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PROMETHEUS SIGNED

Flame nanoengineering for antibacterial medical devices

Total Cost €

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EC-Contrib. €

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Partnership

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 PROMETHEUS project word cloud

Explore the words cloud of the PROMETHEUS project. It provides you a very rough idea of what is the project "PROMETHEUS" about.

integration    nanocoatings    human    medical    osteogenic    nanotechnology    understudied    health    powders    microneedle    patch    discoveries    worldwide    quite    poor    skin    synthesis    direct    smart    physicochemical    limitations    fight    implants    engineering    self    estimations    aerosol    commodity    combining    resistant    medicine    hybrid    threat    famous    maintained    antibiotic    antimicrobial    bacteria    commercialization    photothermal    threatening    nanoparticle    triggered    reproducibility    layer    principles    last    too    deaths    resistance    reactors    translated    life    serious    nanomanufacture    innovative    assist    materials    little    antibacterial    infections    successful    labs    engineers    constitutes    few    hr    commercial    designing    basic    flame    device    generation    drug    functional    inherent    assembly    substrates    hinders    outcome    decade    utilize    scalability    tons    public    nanoparticles    deposition    close    nanoscale    single   

Project "PROMETHEUS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙812˙500 €
 EC max contribution 1˙812˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 1˙812˙500.00

Map

 Project objective

Engineers in nanotechnology research labs have been quite innovative the last decade in designing nanoscale materials for medicine. However, very few of these exciting discoveries are translated to commercial medical products today. The main reasons for this are two inherent limitations of most nanomanufacture processes: scalability and reproducibility. There is too little knowledge on how well the unique properties associated with nanoparticles are maintained during their large-scale production while often poor reproducibility hinders their successful use. A key goal here is to utilize a nanomanufacture process famous for its scalability and reproducibility, flame aerosol reactors that produce at tons/hr commodity powders, and advance the knowledge for synthesis of complex nanoparticles and their direct integration in medical devices. Our aim is to develop the next generation of antibacterial medical devices to fight antimicrobial resistance, a highly understudied field. Antimicrobial resistance constitutes the most serious public health threat today with estimations to become the leading cause of human deaths in 30 years. We focus on flame direct nanoparticle deposition on substrates combining nanoparticle production and functional layer deposition in a single-step with close attention to product nanoparticle properties and device assembly, extending beyond the simple commodity powders of the past. Specific targets here are two devices; a) hybrid drug microneedle patch with photothermal nanoparticles to fight life-threatening skin infections from drug-resistant bacteria and b) smart nanocoatings on implants providing both osteogenic and self-triggered antibacterial properties. The engineering approach for the development of antibacterial devices will provide insight into the basic physicochemical principles to assist in commercialization while the outcome of this research will help the fight against antibiotic resistance improving the public health worldwide.

 Publications

year authors and title journal last update
List of publications.
2019 Dorian F. Henning, Padryk Merkl, Changhun Yun, Federico Iovino, Ling Xie, Eleftherios Mouzourakis, Constantinos Moularas, Yiannis Deligiannakis, Birgitta Henriques-Normark, Klaus Leifer, Georgios A. Sotiriou
Luminescent CeO2:Eu3+ nanocrystals for robust in situ H2O2 real-time detection in bacterial cell cultures
published pages: 286-293, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.03.012
Biosensors and Bioelectronics 132 2019-11-22

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The information about "PROMETHEUS" are provided by the European Opendata Portal: CORDIS opendata.

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