Explore the words cloud of the MacroStability project. It provides you a very rough idea of what is the project "MacroStability" about.
The following table provides information about the project.
TEL AVIV UNIVERSITY
|Coordinator Country||Israel [IL]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-10-01 to 2022-09-30|
Take a look of project's partnership.
|1||TEL AVIV UNIVERSITY||IL (TEL AVIV)||coordinator||2˙000˙000.00|
How neuronal circuits maintain the balance between stability and plasticity in a constantly changing environment remains one of the most fundamental questions in neuroscience. Empirical and theoretical studies suggest that homeostatic negative feedback mechanisms operate to stabilize the function of a system at a set point level of activity. While extensive research uncovered diverse homeostatic mechanisms that maintain activity of neural circuits at extended timescales, several key questions remain open. First, what are the basic principles and the molecular machinery underlying invariant population dynamics of neural circuits, composed from intrinsically unstable activity patterns of individual neurons? Second, is homeostatic regulation compromised in Alzheimer's disease (AD) and do homeostatic failures lead to aberrant brain activity and memory decline, the overlapping phenotypes of AD and many other distinct neurodegenerative disorders? And finally, how do homeostatic systems operate in vivo under experience-dependent changes in firing rates and patterns? To target these questions, we have developed an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations, signaling processes at the level of single synapses and neuronal meta-plasticity. We will focus on hippocampal circuitry and combine ex vivo electrophysiology, single- and two-photon excitation imaging, time-resolved fluorescence microscopy and molecular biology, together with longitudinal monitoring of activity from large populations of hippocampal neurons in freely behaving mice. Utilizing these state-of-the-art approaches, we will determine how firing stability is maintained at different spatial scales and what are the mechanisms leading to destabilization of firing patterns in AD-related context. The proposed research will elucidate fundamental principles of neuronal function and offer conceptual insights into AD pathophysiology.
|year||authors and title||journal||last update|
Boaz Styr, Inna Slutsky
Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimerâ€™s disease
published pages: 463-473, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0080-x
|Nature Neuroscience 21/4||2019-06-06|
Samuel Frere, Inna Slutsky
Alzheimerâ€™s Disease: From Firing Instability to Homeostasis Network Collapse
published pages: 32-58, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.11.028
Heather C. Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N. Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M. Ranaivoson, Davide Comoletti, Jeffrey N. Savas, Han Remaut, Detlef Balschun, Keimpe D. Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit
Secreted amyloid-Î² precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
published pages: eaao4827, ISSN: 0036-8075, DOI: 10.1126/science.aao4827
Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.03.045
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