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TARGETMENISCUS SIGNED

Targeting Meniscus Degradation in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 TARGETMENISCUS project word cloud

Explore the words cloud of the TARGETMENISCUS project. It provides you a very rough idea of what is the project "TARGETMENISCUS" about.

mass    molecular    my    healthy    members    principal    linked    regeneration    tears    matrix    leads    degeneration    revealed    oa    resolution    track    spectrometry    ageing    quality    continued    blood    tesla    expertise    patients    disease    collaborations    magnetic    knee    international    ups    analytical    total    meniscal    osteoarthritis    frequent    human    caused    knees    hard    prior    resonance    sequences    internationally    fluid    treatment    mri    replacements    donor    record    imaging    hyaline    combined    synovial    first    population    biobank    chemist    orthopaedic    tissue    compositional    trauma    degenerative    wp1    pharmaceutical    discover    degradation    cartilage    wp2    investigator    stage    proteomics    team    materials    burden    proteome    packages    preventing    undergo    arthroscopies    7t    dedication    ultra    joint    stimulating    operatively    modifying    physicist    medical    identification    consisting    menisci    goals    surgery    biomarkers    intervention    arthroscopy    surgeons    urgent    link    meniscus    biostatistician    follow    entity    proof    exploratory   

Project "TARGETMENISCUS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙973˙764 €
 EC max contribution 1˙973˙764 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙973˙764.00

Map

 Project objective

My goal is to determine the molecular degradation of meniscus tissue, a “new” disease that leads to degenerative meniscus tears and osteoarthritis (OA). My prior research has revealed that meniscus tears are a frequent entity in OA, not typically caused by knee trauma. By focusing on the meniscus, we aim to discover novel biomarkers and new targets for pharmaceutical intervention against OA, by preventing meniscus degradation and stimulating its regeneration. In our ageing population, the burden of OA is rapidly increasing, making the first disease-modifying OA treatment an urgent matter.

The proposal is based on my biobank consisting of human tissue from total knee joint replacements, knee arthroscopies, and healthy donor knees, including menisci, synovial fluid, hyaline cartilage, and blood. The two linked work packages are:

WP1 Proteomics: Identification of the proteome of the meniscal matrix and biomarkers of degeneration using exploratory and targeted mass spectrometry. WP2 7T imaging: Arthroscopy patients will undergo ultra-high field 7-Tesla magnetic resonance imaging (MRI) pre-operatively and at two follow-ups. Using both high-resolution and emerging compositional imaging sequences, we will determine meniscus matrix degradation and hyaline cartilage quality changes after knee surgery. Importantly, we will link proteomics with early stage knee OA development to provide proof-of-concept that the identified biomarkers and molecular treatment targets are associated with OA.

My key team members include orthopaedic surgeons, an analytical chemist with expertise in mass spectrometry, a medical physicist with expertise in MRI, and a biostatistician. We further work in international collaborations. As the principal investigator, I have an internationally recognized track record in OA research, with a novel focus on the meniscus. We will accomplish our goals by our combined expertise, unique materials, state-of-the-art methods, dedication, and continued hard work.

 Publications

year authors and title journal last update
List of publications.
2019 I. Kestilä, E. Folkesson, M.A. Finnilä, A. Turkiewicz, P. Önnerfjord, V. Hughes, J. Tjörnstrand, M. Englund, S. Saarakkala
Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis
published pages: 1790-1799, ISSN: 1063-4584, DOI: 10.1016/j.joca.2019.07.003
Osteoarthritis and Cartilage 27/12 2020-04-03
2020 Elin Folkesson, Aleksandra Turkiewicz, Martin Rydén, Harini Velocity Hughes, Neserin Ali, Jon Tjörnstrand, Patrik Önnerfjord, Martin Englund
Proteomic characterization of the normal human medial meniscus body using data‐independent acquisition mass spectrometry
published pages: , ISSN: 0736-0266, DOI: 10.1002/jor.24602
Journal of Orthopaedic Research 2020-04-03

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