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MITIG SIGNED

Addressing MITochondrial Import by Glioblastoma cells to rewire respiratory metabolism

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MITIG project word cloud

Explore the words cloud of the MITIG project. It provides you a very rough idea of what is the project "MITIG" about.

incorporation    cells    retrograde    mitochondria    progression    regulation    modulation    economic    resistance    respiratory    relevance    international    glioblastoma    despite    tumour    either    departing    mitochondrial    resection    overcoming    avidly    cure    multiforme    seeking    dire    function    bioenergetic    virtual    lasting    reported    multidisciplinary    paving    respiration    questions    exerted    mitigate    transferred    capitalizes    exogenous    content    public    treatments    metabolism    rewire    msca    remodel    radiation    primary    central    escape    biomedical    training    network    vivo    adults    aggressive    metabolic    neural    impacts    sum    frequent    gliomas    acquisition    gbm    redefine    paths    organelle    surrounding    mitig    tool    cancer    socio    isolated    cell    brain    prognosis    disease    cancers    tumours    hence    rewiring    chemotherapy    intersectorial    import    importation    engagement    counteract    experts    signalling    facets    malignancy    therapeutic   

Project "MITIG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SALAMANCA 

Organization address
address: CALLE PATIO DE ESCUELAS 1
city: SALAMANCA
postcode: 37008
website: www.usal.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SALAMANCA ES (SALAMANCA) coordinator 158˙121.00

Map

 Project objective

Glioblastoma multiforme (GBM) represents the most frequent and aggressive type of primary brain tumours in adults. Despite significant advances, current treatments involving resection and radiation/chemotherapy only partially mitigate the dire prognosis for GBM, hence avidly seeking for novel therapeutic approaches against a disease with still no virtual cure and a high socio-economic impact in the EU. A common feature in GBM, as in many other cancers, is their escape to the retrograde signalling and metabolic regulation exerted by mitochondria -the bioenergetic central of the cell. Modulation of mitochondrial function thus represents a primary target to rewire metabolism and counteract tumour progression and chemotherapy resistance. MITIG capitalizes on the recent reported ability of gliomas to import exogenous mitochondria, either isolated or transferred from surrounding neural cells in the brain, to foster tumour development and malignancy in vivo. MITIG will target both paths for mitochondrial importation to remodel organelle content and address i) how incorporation of exogenous mitochondria impacts respiratory metabolism in GBM cells and iii) the relevance of this metabolic rewiring for tumour development in vivo. Departing from mitochondrial acquisition as a novel tool to redefine respiration and metabolism in cancer, MITIG will develop a comprehensive training program fostering MSCA and EU values on research, dissemination and public engagement. An international network of experts will support the training in the intersectorial, multidisciplinary facets of MITIG. In sum, while paving the way for a promising novel biomedical field, MITIG aims at providing novel therapeutic targets and overcoming long lasting questions on respiratory metabolism in GBM and cancer as a whole.

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The information about "MITIG" are provided by the European Opendata Portal: CORDIS opendata.

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