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MECH-LoC SIGNED

Mechanically tuned Lung-on-a-Chip device to model pathology and drug screening for lung disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECH-LoC project word cloud

Explore the words cloud of the MECH-LoC project. It provides you a very rough idea of what is the project "MECH-LoC" about.

tune    synthetic    culture    regions    lung    mechanical    natural    toxicity    leader    exposed    screening    blending    elastic    disease    clinician    biomechanical    optimal    researcher    marketing    chip    collaborators    immersed    membrane    sac    medicine    dosing    efficacy    bioactivity    interfaces    microfluidic    matched    environment    chosen    complexity    richly    drugs    proteins    expertise    function    functional    gas    bronchiole    closely    profile    spatial    total    entrepreneurial    physiological    drug    tunable    validation    interface    candidate    er    mechanically    physiology    air    opportunity    stiffer    organ    experiences    regards    exquisite    integrate    training    model    polymers    consultation    conventional    ip    mimic    regenerative    unmet    platform    cellular    stiff    alveolar    equivalent    models    cells    clinicians    fabrication    superior    perfusion    stiffness    incorporate    elvesys    patient    treatments    patenting    biomaterial    permeable    cues    vitro    cell    device    benchmarking    liquid    create   

Project "MECH-LoC" data sheet

The following table provides information about the project.

Coordinator
ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-10-15   to  2020-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The aim of this project is to design a total lung-on-a-chip microfluidic device with a mechanically relevant air-liquid interface to create a cellular environment with more closely matched physiological and functional complexity than conventional lung models. Specifically, we will (i) integrate bronchiole and alveolar sac functional regions of the lung into one chip, and (ii) incorporate a relevant and tunable biomechanical profile into the gas-permeable membrane (mimic of air-liquid interface). This device will address the large and currently unmet need to model organ-level complexity of cells in vitro, in particular with regards to spatial and mechanical cues important for cell function, and provide a superior platform to model lung physiology, function and lung disease treatments. The project will be based on the state-of-the-art technical expertise of Elvesys in microfluidic chip design, fabrication and exquisite control of microfluidic parameters for advanced cell culture, and will fully integrate the Experienced Researcher’s (ER) strong expertise with elastic proteins, liquid interfaces, biomaterial design and mechanical testing to tune membrane stiffness and bioactivity by blending synthetic polymers and natural elastic proteins. Testing, validation and benchmarking of the product will be by perfusion using a set of candidate drugs chosen in consultation with clinician collaborators. This technology will offer clinicians a choice of lung model that is mechanically relevant to a patient’s lung profile (e.g. equivalent to physiological, stiffer or less stiff) for pre-screening of drug efficacy, dosing and toxicity. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at Elvesys and exposed to marketing concepts, IP and patenting. Together, these experiences will provide the ER with the optimal training environment to become a leader in regenerative medicine.

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The information about "MECH-LOC" are provided by the European Opendata Portal: CORDIS opendata.

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