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Imaging NM: A Nanoparticulate Precision Medicine Approach to Target Cancer

Total Cost €


EC-Contrib. €






 INTACT project word cloud

Explore the words cloud of the INTACT project. It provides you a very rough idea of what is the project "INTACT" about.

perform    nanomedicines    insufficient    treatment    appropriate    worldwide    treat    bladder    2024    causes    pet    visualize    nanoparticles    exceeding    personalisation    neutropenia    medicine    therapeutic    profile    inappropriate    drugs    heterogeneity    market    options    biodistribution    ovarian    patient    launch    efficacy    boost    exposing    oncologists    receive    finalizing    business    avoids    exhibit    100m    performance    deal    selectively    revenues    therapeutics    intact    lab    projected    time    demonstrated    89zr    cripec    assures    drug    clinical    enhanced    develops    reg    docetaxel    truly    platform    ct    maximum    personalized    10fte    safety    validate    limited    preclinically    2022    adverse    death    deals    generate    site    close    gap    licensing    diseases    correlated    turns    whereby    trials    significantly    tracer    generation    decorated    patients    cancer    cristal    nanomedicine    superior    tumour    pharmacokinetic    alopecia    trial    gt   

Project "INTACT" data sheet

The following table provides information about the project.


Organization address
address: OXFORDLAAN 55
postcode: 6229 EV
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 8˙996˙610 €
 EC max contribution 2˙499˙999 € (28%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-2-2016-2017
 Funding Scheme SME-2
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CRISTAL DELIVERY BV NL (MAASTRICHT) coordinator 2˙499˙999.00


 Project objective

Cristal Therapeutics (CT) develops the next generation of nanomedicines to treat cancer. Cancer remains one the leading causes of death worldwide, and current treatment options are insufficient, in part due to the tumour heterogeneity between patients. CT has developed state-of-the-art nanoparticles (CriPec®) to target a drug of choice more selectively to the tumour site(s). The superior therapeutic performance of this approach has already been demonstrated preclinically for CT’ lead product CriPec® docetaxel and a promising clinical phase I trial is finalizing, providing a significantly increased pharmacokinetic and safety profile. CT already observed activity in patients and much reduced neutropenia and alopecia. In INTACT, CT will perform phase II clinical trials in ovarian and bladder cancer to evaluate the therapeutic efficacy of CriPec® docetaxel. Furthermore, CriPec® docetaxel will be decorated with a PET tracer (89Zr), which enables oncologists to visualize CriPec® biodistribution in real-time. Tumour uptake will be correlated with therapeutic responses and result in parameters for future patient selection. This approach turns the drug into a personalized medicine whereby only those patients that exhibit enhanced tumour-targeting will be treated. This personalisation assures maximum efficacy in selected patients, avoids exposing patients to inappropriate drugs and adverse effects, and allows patients with limited tumour targeting to receive other more appropriate treatment. CT will use INTACT to close the gap from lab to market and facilitate a licensing deal for CriPec® docetaxel, projected to generate revenues exceeding >€100M in 2024. More importantly, INTACT will validate the CriPec® nanomedicine platform, boost product development for other diseases through licensing deals, and provide a growth of 10FTE by 2022. Success in INTACT will truly launch Cristal Therapeutics’ business.

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The information about "INTACT" are provided by the European Opendata Portal: CORDIS opendata.

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