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SUGARCODING SIGNED

The neuroenergetics of memory consolidation – hybrid PET/MR imaging of the default mode network

Total Cost €

EC-Contrib. €

Partnership

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SUGARCODING project word cloud

Explore the words cloud of the SUGARCODING project. It provides you a very rough idea of what is the project "SUGARCODING" about.

simultaneously emission complementary directed neuronal behavior option function magnetic invasive engage baseline disease hybrid default hypothesis retrieval universal paradox uncovering revealed functional consolidation consumes directional alzheimer pathological unknown demand plasticity deviations ago cognitive connectivity modulate metabolism brain seems deactivates energy anxiety first interrupted massively metabolic reported therapeutic resonance memories signaling once imaging orchestrate resemble sugarcoding episodic mainly human consolidated since active positron stimulation memory mode resting hypothesize glucose encoding deactivations subjects track hundreds pet tomography mind disorders fmri affective decade disturbed dmn critically mr psychiatric synaptic network regions integrating discovery

Project "SUGARCODING" data sheet

The following table provides information about the project.

Coordinator	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	1˙499˙403 €
EC max contribution	1˙499˙403 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2023-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	1˙499˙403.00

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Project objective

Since its discovery more than a decade ago, the most studied network in the human brain remains a paradox. The default mode network (DMN) is most active during the resting state and deactivates once subjects engage in goal directed behavior. Although reported in hundreds of studies using functional magnetic resonance imaging (fMRI), the function of the DMN is still unknown. I hypothesize that memories are consolidated in the DMN during resting state, a process that is interrupted once we engage in cognitive processing. This hypothesis is based on two complementary and recent findings. First, brain regions involved in encoding of novel or retrieval of consolidated memories strongly resemble regions of the DMN. Second, the DMN consumes most glucose during resting state as revealed by positron emission tomography (PET). Importantly, energy in the brain is mainly dedicated to neuronal signaling and synaptic plasticity related to memory consolidation. To test my hypothesis, I will use hybrid PET/MR imaging to simultaneously study fMRI activity and energy metabolism of the DMN during episodic memory processing. Integrating this novel imaging approach with my recently developed brain connectivity methods, I will (i) identify the metabolic baseline of fMRI-deactivations in the DMN, (ii) track the metabolic demand and directional connectivity in the DMN during memory consolidation, and (iii) evaluate non-invasive brain stimulation as a therapeutic option to modulate memory consolidation. The DMN is massively disturbed in psychiatric disorders such as Alzheimer’s disease, anxiety and affective disorders. SUGARCODING aims at uncovering memory consolidation as a universal function of the DMN that seems to critically orchestrate the human mind and its pathological deviations. ...

Publications

List of publications.
year	authors and title	journal	last update
2020	Gabriel Castrillon, Nico Sollmann, Katarzyna Kurcyus, Adeel Razi, Sandro M. Krieg, Valentin Riedl The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex published pages: eaay2739, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay2739	Science Advances 6/5	2020-03-05

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