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PROMETHEUS SIGNED

Flame nanoengineering for antibacterial medical devices

Total Cost €

EC-Contrib. €

Partnership

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PROMETHEUS project word cloud

Explore the words cloud of the PROMETHEUS project. It provides you a very rough idea of what is the project "PROMETHEUS" about.

maintained last estimations engineering nanocoatings generation threatening nanoscale hr commercialization labs utilize materials microneedle antibacterial little worldwide assist poor infections few nanoparticle commercial antimicrobial assembly hinders direct functional implants osteogenic outcome basic powders fight drug nanoparticles device quite smart threat engineers reactors aerosol single flame bacteria tons resistance successful close scalability too life limitations hybrid combining synthesis understudied serious decade skin innovative medicine layer self nanotechnology reproducibility principles integration health substrates translated physicochemical discoveries deposition antibiotic medical designing constitutes resistant human deaths nanomanufacture public triggered patch inherent commodity famous photothermal

Project "PROMETHEUS" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	1˙812˙500 €
EC max contribution	1˙812˙500 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙812˙500.00

Map

Project objective

Engineers in nanotechnology research labs have been quite innovative the last decade in designing nanoscale materials for medicine. However, very few of these exciting discoveries are translated to commercial medical products today. The main reasons for this are two inherent limitations of most nanomanufacture processes: scalability and reproducibility. There is too little knowledge on how well the unique properties associated with nanoparticles are maintained during their large-scale production while often poor reproducibility hinders their successful use. A key goal here is to utilize a nanomanufacture process famous for its scalability and reproducibility, flame aerosol reactors that produce at tons/hr commodity powders, and advance the knowledge for synthesis of complex nanoparticles and their direct integration in medical devices. Our aim is to develop the next generation of antibacterial medical devices to fight antimicrobial resistance, a highly understudied field. Antimicrobial resistance constitutes the most serious public health threat today with estimations to become the leading cause of human deaths in 30 years. We focus on flame direct nanoparticle deposition on substrates combining nanoparticle production and functional layer deposition in a single-step with close attention to product nanoparticle properties and device assembly, extending beyond the simple commodity powders of the past. Specific targets here are two devices; a) hybrid drug microneedle patch with photothermal nanoparticles to fight life-threatening skin infections from drug-resistant bacteria and b) smart nanocoatings on implants providing both osteogenic and self-triggered antibacterial properties. The engineering approach for the development of antibacterial devices will provide insight into the basic physicochemical principles to assist in commercialization while the outcome of this research will help the fight against antibiotic resistance improving the public health worldwide.

Publications

List of publications.
year	authors and title	journal	last update
2019	Dorian F. Henning, Padryk Merkl, Changhun Yun, Federico Iovino, Ling Xie, Eleftherios Mouzourakis, Constantinos Moularas, Yiannis Deligiannakis, Birgitta Henriques-Normark, Klaus Leifer, Georgios A. Sotiriou Luminescent CeO2:Eu3+ nanocrystals for robust in situ H2O2 real-time detection in bacterial cell cultures published pages: 286-293, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.03.012	Biosensors and Bioelectronics 132	2019-11-22

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