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RobustHormoneTrans SIGNED

Robustness and specialization among hormone transporters: Redundant and unique roles

Total Cost €

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EC-Contrib. €

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Partnership

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 RobustHormoneTrans project word cloud

Explore the words cloud of the RobustHormoneTrans project. It provides you a very rough idea of what is the project "RobustHormoneTrans" about.

diverse    ck    mechanisms    aba    organelle    function    disciplinary    assays    localized    vitro    designed    tightly    gradients    governed    robustness    arabidopsis    regulated    missing    tuned    levels    transportome    transporter    abc    hormones    candidate    signaling    finely    free    members    protein    genetic    screens    specificity    precise    specialized    limited    expertise    artificial    plant    broad    masked    genetics    ga    integrating    npf    gene    regulate    believe    tomato    emphasis    specialization    suggested    first    exporters    phenotypes    transport    regarding    of    auxin    respectively    genome    combined    experiments    tissue    profiling    hormone    families    redundant    subcellular    functions    impressive    bona    underlying    examine    reveal    transporters    redundancy    paradigms    populations    unveil    scarcity    plants    proteins    fide    localization    vivo    technological    progress    crispr    balance    places    shown    fundamental    made    family    mirnas   

Project "RobustHormoneTrans" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

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 Project objective

'Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise localization at the tissue and subcellular levels is still very limited. We and others have recently identified the first bona fide GA transporters in plants as members of the NPF protein family. Proteins from the ABC family were shown to transport the CK, ABA, and auxin hormones. Although these studies suggested specialized functions for members of these large protein families, progress in understanding their level of specialization has been limited by the scarcity of loss-of-function phenotypes, masked by the highly redundant plant genome. The goal of this proposal is to reveal the robust and specialized function of the NPF and ABC plant hormone transporter families. The project places key technological challenges that require multi-disciplinary expertise to examine how plants balance redundancy and specialization to tightly regulate hormone localization. Broad and targeted transportome screens using multi-targeted artificial miRNAs and CRISPR technology in Arabidopsis and tomato, respectively, are designed to unveil novel plant hormone transporters, with an emphasis on subcellular localized transporters and the missing GA exporters. Specialization and robustness of candidate transporters will be evaluated by integrating in vitro transport assays with in vivo growth and development experiments. I believe that the proposed 'redundant-free' populations will lead to new paradigms in plant genetics and would explain how gene families have developed robustness together with unique and diverse specialization. Importantly, our combined genetic and organelle-specific hormone profiling approaches will establish fundamental new concepts regarding plant hormone localization, activity, and specificity at the subcellular level.'

 Publications

year authors and title journal last update
List of publications.
2018 Gal Hyams, Shiran Abadi, Shlomtzion Lahav, Adi Avni, Eran Halperin, Eilon Shani, Itay Mayrose
CRISPys: Optimal sgRNA Design for Editing Multiple Members of a Gene Family Using the CRISPR System
published pages: 2184-2195, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.03.019
Journal of Molecular Biology 430/15 2019-08-05
2018 Jenia Binenbaum, Roy Weinstain, Eilon Shani
Gibberellin Localization and Transport in Plants
published pages: 410-421, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2018.02.005
Trends in Plant Science 23/5 2019-08-05
2018 Felix Hauser, Paulo H O Ceciliato, Yi-Chen Lin, DanDan Guo, J D Gregerson, Nazia Abbasi, Diana Youhanna, Jiyoung Park, Guillaume Dubeaux, Eilon Shani, Nusra Poomchongkho, Julian I Schroeder
A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/ery363
Journal of Experimental Botany 2019-08-05
2018 Yuqin Zhang, Victoria Nasser, Odelia Pisanty, Moutasem Omary, Nikolai Wulff, Martin Di Donato, Iris Tal, Felix Hauser, Pengchao Hao, Ohad Roth, Hillel Fromm, Julian I. Schroeder, Markus Geisler, Hussam Hassan Nour-Eldin, Eilon Shani
A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06410-y
Nature Communications 9/1 2019-08-05
2018 Ohad Roth, John P. Alvarez, Matan Levy, John L. Bowman, Naomi Ori, Eilon Shani
The KNOXI Transcription Factor SHOOT MERISTEMLESS Regulates Floral Fate in Arabidopsis
published pages: 1309-1321, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00222
The Plant Cell 30/6 2019-08-06

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