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PREeclampsia risk stratification test: development of a suitable CALIbration framework for the analysis of a multiplex panel of endogenous compounds by LC-MS

Total Cost €


EC-Contrib. €






Project "PRECALI" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    METABOLOMIC DIAGNOSTICS LIMITED IE (Cork) coordinator 175˙866.00


 Project objective

PREeclampsia risk stratification test: development of CALIbration framework for the analysis of a multiplex panel of endogenous Compounds by LC-MS. Metabolomic Diagnostics (MDx) is an innovative company which is developing tests for pre-eclampsia in pregnancy. MDx consists of a team of scientists and entrepreneurs with clinical support. The enterprise and the experienced researcher propose to combine their expertise to support the development of a robust test for the risk stratification of preeclampsia. One of the key challenges in the product development is establishing the optimal way to perform the quantification of the metabolite targets underpinning the preeclmapsia test.

In the case of risk stratification products, the predictive metabolite biomarker profiles are merely a perturbation in the levels of a set of endogenous occurring metabolites. As a result, the internationally well-established LC-MS test validation framework as known for bioanalysis is not readily applicable.

The researcher’s doctoral dissertation focused on the development and subsequent validation of novel mass spectrometric assays for endogenous metabolites and she explored a novel validation strategy to overcome the limitations of the classic bioanalysis validation framework with regards to validation mass spectrometric assays for endogenous compounds. It would be difficult for MDx to find a candidate with a more relevant background for this project and it would be equally difficult for the researcher to find a company in Europe with such a perfect project to implement her expertise extensively.

The scope of this project is the development of an appropriate quantification strategy for the product, with the following prerequisites: - 1. Delivering robust quantification data which can be fed to the product risk stratification algorithm - 2. Delivering robust quantification data in a format which can be accepted by key stakeholders

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The information about "PRECALI" are provided by the European Opendata Portal: CORDIS opendata.

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