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Tracer-T SIGNED

Analysis of the effect of the tumour microenvironment on T cell functional phenotype

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "Tracer-T" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-10-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 195˙454.00

Map

 Project objective

A successful adaptive immune response requires T cells to be able to adopt a specific metabolic phenotype. However, in diseases such as cancer or those associated with chronic inflammation, the metabolic microenvironment in which a T cell functions is likely to subvert this metabolic phenotype, thereby disrupting function.

A better understanding of how the microenvironment can affect T cell function would permit the development of metabolic 'normalising' treatments that could restore function and permit disease resolution.

However, there is currently a disconnect within the field of immunometabolism that requires high resolution, direct analyses of T cell metabolism in order to solve. We therefore propose an approach that uses stable isotope-enriched metabolites that are associated with immunosuppressive cancer microenvironments (e.g. 13C3-lactate) to trace their use in different T cell populations (isolated from healthy peripheral blood), and thereby identify the precise pathway by which they are metabolised and how this alters cytotoxic function and proliferative capacity. By inhibiting the metabolic pathway implicated either pharmacologically, or using physiologically relevant stimuli (e.g. hypoxia), we will unequivocally link use of specific immunomodulatory metabolites, such as lactate, succinate and citrate, with T cell function.

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The information about "TRACER-T" are provided by the European Opendata Portal: CORDIS opendata.

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