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INDEX SIGNED

Integrated nanoparticle isolation and detection system for complete on-chip analysis of exosomes

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INDEX" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.indexproject.eu/
 Total cost 2˙983˙525 €
 EC max contribution 2˙982˙275 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 758˙750.00
2    THE TRUSTEES OF BOSTON UNIVERSITY US (BOSTON MA) participant 708˙500.00
3    INSTITUT CURIE FR (PARIS) participant 516˙162.00
4    FLUIGENT SA FR (LE KREMLIN-BICETRE) participant 473˙862.00
5    REGION NORDJYLLAND (NORTH DENMARK REGION) DK (AALBORG) participant 310˙000.00
6    HANSABIOMED LIFE SCIENCES OU EE (TALLINN) participant 215˙000.00

Map

 Project objective

The aim of Project INDEX is to isolate and characterize nanoparticles available in bodily fluids through development and integration of novel technological breakthroughs. The technology will enable the analysis of clinically valuable nanoparticles called exosomes towards new generation diagnostics. Exosomes are known to mediate communication between cells and their effective utilization holds a great promise of revolutionizing the standard of clinical care. However, their detection and molecular profiling is technically challenging. The proposed technology will isolate exosomes that are as small as 30nm in diameter from human plasma with high purity, and provide in-depth, multi-parameter characterization of the particles through digital counting, size determination, and biological phenotyping. Towards this goal: (1) Novel microfluidics will be developed and used for efficient magnetic enrichment; (2) Isolated particles will be detected and analyzed with a novel biological nanoparticle (BNP) sensor (3) Immune-capture and release chemistries as well as phenotyping assays will be developed; (4) Critically, complete on-chip integration of isolation, detection and analysis will be accomplished; (5) Utility of in-depth exosome characterization will be demonstrated with clinical samples for lung cancer. Project INDEX requires successful integration of multiple sub-units and assays that each represents technological frontiers, which is extremely challenging. However, the breadth of information on exosomes that will be available with the integrated system is unmatched. Although, the clinical utility of exosomes is still developing, the uncertainty can only be clarified through automated technologies that provide latitude of information. Once completed, Project INDEX can demonstrate a new paradigm in cancer diagnostics, and also present a potential future technology for other applications involving nanoparticles.

 Deliverables

List of deliverables.
Data management plan Open Research Data Pilot 2020-04-09 11:31:55
Report on exosome-specific Ab selection Documents, reports 2020-04-09 11:31:55
Report on criteria for system demonstration Documents, reports 2020-04-09 11:31:55
Project dedicated web site Websites, patent fillings, videos etc. 2020-04-09 11:31:55

Take a look to the deliverables list in detail:  detailed list of INDEX deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Chiodi, Elisa; Sola, Laura; Brambilla, Dario; Cretich, Marina; Marn, Allison; Ünlü, M. Selim; et al.
Simultaneous Evaluation of Multiple Microarray Surface Chemistries Through Real-Time Interferometric Imaging.
published pages: , ISSN: , DOI: 10.26434/chemrxiv.8976347.v1
Chemrxiv 2020-04-09
2019 Gori, Alessandro; Romanato, Alessandro; Bergamaschi, Greta; Strada, Alessandro; Gagni, Paola; Frigerio, Roberto; et al.
Membrane-Binding Peptides for Extracellular Vesicles On-Chip Analysis
published pages: , ISSN: , DOI: 10.26434/chemrxiv.9885167.v1
Chmrxiv 2020-04-09
2018 Francesco Damin, Silvia Galbiati, Nadia Soriani, Valentina Burgio, Monica Ronzoni, Maurizio Ferrari, Marcella Chiari
Analysis of KRAS, NRAS and BRAF mutational profile by combination of in-tube hybridization and universal tag-microarray in tumor tissue and plasma of colorectal cancer patients
published pages: e0207876, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0207876
PLOS ONE 13/12 2020-04-09

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The information about "INDEX" are provided by the European Opendata Portal: CORDIS opendata.

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