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DYNAMICE SIGNED

DYNAMICE: An integrated framework for biomechanical phenotyping of arteries to disentangle mechanical causes of arterial stiffening in diabetes

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "DYNAMICE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT MAASTRICHT 

Organization address
address: Minderbroedersberg 4-6
city: MAASTRICHT
postcode: 6200 MD
website: http://www.maastrichtuniversity.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 260˙929 €
 EC max contribution 260˙929 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) coordinator 260˙929.00
2    YALE UNIVERSITY US (NEW HAVEN) partner 0.00

Map

 Project objective

Accelerated arterial stiffening, an important complication in diabetes, increases cardiac workload eventually leading to heart failure. The arterial wall —consisting of elastin, collagen, smooth muscle, and glycosaminoglycans— may stiffen in diabetes due to 1) advanced glycation end-product (AGE)-induced collagen cross-linking, 2) calcification, or 3) changed glycosaminoglycan composition. The exact mechanical stiffening effects of these processes are unknown. Current preclinical, state-of-the-art measurement methods characterise arterial wall mechanics under static conditions. However, AGE-induced and glycosaminoglycan-associated wall stiffening may particularly affect dynamic characteristics (viscoelasticity) — especially relevant in vivo where arteries are subject to pulsatile blood pressure. The novel set-up for mechanical characterisation under such dynamic conditions I have previously developed still requires a matching computer modelling framework to correctly interpret the multidimensional, dynamic measurement data. I aim to 1) develop this modelling framework and 2) use it to quantify the characteristics of diabetes-associated stiffening processes by studying murine arteries with increased calcification, collagen cross-linking, glycosaminoglycan content, and combinations thereof. The forthcoming measurement platform —already sparking interest among international collaborators— enables realistic preclinical biomechanical arterial characterisation and will be the integrative keystone in my multidisciplinary research career. Its application to diabetes-associated arterial stiffening may yield breakthrough target and focus to further treatment of patients. Furthermore, its accessibility to (inter)national collaborators will be ensured by its implementation at the independent Special Skills & Advanced Phenotyping unit at the Maastricht University Biomedical Center — a dedicated core laboratory for phenotyping of small animal models.

 Publications

year authors and title journal last update
List of publications.
2019 Bart Spronck, Alexander W. Caulk, Abhay B. Ramachandra, Sae-Il Murtada, Alexia Rojas, Chang-Shun He, Matthew R. Bersi, George Tellides, Jay D. Humphrey
Genetic Background Dominates Fibrotic Aortic Remodeling During Angiotensin-Induced Hypertension in Mice
published pages: , ISSN: , DOI: 10.1101/727800
bioRxiv 2019-10-03
2019 Ingrid Tonhajzerova, Lucia Olexova, Alexander Jurko, Bart Spronck, Tomas Jurko, Nikola Sekaninova, Zuzana Visnovcova, Andrea Mestanikova, Erik Kudela, Michal Mestanik
Novel Biomarkers of Early Atherosclerotic Changes for Personalised Prevention of Cardiovascular Disease in Cervical Cancer and Human Papillomavirus Infection
published pages: 3720, ISSN: 1422-0067, DOI: 10.3390/ijms20153720
International Journal of Molecular Sciences 20/15 2019-10-03
2019 Bart Spronck, Michal Mestanik, Ingrid Tonhajzerova, Alexander Jurko, Isabella Tan, Mark Butlin, Alberto P. Avolio
Easy conversion of cardio-ankle vascular index into CAVI0
published pages: 1913-1914, ISSN: 0263-6352, DOI: 10.1097/hjh.0000000000002166
Journal of Hypertension 37/9 2019-10-03

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