Opendata, web and dolomites

RESUSCITATION

Bacterial persister regrowth

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RESUSCITATION project word cloud

Explore the words cloud of the RESUSCITATION project. It provides you a very rough idea of what is the project "RESUSCITATION" about.

regrowth    biology    exit    mechanisms    extend    intoxication    offspring    pressure    repertoire    detoxifying    discovery    vs    question    persistence    arrest    unknown    ultimately    lag    characterization    multidrug    bacteria    balance    detoxification    experimental    sensitized    counteracting    tolerant    enzyme    proportions    plan    couple    infectious    identification    generate    unravel    pth    resuscitation    persist    cells    tact    forming    underlying    powerful    implication    progress    resumption    toxins    force    resuming    transiently    removed    defence    first    intend    group    persister    entry    toxin    action    engulfment    dissect    antibiotic    host    consolidation    inducing    encounter    relapses    interaction    begin    systematic    model    pending    antitoxin    modules    form    re    environment    salmonella    14    enzymes    antibiotics    additionally    persisters    diseases    activates    despite    proven    ways    respectively    macrophages   

Project "RESUSCITATION" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙996 €
 EC max contribution 1˙499˙996 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 1˙499˙996.00

Map

 Project objective

This proposal aims to provide insight into persister resuscitation. Persisters are multidrug-tolerant cells that are transiently non-growing and able to generate viable offspring by resuming growth when antibiotic pressure is removed. Despite their implication in relapses of many infectious diseases, and progress in understanding how persisters form through the action of toxin-antitoxin modules, the mechanisms underlying resuscitation of these persisters are still unknown. The interaction between Salmonella and host macrophages has proven to be a powerful and relevant model to study persister biology since the bacteria specifically respond to engulfment by the host defence cells by forming high proportions of persisters. Upon encounter with the host, Salmonella activates 14 toxins to arrest growth and persist in this environment. With the recent discovery of a detoxifying enzyme (Pth) counteracting the action of a persister-inducing toxin (TacT), thus allowing growth resumption of Salmonella persisters, we can now begin to address the pending question of persister regrowth. The consolidation of my research group around the experimental plan proposed here, will enable us to dissect the balance between intoxication vs. detoxification or entry vs. exit from persistence induced by Tact and Pth respectively. This is the first couple of toxin/detoxifying enzymes to be identified. I intend to extend this knowledge to the whole repertoire of toxins involved in Salmonella persister formation through systematic identification and characterization of the detoxifying mechanisms allowing resuscitation. Additionally I will investigate the lag phase leading to regrowth of persisters; and target the toxins involved in persister formation to force persisters out of growth arrest. This work will unravel persister resuscitation and could ultimately provide ways to force persisters out of that state so they become re-sensitized to antibiotics.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RESUSCITATION" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "RESUSCITATION" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

PonD (2019)

Particles-on-Demand for Multiscale Fluid Dynamics

Read More  

MITOvTOXO (2020)

Understanding how mitochondria compete with Toxoplasma for nutrients to defend the host cell

Read More