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MicroMOUPE SIGNED

Microscopy - Making optimal use of photons and electrons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MicroMOUPE project word cloud

Explore the words cloud of the MicroMOUPE project. It provides you a very rough idea of what is the project "MicroMOUPE" about.

optically    probe    limits    interactions    self    specimen    pulses    plate    created    potentials    feasible    particle    times    shape    temporal    zernike    optimize    stanford    proteins    electron    switch    shot    realized    bright    tested    beam    coherent    creation    evading    nanometric    vienna    microscopy    adaptive    introducing    single    linear    fundamental    microscopes    enhancement    quadratic    pass    microscope    cells    sensitivity    pattern    experiment    laser    optimal    correction    particles    multiple    optics    nanoparticles    interact    proof    electro    cavities    sensitive    accuracy    blanking    dna    sub    arbitrary    limit    generator    optical    noise    resolution    metal    of    intense    scattered    ponderomotive    spatial    landscapes    demonstrated    aberration    fast    dark    modern    university    imaging    post    photons    limited    tool    free    overcoming    designed    signal    electrons    molecules    technologically    specimens    detection   

Project "MicroMOUPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://imaging.univie.ac.at/
 Total cost 1˙672˙752 €
 EC max contribution 1˙672˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙672˙752.00

Map

 Project objective

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

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The information about "MICROMOUPE" are provided by the European Opendata Portal: CORDIS opendata.

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