Explore the words cloud of the INDEX project. It provides you a very rough idea of what is the project "INDEX" about.
The following table provides information about the project.
CONSIGLIO NAZIONALE DELLE RICERCHE
|Coordinator Country||Italy [IT]|
|Total cost||2˙983˙525 €|
|EC max contribution||2˙982˙275 € (100%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2017-10-01 to 2020-09-30|
Take a look of project's partnership.
|1||CONSIGLIO NAZIONALE DELLE RICERCHE||IT (ROMA)||coordinator||758˙750.00|
|2||THE TRUSTEES OF BOSTON UNIVERSITY||US (BOSTON MA)||participant||708˙500.00|
|3||INSTITUT CURIE||FR (PARIS)||participant||516˙162.00|
|4||FLUIGENT SA||FR (LE KREMLIN-BICETRE)||participant||473˙862.00|
|5||REGION NORDJYLLAND (NORTH DENMARK REGION)||DK (AALBORG)||participant||310˙000.00|
|6||HANSABIOMED LIFE SCIENCES OU||EE (TALLINN)||participant||215˙000.00|
The aim of Project INDEX is to isolate and characterize nanoparticles available in bodily fluids through development and integration of novel technological breakthroughs. The technology will enable the analysis of clinically valuable nanoparticles called exosomes towards new generation diagnostics. Exosomes are known to mediate communication between cells and their effective utilization holds a great promise of revolutionizing the standard of clinical care. However, their detection and molecular profiling is technically challenging. The proposed technology will isolate exosomes that are as small as 30nm in diameter from human plasma with high purity, and provide in-depth, multi-parameter characterization of the particles through digital counting, size determination, and biological phenotyping. Towards this goal: (1) Novel microfluidics will be developed and used for efficient magnetic enrichment; (2) Isolated particles will be detected and analyzed with a novel biological nanoparticle (BNP) sensor (3) Immune-capture and release chemistries as well as phenotyping assays will be developed; (4) Critically, complete on-chip integration of isolation, detection and analysis will be accomplished; (5) Utility of in-depth exosome characterization will be demonstrated with clinical samples for lung cancer. Project INDEX requires successful integration of multiple sub-units and assays that each represents technological frontiers, which is extremely challenging. However, the breadth of information on exosomes that will be available with the integrated system is unmatched. Although, the clinical utility of exosomes is still developing, the uncertainty can only be clarified through automated technologies that provide latitude of information. Once completed, Project INDEX can demonstrate a new paradigm in cancer diagnostics, and also present a potential future technology for other applications involving nanoparticles.
|Data management plan||Open Research Data Pilot||2020-04-09 11:31:55|
|Report on exosome-specific Ab selection||Documents, reports||2020-04-09 11:31:55|
|Report on criteria for system demonstration||Documents, reports||2020-04-09 11:31:55|
|Project dedicated web site||Websites, patent fillings, videos etc.||2020-04-09 11:31:55|
Take a look to the deliverables list in detail: detailed list of INDEX deliverables.
|year||authors and title||journal||last update|
Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; ÃœnlÃ¼, M. Selim; et al.
Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging.
published pages: , ISSN: , DOI: 10.26434/chemrxiv.8976347.v1
Gori, Alessandro; Romanato, Alessandro; Bergamaschi, Greta; Strada, Alessandro; Gagni, Paola; Frigerio, Roberto; et al.
Membrane-Binding Peptides for Extracellular Vesicles On-Chip Analysis
published pages: , ISSN: , DOI: 10.26434/chemrxiv.9885167.v1
Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari
Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients
published pages: e0207876, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0207876
|PLOS ONE 13/12||2020-04-09|
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The information about "INDEX" are provided by the European Opendata Portal: CORDIS opendata.