolution 9/12 2020-02-28
2018 Alicia R. Folgueras, Sandra Freitas-Rodríguez, Gloria Velasco, Carlos López-Otín
Mouse Models to Disentangle the Hallmarks of Human Aging
published pages: 905-924, ISSN: 0009-7330, DOI: 10.1161/circresaha.118.312204
Circulation Research 123/7 2019-06-06
2018 Clea Bárcena, Pedro M. Quirós, Sylvère Durand, Pablo Mayoral, Francisco Rodríguez, Xurde M. Caravia, Guillermo Mariño, Cecilia Garabaya, María Teresa Fernández-García, Guido Kroemer, José M.P. Freije, Carlos López-Otín
Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism
published pages: 2392-2403, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.07.089
Cell Reports 24/9 2019-06-06

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