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SUGARCODING SIGNED

The neuroenergetics of memory consolidation – hybrid PET/MR imaging of the default mode network

Total Cost €

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EC-Contrib. €

0

Partnership

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 SUGARCODING project word cloud

Explore the words cloud of the SUGARCODING project. It provides you a very rough idea of what is the project "SUGARCODING" about.

connectivity    energy    alzheimer    hybrid    pet    critically    mainly    disease    resting    resonance    human    pathological    metabolism    memory    synaptic    invasive    stimulation    deactivations    discovery    episodic    consumes    engage    neuronal    hundreds    tomography    memories    revealed    reported    signaling    positron    unknown    retrieval    metabolic    decade    massively    subjects    affective    demand    universal    functional    cognitive    interrupted    complementary    brain    plasticity    psychiatric    disturbed    modulate    consolidation    emission    mind    ago    mr    resemble    first    once    regions    imaging    directional    encoding    disorders    hypothesis    uncovering    directed    track    therapeutic    fmri    since    magnetic    sugarcoding    integrating    anxiety    function    orchestrate    behavior    default    deactivates    network    seems    deviations    paradox    glucose    dmn    mode    active    simultaneously    option    baseline    hypothesize    consolidated   

Project "SUGARCODING" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN 

Organization address
address: ISMANINGER STRASSE 22
city: MUENCHEN
postcode: 81675
website: http://www.med.tu.muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙403 €
 EC max contribution 1˙499˙403 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE (MUENCHEN) coordinator 1˙499˙403.00

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 Project objective

Since its discovery more than a decade ago, the most studied network in the human brain remains a paradox. The default mode network (DMN) is most active during the resting state and deactivates once subjects engage in goal directed behavior. Although reported in hundreds of studies using functional magnetic resonance imaging (fMRI), the function of the DMN is still unknown. I hypothesize that memories are consolidated in the DMN during resting state, a process that is interrupted once we engage in cognitive processing. This hypothesis is based on two complementary and recent findings. First, brain regions involved in encoding of novel or retrieval of consolidated memories strongly resemble regions of the DMN. Second, the DMN consumes most glucose during resting state as revealed by positron emission tomography (PET). Importantly, energy in the brain is mainly dedicated to neuronal signaling and synaptic plasticity related to memory consolidation. To test my hypothesis, I will use hybrid PET/MR imaging to simultaneously study fMRI activity and energy metabolism of the DMN during episodic memory processing. Integrating this novel imaging approach with my recently developed brain connectivity methods, I will (i) identify the metabolic baseline of fMRI-deactivations in the DMN, (ii) track the metabolic demand and directional connectivity in the DMN during memory consolidation, and (iii) evaluate non-invasive brain stimulation as a therapeutic option to modulate memory consolidation. The DMN is massively disturbed in psychiatric disorders such as Alzheimer’s disease, anxiety and affective disorders. SUGARCODING aims at uncovering memory consolidation as a universal function of the DMN that seems to critically orchestrate the human mind and its pathological deviations. ...

 Publications

year authors and title journal last update
List of publications.
2020 Gabriel Castrillon, Nico Sollmann, Katarzyna Kurcyus, Adeel Razi, Sandro M. Krieg, Valentin Riedl
The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex
published pages: eaay2739, ISSN: 2375-2548, DOI: 10.1126/sciadv.aay2739
Science Advances 6/5 2020-03-05

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The information about "SUGARCODING" are provided by the European Opendata Portal: CORDIS opendata.

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