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MesoBrainMicr SIGNED

Novel high speed and high resolution microscopy setup for cytoarchitectonic studies of mesoscale sized human brain tissues, healthy and affected by Focal Cortical Dysplasia

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MesoBrainMicr project word cloud

Explore the words cloud of the MesoBrainMicr project. It provides you a very rough idea of what is the project "MesoBrainMicr" about.

levels    pathologies    acquired    massively    view    consequently    image    speed    interplay    microscope    inside    functioning    neuroanatonomy    models    inverted    physics    millimiters    neurobiology    science    centimeters    medical    competitiveness    sheet    light    neuroinformatics    brain    human    investigation    rounded    centimeter    host    strengthen    regions    tissues    match    emerge    resolving    acquisition    data    degenerative    atom    ranging    confocal    structure    intricate    perform    instrument    mysteries    organization    skill    building    healthy    researcher    microscopy    atlases    resolution    transfer    stimulated    programs    international    cytoarchitectonic    personality    perfect    hierarchy    recognition    decision    contributed    slit    functional    anatomy    sized    emotions    sub    dual    cortical    learning    leveraging    expert    setup    huge    neurobiological    neuro    tightly    optics    dysplasia    machine    progress    mesoscale    focal    algorithm    cellular    cold    fruitful    morphology    unwrapping    hardware    memory    foundation    shine    launch   

Project "MesoBrainMicr" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI FIRENZE 

Organization address
address: Piazza San Marco 4
city: Florence
postcode: 50121
website: http://www.unifi.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) coordinator 180˙277.00

Map

 Project objective

The human brain is a massively complex information processing system with a hierarchy of different yet tightly integrated levels of organization. From such intricate interplay emerge our personality, emotions, memory and decision making capabilities, but unwrapping the mysteries of the brain functioning represents a huge challenge. Recent progress in microscopy, neurobiology and neuroinformatics has stimulated the launch of large research programs such as Human Brain Project and BRAIN. An open problem is how to investigate with both high resolution and high speed the brain structure over mesoscale (millimiters to centimeters) sized regions, which would provide unique insight on the neuroanatonomy across different functional areas. This research project will develop a novel dual-view inverted dual-slit confocal light sheet microscope, capable of resolving sub-cellular morphology over centimeter-sized tissues at beyond state of the art acquisition speed. This instrument will be used to perform a comparative cytoarchitectonic investigation of mesoscale human brain tissues, both healthy and affected by Focal Cortical Dysplasia, leveraging an advanced machine learning image analysis algorithm. Such study will greatly advance the medical and neurobiological understanding of the effects of neuro-degenerative pathologies and the obtained data will be contributed to existing human brain atlases as a foundation for brain models. The applicant’s well-rounded skill set, acquired in cold atom physics and ranging from optics to hardware control, is a perfect match for building the proposed setup and for a fruitful two-way transfer of knowledge with the host, expert in advanced neuro microscopy. This research project will strengthen the competitiveness of European science and shine new light on the human brain anatomy, consequently it will raise the applicant's international recognition, and establish him inside Europe as a leading researcher in this quickly evolving field.

 Publications

year authors and title journal last update
List of publications.
2019 Giuseppe Sancataldo, Vladislav Gavryusev, Giuseppe de Vito, Lapo Turrini, Massimiliano Locatelli, Chiara Fornetto, Natascia Tiso, Francesco Vanzi, Ludovico Silvestri, Francesco Saverio Pavone
Flexible Multi-Beam Light-Sheet Fluorescence Microscope for Live Imaging Without Striping Artifacts
published pages: , ISSN: 1662-5129, DOI: 10.3389/fnana.2019.00007
Frontiers in Neuroanatomy 13 2019-06-03

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