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RobustHormoneTrans SIGNED

Robustness and specialization among hormone transporters: Redundant and unique roles

Total Cost €

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EC-Contrib. €

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Partnership

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 RobustHormoneTrans project word cloud

Explore the words cloud of the RobustHormoneTrans project. It provides you a very rough idea of what is the project "RobustHormoneTrans" about.

tuned    crispr    specificity    underlying    bona    believe    family    of    vitro    places    functions    candidate    tomato    phenotypes    screens    expertise    plants    limited    experiments    levels    designed    impressive    localized    scarcity    unveil    specialized    organelle    suggested    aba    shown    function    protein    signaling    hormones    robustness    proteins    respectively    transporters    arabidopsis    first    populations    abc    tightly    paradigms    tissue    exporters    progress    gene    hormone    reveal    examine    combined    transportome    transport    diverse    made    governed    assays    genetics    regulated    missing    mechanisms    transporter    vivo    families    genetic    precise    redundant    finely    genome    broad    gradients    profiling    ck    plant    fide    subcellular    integrating    technological    artificial    emphasis    mirnas    auxin    masked    fundamental    redundancy    free    localization    regarding    specialization    ga    regulate    balance    members    disciplinary    npf   

Project "RobustHormoneTrans" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 1˙500˙000.00

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 Project objective

'Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise localization at the tissue and subcellular levels is still very limited. We and others have recently identified the first bona fide GA transporters in plants as members of the NPF protein family. Proteins from the ABC family were shown to transport the CK, ABA, and auxin hormones. Although these studies suggested specialized functions for members of these large protein families, progress in understanding their level of specialization has been limited by the scarcity of loss-of-function phenotypes, masked by the highly redundant plant genome. The goal of this proposal is to reveal the robust and specialized function of the NPF and ABC plant hormone transporter families. The project places key technological challenges that require multi-disciplinary expertise to examine how plants balance redundancy and specialization to tightly regulate hormone localization. Broad and targeted transportome screens using multi-targeted artificial miRNAs and CRISPR technology in Arabidopsis and tomato, respectively, are designed to unveil novel plant hormone transporters, with an emphasis on subcellular localized transporters and the missing GA exporters. Specialization and robustness of candidate transporters will be evaluated by integrating in vitro transport assays with in vivo growth and development experiments. I believe that the proposed 'redundant-free' populations will lead to new paradigms in plant genetics and would explain how gene families have developed robustness together with unique and diverse specialization. Importantly, our combined genetic and organelle-specific hormone profiling approaches will establish fundamental new concepts regarding plant hormone localization, activity, and specificity at the subcellular level.'

 Publications

year authors and title journal last update
List of publications.
2018 Gal Hyams, Shiran Abadi, Shlomtzion Lahav, Adi Avni, Eran Halperin, Eilon Shani, Itay Mayrose
CRISPys: Optimal sgRNA Design for Editing Multiple Members of a Gene Family Using the CRISPR System
published pages: 2184-2195, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2018.03.019
Journal of Molecular Biology 430/15 2019-08-05
2018 Jenia Binenbaum, Roy Weinstain, Eilon Shani
Gibberellin Localization and Transport in Plants
published pages: 410-421, ISSN: 1360-1385, DOI: 10.1016/j.tplants.2018.02.005
Trends in Plant Science 23/5 2019-08-05
2018 Felix Hauser, Paulo H O Ceciliato, Yi-Chen Lin, DanDan Guo, J D Gregerson, Nazia Abbasi, Diana Youhanna, Jiyoung Park, Guillaume Dubeaux, Eilon Shani, Nusra Poomchongkho, Julian I Schroeder
A seed resource for screening functionally redundant genes and isolation of new mutants impaired in CO2 and ABA responses
published pages: , ISSN: 0022-0957, DOI: 10.1093/jxb/ery363
Journal of Experimental Botany 2019-08-05
2018 Yuqin Zhang, Victoria Nasser, Odelia Pisanty, Moutasem Omary, Nikolai Wulff, Martin Di Donato, Iris Tal, Felix Hauser, Pengchao Hao, Ohad Roth, Hillel Fromm, Julian I. Schroeder, Markus Geisler, Hussam Hassan Nour-Eldin, Eilon Shani
A transportome-scale amiRNA-based screen identifies redundant roles of Arabidopsis ABCB6 and ABCB20 in auxin transport
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06410-y
Nature Communications 9/1 2019-08-05
2018 Ohad Roth, John P. Alvarez, Matan Levy, John L. Bowman, Naomi Ori, Eilon Shani
The KNOXI Transcription Factor SHOOT MERISTEMLESS Regulates Floral Fate in Arabidopsis
published pages: 1309-1321, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00222
The Plant Cell 30/6 2019-08-06

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