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MITIG SIGNED

Addressing MITochondrial Import by Glioblastoma cells to rewire respiratory metabolism

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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 MITIG project word cloud

Explore the words cloud of the MITIG project. It provides you a very rough idea of what is the project "MITIG" about.

paths    malignancy    vivo    primary    acquisition    engagement    metabolism    tool    rewiring    progression    chemotherapy    mitochondrial    virtual    network    escape    respiration    radiation    overcoming    tumours    gbm    gliomas    departing    adults    prognosis    despite    treatments    public    signalling    cell    facets    cancers    neural    exogenous    content    metabolic    counteract    therapeutic    intersectorial    frequent    retrograde    sum    hence    incorporation    capitalizes    central    reported    aggressive    transferred    glioblastoma    mitig    brain    multidisciplinary    experts    organelle    exerted    socio    regulation    paving    international    lasting    resistance    biomedical    economic    isolated    either    impacts    avidly    function    relevance    surrounding    multiforme    training    remodel    modulation    cells    cancer    seeking    rewire    tumour    dire    mitigate    cure    resection    questions    redefine    mitochondria    respiratory    bioenergetic    importation    import    disease    msca   

Project "MITIG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SALAMANCA 

Organization address
address: CALLE PATIO DE ESCUELAS 1
city: SALAMANCA
postcode: 37008
website: www.usal.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SALAMANCA ES (SALAMANCA) coordinator 158˙121.00

Map

 Project objective

Glioblastoma multiforme (GBM) represents the most frequent and aggressive type of primary brain tumours in adults. Despite significant advances, current treatments involving resection and radiation/chemotherapy only partially mitigate the dire prognosis for GBM, hence avidly seeking for novel therapeutic approaches against a disease with still no virtual cure and a high socio-economic impact in the EU. A common feature in GBM, as in many other cancers, is their escape to the retrograde signalling and metabolic regulation exerted by mitochondria -the bioenergetic central of the cell. Modulation of mitochondrial function thus represents a primary target to rewire metabolism and counteract tumour progression and chemotherapy resistance. MITIG capitalizes on the recent reported ability of gliomas to import exogenous mitochondria, either isolated or transferred from surrounding neural cells in the brain, to foster tumour development and malignancy in vivo. MITIG will target both paths for mitochondrial importation to remodel organelle content and address i) how incorporation of exogenous mitochondria impacts respiratory metabolism in GBM cells and iii) the relevance of this metabolic rewiring for tumour development in vivo. Departing from mitochondrial acquisition as a novel tool to redefine respiration and metabolism in cancer, MITIG will develop a comprehensive training program fostering MSCA and EU values on research, dissemination and public engagement. An international network of experts will support the training in the intersectorial, multidisciplinary facets of MITIG. In sum, while paving the way for a promising novel biomedical field, MITIG aims at providing novel therapeutic targets and overcoming long lasting questions on respiratory metabolism in GBM and cancer as a whole.

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The information about "MITIG" are provided by the European Opendata Portal: CORDIS opendata.

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