Opendata, web and dolomites

MTrix SIGNED

Mechanical Targeting as an Integrative Approach for Personalized Nanomedicine

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MTrix project word cloud

Explore the words cloud of the MTrix project. It provides you a very rough idea of what is the project "MTrix" about.

patient    failures    molecules    rationale    chemotherapies    specificity    exposure    basis    internalization    mt    yield    balance    models    physical    experimental    extremely    deformability    tuning    unlike    tests    effort    treating    therapeutic    tumors    engulf    enhanced    shape    flexibility    visionary    considering    dramatically    critical    light    oncology    off    poor    cues    accordingly    dynamic    heterogeneity    introduce    cancers    tuned    clinical    costly    dds    conceptual    personalized    tools    safety    leads    tissues    efficacy    determines    computational    performed    scheme    massive    causing    target    selectivity    metastatic    undesired    direct    stiffer    correlated    toxicity    mechanical    reducing    central    particles    erc    nature    systemic    issue    cells    pharmaceutical    drugs    cancer    hypothesis    breakthroughs    severe    substantially    global    diseases    selective    crosstalk    rational    drug    industry    normal    universal    nanomedicine    enormous   

Project "MTrix" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://www.benny-lab.com/research
 Total cost 1˙499˙875 €
 EC max contribution 1˙499˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 1˙499˙875.00

Map

 Project objective

The ability to direct drug delivery to specific tissues is a central challenge in treating diseases as it determines the balance between drug selectivity and toxicity. Clinical drug failures, commonly due to safety issues or poor efficacy, are extremely costly to the pharmaceutical industry. In light of this, there is a global effort to develop Targeted Drug Delivery Systems (DDS) and Nanomedicine-based drugs to increase the therapeutic efficacy of a drug while substantially reducing its off-target exposure. In oncology, this issue is critical since chemotherapies have poor selectivity, thus causing severe side effects due to undesired systemic exposure. However, the enormous heterogeneity and dynamic nature of tumors makes it extremely challenging to identify universal target molecules. In this ERC I introduce a novel concept according to which the specificity of DDS can be dramatically enhanced by tuning the physical parameters of DDS based on mechanical cues of target and non-target cells. In many cancers, it is well-established that the flexibility and deformability of cells are correlated with their metastatic potential. This leads to our hypothesis that the enhanced deformability of cancer cells allows them to engulf and uptake particles whose internalization requires massive shape change, unlike the stiffer and normal cells. The rationale of the proposed study is that by considering physical parameters of cells, the mechanical properties of DDS can be tuned to achieve selective uptake. We thus propose to develop tools for rational design of DDS for personalized nanomedicine that will use simple tests performed on a patient’s own cells. This is the basis of our visionary Mechanical Targeting (MT) scheme, a crosstalk between experimental and computational models, for drug specificity. Accordingly, this ERC is expected to yield breakthroughs, both conceptual and technical.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MTRIX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MTRIX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

CN Identity (2019)

Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks

Read More  

sociOlfa (2020)

Learning from social scents: from territory to identity

Read More