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MacroStability SIGNED

Stability and dynamics at different spatial scales: From physiology to Alzheimer's degeneration

Total Cost €


EC-Contrib. €






 MacroStability project word cloud

Explore the words cloud of the MacroStability project. It provides you a very rough idea of what is the project "MacroStability" about.

destabilization    suggest    ex    ad    molecular    principles    basic    constantly    underlying    single    balance    invariant    elucidate    circuits    hippocampal    rates    failures    firing    how    signaling    intrinsically    negative    resolved    spatial    diverse    context    feedback    disease    first    individual    unstable    fluorescence    homeostatic    time    phenotypes    spiking    imaging    brain    electrophysiology    plasticity    monitoring    dependent    compromised    stability    circuitry    changing    patterns    questions    decline    mechanisms    extended    theoretical    extensive    alzheimer    environment    microscopy    neurodegenerative    function    aberrant    conceptual    mice    dynamics    stabilize    overlapping    integrative    utilizing    synapses    photon    fundamental    vivo    behaving    meta    neurons    timescales    scales    point    pathophysiology    neural    disorders    longitudinal    ongoing    uncovered    combine    regulation    neuroscience    empirical    machinery    excitation    memory    biology    relationships    populations    operate    maintained    neuronal    insights    population   

Project "MacroStability" data sheet

The following table provides information about the project.


Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙000˙000.00


 Project objective

How neuronal circuits maintain the balance between stability and plasticity in a constantly changing environment remains one of the most fundamental questions in neuroscience. Empirical and theoretical studies suggest that homeostatic negative feedback mechanisms operate to stabilize the function of a system at a set point level of activity. While extensive research uncovered diverse homeostatic mechanisms that maintain activity of neural circuits at extended timescales, several key questions remain open. First, what are the basic principles and the molecular machinery underlying invariant population dynamics of neural circuits, composed from intrinsically unstable activity patterns of individual neurons? Second, is homeostatic regulation compromised in Alzheimer's disease (AD) and do homeostatic failures lead to aberrant brain activity and memory decline, the overlapping phenotypes of AD and many other distinct neurodegenerative disorders? And finally, how do homeostatic systems operate in vivo under experience-dependent changes in firing rates and patterns? To target these questions, we have developed an integrative approach to study the relationships between ongoing spiking activity of individual neurons and neuronal populations, signaling processes at the level of single synapses and neuronal meta-plasticity. We will focus on hippocampal circuitry and combine ex vivo electrophysiology, single- and two-photon excitation imaging, time-resolved fluorescence microscopy and molecular biology, together with longitudinal monitoring of activity from large populations of hippocampal neurons in freely behaving mice. Utilizing these state-of-the-art approaches, we will determine how firing stability is maintained at different spatial scales and what are the mechanisms leading to destabilization of firing patterns in AD-related context. The proposed research will elucidate fundamental principles of neuronal function and offer conceptual insights into AD pathophysiology.


year authors and title journal last update
List of publications.
2018 Boaz Styr, Inna Slutsky
Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease
published pages: 463-473, ISSN: 1097-6256, DOI: 10.1038/s41593-018-0080-x
Nature Neuroscience 21/4 2019-06-06
2018 Samuel Frere, Inna Slutsky
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
published pages: 32-58, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.11.028
Neuron 97/1 2019-06-06
2019 Heather C. Rice, Daniel de Malmazet, An Schreurs, Samuel Frere, Inge Van Molle, Alexander N. Volkov, Eline Creemers, Irena Vertkin, Julie Nys, Fanomezana M. Ranaivoson, Davide Comoletti, Jeffrey N. Savas, Han Remaut, Detlef Balschun, Keimpe D. Wierda, Inna Slutsky, Karl Farrow, Bart De Strooper, Joris de Wit
Secreted amyloid-β precursor protein functions as a GABA B R1a ligand to modulate synaptic transmission
published pages: eaao4827, ISSN: 0036-8075, DOI: 10.1126/science.aao4827
Science 363/6423 2019-06-06
2019 Boaz Styr, Nir Gonen, Daniel Zarhin, Antonella Ruggiero, Refaela Atsmon, Neta Gazit, Gabriella Braun, Samuel Frere, Irena Vertkin, Ilana Shapira, Michal Harel, Leore R. Heim, Maxim Katsenelson, Ohad Rechnitz, Saja Fadila, Dori Derdikman, Moran Rubinstein, Tamar Geiger, Eytan Ruppin, Inna Slutsky
Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.03.045
Neuron 2019-06-06

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