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MacroStability SIGNED

Stability and dynamics at different spatial scales: From physiology to Alzheimer's degeneration

Total Cost €

0

EC-Contrib. €

0

Partnership

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 MacroStability project word cloud

Explore the words cloud of the MacroStability project. It provides you a very rough idea of what is the project "MacroStability" about.

invariant    negative    intrinsically    molecular    disease    combine    monitoring    machinery    timescales    conceptual    diverse    underlying    photon    synapses    microscopy    function    disorders    fundamental    imaging    single    stabilize    neuroscience    neural    pathophysiology    excitation    ad    uncovered    resolved    context    empirical    questions    circuitry    patterns    neurodegenerative    phenotypes    principles    behaving    maintained    neuronal    signaling    populations    mice    aberrant    circuits    individual    point    basic    utilizing    regulation    unstable    longitudinal    stability    spatial    extended    environment    firing    constantly    relationships    neurons    spiking    memory    dynamics    alzheimer    ex    how    elucidate    integrative    feedback    first    extensive    decline    theoretical    scales    time    vivo    suggest    hippocampal    homeostatic    plasticity    brain    electrophysiology    overlapping    dependent    biology    rates    insights    fluorescence    compromised    failures    population    ongoing    mechanisms    changing    destabilization    meta    balance    operate   

Project "MacroStability" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙000˙000.00

Map

 Project objective

How neuronal circuits maintain the balance between stability and plasticity in a constantly changing environment remains one of the most fundamental questions in neuroscience. Empirical and theoretical studies suggest that homeostatic negative feedback mechanisms operate to stabilize the function of a system at a set point level of activity. While extensive research uncovered diverse homeostatic mechanisms that maintain activity of neural circuits at extended timescales, several key questions remain open. First, what are the basic principles and the molecular machinery underlying invariant population dynamics of neural circuits, composed from intrinsically unstable activity patterns of individual neurons? Second, is homeostatic regulation compromised in Alzheimer's disease (AD) and do homeostatic failures lead to aberrant brain activity and memory decline, the overlapping phenotypes of AD and many other distinct neurodegenerative disorders? And finally, how do homeostatic systems operate in vivo under experience-dependent changes in firing rates and patterns? To target these questions, we have developed an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations, signaling processes at the level of single synapses and neuronal meta-plasticity. We will focus on hippocampal circuitry and combine ex vivo electrophysiology, single- and two-photon excitation imaging, time-resolved fluorescence microscopy and molecular biology, together with longitudinal monitoring of activity from large populations of hippocampal neurons in freely behaving mice. Utilizing these state-of-the-art approaches, we will determine how firing stability is maintained at different spatial scales and what are the mechanisms leading to destabilization of firing patterns in AD-related context. The proposed research will elucidate fundamental principles of neuronal function and offer conceptual insights into AD pathophysiology.

 Publications

year authors and title journal last update
List of publications.
2018 Boaz Styr, Inna Slutsky
Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
published pages: 463-473, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0080-x
Nature Neuroscience 21/4 2019-06-06
2018 Samuel Frere, Inna Slutsky
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
published pages: 32-58, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.11.028
Neuron 97/1 2019-06-06
2019 Heather C. Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N. Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M. Ranaivoson, Davide Comoletti, Jeffrey N. Savas, Han Remaut, Detlef Balschun, Keimpe D. Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit
Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
published pages: eaao4827, ISSN: 0036-8075, DOI: 10.1126/science.aao4827
Science 363/6423 2019-06-06
2019 Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.03.045
Neuron 2019-06-06

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