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MITIG SIGNED

Addressing MITochondrial Import by Glioblastoma cells to rewire respiratory metabolism

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MITIG project word cloud

Explore the words cloud of the MITIG project. It provides you a very rough idea of what is the project "MITIG" about.

exerted    brain    impacts    tumours    tool    remodel    treatments    seeking    multiforme    radiation    primary    biomedical    acquisition    respiratory    escape    neural    intersectorial    organelle    public    exogenous    mitigate    resection    training    economic    rewire    malignancy    retrograde    departing    tumour    adults    bioenergetic    paths    reported    mitochondria    frequent    international    vivo    central    either    mitochondrial    overcoming    dire    signalling    chemotherapy    hence    progression    experts    gliomas    cells    surrounding    socio    network    relevance    facets    resistance    incorporation    despite    mitig    paving    capitalizes    isolated    multidisciplinary    metabolism    importation    respiration    cancer    regulation    prognosis    gbm    function    engagement    sum    lasting    import    modulation    redefine    avidly    cell    questions    cure    cancers    glioblastoma    counteract    therapeutic    disease    transferred    aggressive    rewiring    metabolic    content    virtual    msca   

Project "MITIG" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SALAMANCA 

Organization address
address: CALLE PATIO DE ESCUELAS 1
city: SALAMANCA
postcode: 37008
website: www.usal.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SALAMANCA ES (SALAMANCA) coordinator 158˙121.00

Map

 Project objective

Glioblastoma multiforme (GBM) represents the most frequent and aggressive type of primary brain tumours in adults. Despite significant advances, current treatments involving resection and radiation/chemotherapy only partially mitigate the dire prognosis for GBM, hence avidly seeking for novel therapeutic approaches against a disease with still no virtual cure and a high socio-economic impact in the EU. A common feature in GBM, as in many other cancers, is their escape to the retrograde signalling and metabolic regulation exerted by mitochondria -the bioenergetic central of the cell. Modulation of mitochondrial function thus represents a primary target to rewire metabolism and counteract tumour progression and chemotherapy resistance. MITIG capitalizes on the recent reported ability of gliomas to import exogenous mitochondria, either isolated or transferred from surrounding neural cells in the brain, to foster tumour development and malignancy in vivo. MITIG will target both paths for mitochondrial importation to remodel organelle content and address i) how incorporation of exogenous mitochondria impacts respiratory metabolism in GBM cells and iii) the relevance of this metabolic rewiring for tumour development in vivo. Departing from mitochondrial acquisition as a novel tool to redefine respiration and metabolism in cancer, MITIG will develop a comprehensive training program fostering MSCA and EU values on research, dissemination and public engagement. An international network of experts will support the training in the intersectorial, multidisciplinary facets of MITIG. In sum, while paving the way for a promising novel biomedical field, MITIG aims at providing novel therapeutic targets and overcoming long lasting questions on respiratory metabolism in GBM and cancer as a whole.

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The information about "MITIG" are provided by the European Opendata Portal: CORDIS opendata.

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