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RobustHormoneTrans SIGNED

Robustness and specialization among hormone transporters: Redundant and unique roles

Total Cost €


EC-Contrib. €






 RobustHormoneTrans project word cloud

Explore the words cloud of the RobustHormoneTrans project. It provides you a very rough idea of what is the project "RobustHormoneTrans" about.

balance    precise    specificity    transportome    emphasis    integrating    first    impressive    organelle    regulate    of    arabidopsis    regarding    vitro    examine    transporter    limited    specialized    designed    reveal    proteins    abc    places    scarcity    diverse    unveil    masked    paradigms    ck    plant    made    disciplinary    genome    expertise    tuned    gene    finely    redundant    mechanisms    governed    fundamental    hormones    subcellular    regulated    levels    families    transporters    tomato    npf    plants    exporters    localized    broad    free    shown    profiling    tightly    signaling    bona    screens    missing    vivo    mirnas    members    localization    crispr    genetic    fide    redundancy    believe    gradients    robustness    combined    aba    function    suggested    genetics    phenotypes    family    candidate    artificial    assays    respectively    specialization    progress    transport    tissue    underlying    functions    technological    hormone    ga    protein    populations    auxin    experiments   

Project "RobustHormoneTrans" data sheet

The following table provides information about the project.


Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00


 Project objective

'Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise localization at the tissue and subcellular levels is still very limited. We and others have recently identified the first bona fide GA transporters in plants as members of the NPF protein family. Proteins from the ABC family were shown to transport the CK, ABA, and auxin hormones. Although these studies suggested specialized functions for members of these large protein families, progress in understanding their level of specialization has been limited by the scarcity of loss-of-function phenotypes, masked by the highly redundant plant genome. The goal of this proposal is to reveal the robust and specialized function of the NPF and ABC plant hormone transporter families. The project places key technological challenges that require multi-disciplinary expertise to examine how plants balance redundancy and specialization to tightly regulate hormone localization. Broad and targeted transportome screens using multi-targeted artificial miRNAs and CRISPR technology in Arabidopsis and tomato, respectively, are designed to unveil novel plant hormone transporters, with an emphasis on subcellular localized transporters and the missing GA exporters. Specialization and robustness of candidate transporters will be evaluated by integrating in vitro transport assays with in vivo growth and development experiments. I believe that the proposed 'redundant-free' populations will lead to new paradigms in plant genetics and would explain how gene families have developed robustness together with unique and diverse specialization. Importantly, our combined genetic and organelle-specific hormone profiling approaches will establish fundamental new concepts regarding plant hormone localization, activity, and specificity at the subcellular level.'


year authors and title journal last update
List of publications.
2018 Gal Hyams, Shiran Abadi, Shlomtzion Lahav, Adi Avni, Eran Halperin, Eilon Shani, Itay Mayrose
CRISPys: Optimal sgRNA Design for Editing Multiple Members of a Gene Family Using the CRISPR System
published pages: 2184-2195, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.03.019
Journal of Molecular Biology 430/15 2019-08-05
2018 Jenia Binenbaum, Roy Weinstain, Eilon Shani
Gibberellin Localization and Transport in Plants
published pages: 410-421, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2018.02.005
Trends in Plant Science 23/5 2019-08-05
2018 Felix Hauser, Paulo H O Ceciliato, Yi-Chen Lin, DanDan Guo, J D Gregerson, Nazia Abbasi, Diana Youhanna, Jiyoung Park, Guillaume Dubeaux, Eilon Shani, Nusra Poomchongkho, Julian I Schroeder
A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/ery363
Journal of Experimental Botany 2019-08-05
2018 Yuqin Zhang, Victoria Nasser, Odelia Pisanty, Moutasem Omary, Nikolai Wulff, Martin Di Donato, Iris Tal, Felix Hauser, Pengchao Hao, Ohad Roth, Hillel Fromm, Julian I. Schroeder, Markus Geisler, Hussam Hassan Nour-Eldin, Eilon Shani
A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06410-y
Nature Communications 9/1 2019-08-05
2018 Ohad Roth, John P. Alvarez, Matan Levy, John L. Bowman, Naomi Ori, Eilon Shani
The KNOXI Transcription Factor SHOOT MERISTEMLESS Regulates Floral Fate in Arabidopsis
published pages: 1309-1321, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00222
The Plant Cell 30/6 2019-08-06

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