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TARGETMENISCUS SIGNED

Targeting Meniscus Degradation in Osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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 TARGETMENISCUS project word cloud

Explore the words cloud of the TARGETMENISCUS project. It provides you a very rough idea of what is the project "TARGETMENISCUS" about.

link    continued    treatment    goals    physicist    surgery    frequent    discover    principal    expertise    orthopaedic    fluid    total    knee    ageing    degenerative    caused    international    undergo    prior    arthroscopies    joint    exploratory    linked    members    mass    menisci    leads    wp1    cartilage    modifying    patients    identification    biobank    proteome    tesla    packages    resonance    stimulating    meniscal    matrix    replacements    track    ups    degradation    ultra    disease    biomarkers    tissue    healthy    molecular    medical    operatively    collaborations    revealed    human    population    osteoarthritis    consisting    blood    imaging    proof    burden    internationally    magnetic    arthroscopy    urgent    biostatistician    investigator    donor    follow    tears    my    hard    7t    surgeons    first    chemist    combined    degeneration    knees    entity    trauma    team    hyaline    record    spectrometry    sequences    proteomics    oa    pharmaceutical    synovial    meniscus    intervention    quality    dedication    wp2    stage    regeneration    materials    resolution    analytical    compositional    mri    preventing   

Project "TARGETMENISCUS" data sheet

The following table provides information about the project.

Coordinator
LUNDS UNIVERSITET 

Organization address
address: Paradisgatan 5c
city: LUND
postcode: 22100
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙973˙764 €
 EC max contribution 1˙973˙764 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET SE (LUND) coordinator 1˙973˙764.00

Map

 Project objective

My goal is to determine the molecular degradation of meniscus tissue, a “new” disease that leads to degenerative meniscus tears and osteoarthritis (OA). My prior research has revealed that meniscus tears are a frequent entity in OA, not typically caused by knee trauma. By focusing on the meniscus, we aim to discover novel biomarkers and new targets for pharmaceutical intervention against OA, by preventing meniscus degradation and stimulating its regeneration. In our ageing population, the burden of OA is rapidly increasing, making the first disease-modifying OA treatment an urgent matter.

The proposal is based on my biobank consisting of human tissue from total knee joint replacements, knee arthroscopies, and healthy donor knees, including menisci, synovial fluid, hyaline cartilage, and blood. The two linked work packages are:

WP1 Proteomics: Identification of the proteome of the meniscal matrix and biomarkers of degeneration using exploratory and targeted mass spectrometry. WP2 7T imaging: Arthroscopy patients will undergo ultra-high field 7-Tesla magnetic resonance imaging (MRI) pre-operatively and at two follow-ups. Using both high-resolution and emerging compositional imaging sequences, we will determine meniscus matrix degradation and hyaline cartilage quality changes after knee surgery. Importantly, we will link proteomics with early stage knee OA development to provide proof-of-concept that the identified biomarkers and molecular treatment targets are associated with OA.

My key team members include orthopaedic surgeons, an analytical chemist with expertise in mass spectrometry, a medical physicist with expertise in MRI, and a biostatistician. We further work in international collaborations. As the principal investigator, I have an internationally recognized track record in OA research, with a novel focus on the meniscus. We will accomplish our goals by our combined expertise, unique materials, state-of-the-art methods, dedication, and continued hard work.

 Publications

year authors and title journal last update
List of publications.
2019 I. Kestilä, E. Folkesson, M.A. Finnilä, A. Turkiewicz, P. Önnerfjord, V. Hughes, J. Tjörnstrand, M. Englund, S. Saarakkala
Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis
published pages: 1790-1799, ISSN: 1063-4584, DOI: 10.1016/j.joca.2019.07.003
Osteoarthritis and Cartilage 27/12 2020-04-03
2020 Elin Folkesson, Aleksandra Turkiewicz, Martin Rydén, Harini Velocity Hughes, Neserin Ali, Jon Tjörnstrand, Patrik Önnerfjord, Martin Englund
Proteomic characterization of the normal human medial meniscus body using data‐independent acquisition mass spectrometry
published pages: , ISSN: 0736-0266, DOI: 10.1002/jor.24602
Journal of Orthopaedic Research 2020-04-03

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The information about "TARGETMENISCUS" are provided by the European Opendata Portal: CORDIS opendata.

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