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MECH-LoC SIGNED

Mechanically tuned Lung-on-a-Chip device to model pathology and drug screening for lung disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECH-LoC project word cloud

Explore the words cloud of the MECH-LoC project. It provides you a very rough idea of what is the project "MECH-LoC" about.

screening    chosen    culture    physiology    perfusion    regions    efficacy    clinician    expertise    incorporate    benchmarking    matched    unmet    disease    candidate    platform    sac    opportunity    proteins    mechanically    patient    dosing    membrane    toxicity    stiffness    validation    cues    optimal    consultation    interface    cellular    marketing    patenting    vitro    clinicians    profile    stiff    model    spatial    gas    fabrication    air    stiffer    cells    organ    exquisite    equivalent    natural    permeable    immersed    experiences    closely    complexity    er    models    integrate    medicine    create    superior    treatments    bronchiole    elvesys    synthetic    mimic    biomaterial    lung    entrepreneurial    exposed    tunable    ip    cell    researcher    total    liquid    microfluidic    drugs    environment    drug    physiological    mechanical    bioactivity    functional    function    chip    conventional    regards    device    elastic    tune    regenerative    training    leader    blending    biomechanical    polymers    interfaces    richly    alveolar    collaborators   

Project "MECH-LoC" data sheet

The following table provides information about the project.

Coordinator
ELVESYS 

Organization address
address: 1-3 BIS RUE ROBERT ET SONIA DELAUNAY
city: PARIS
postcode: 75011
website: www.elvesys.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-10-15   to  2020-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ELVESYS FR (PARIS) coordinator 173˙076.00

Map

 Project objective

The aim of this project is to design a total lung-on-a-chip microfluidic device with a mechanically relevant air-liquid interface to create a cellular environment with more closely matched physiological and functional complexity than conventional lung models. Specifically, we will (i) integrate bronchiole and alveolar sac functional regions of the lung into one chip, and (ii) incorporate a relevant and tunable biomechanical profile into the gas-permeable membrane (mimic of air-liquid interface). This device will address the large and currently unmet need to model organ-level complexity of cells in vitro, in particular with regards to spatial and mechanical cues important for cell function, and provide a superior platform to model lung physiology, function and lung disease treatments. The project will be based on the state-of-the-art technical expertise of Elvesys in microfluidic chip design, fabrication and exquisite control of microfluidic parameters for advanced cell culture, and will fully integrate the Experienced Researcher’s (ER) strong expertise with elastic proteins, liquid interfaces, biomaterial design and mechanical testing to tune membrane stiffness and bioactivity by blending synthetic polymers and natural elastic proteins. Testing, validation and benchmarking of the product will be by perfusion using a set of candidate drugs chosen in consultation with clinician collaborators. This technology will offer clinicians a choice of lung model that is mechanically relevant to a patient’s lung profile (e.g. equivalent to physiological, stiffer or less stiff) for pre-screening of drug efficacy, dosing and toxicity. Through this opportunity the ER will be immersed in a richly entrepreneurial environment at Elvesys and exposed to marketing concepts, IP and patenting. Together, these experiences will provide the ER with the optimal training environment to become a leader in regenerative medicine.

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The information about "MECH-LOC" are provided by the European Opendata Portal: CORDIS opendata.

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