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NORMAL-LOAD SIGNED

NORmalize MusculoskeletAL LOadings to Avoid bony Deformities in children with cerebral palsy

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "NORMAL-LOAD" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 160˙800.00

Map

 Project objective

Muscle contractions in children with cerebral palsy (CP) cause abnormal musculoskeletal loading, which can lead to bony deformities. Deformities of the femur are commonly corrected by de-rotation osteotomies. In children, early clinical interventions, which aim to normalize the loading of the musculoskeletal system, could influence bone growth and prevent the development of bony deformities. To investigate this assumption, I will use musculoskeletal (MSK) models to calculate the loading conditions of the femur before and after Botulinum Toxin-A injections (BTI) in lower limb muscles. The obtained loading conditions will then be used as input for a mechanobiological finite element analysis (FEA) model to assess the impact of altered loading conditions on femoral bone growth. With this simulation platform, I will use the patient’s gait pattern and BTI treatment history to relate the loading conditions to the femoral deformities and compare these to the measured deformities from medical images. If BTI or similar load-modifying clinical interventions can be used to reduce the number of surgical corrections, it will decrease the burden on the child as well as decrease the socio-economic costs related to the treatment of children with CP. During my PhD at Griffith University (Australia), I compared different methods and models for clinical gait analysis and showed that MSK models can be confidentially used in children with CP. With this project, I strive to go one-step further and show that MSK loadings in combination with a mechanobiological model can be used to enhance our understanding of the impact of clinical interventions and, therefore, improve the treatment planning in children with CP. I am highly motivated to take on the challenge and acquire the new scientific and transferable skills, which will strengthen my profile for future grant proposals and increase my opportunities for a permanent position after the fellowship.

 Publications

year authors and title journal last update
List of publications.
2018 S. Van Rossom, H. Kainz, M. Wesseling, E. Papageorgiou, F. De Groote, A. Van Campenhout, K. Desloovere, I. Jonkers
O 024—Joint loading is normalized following single-event multilevel surgery and partly normalized following botulinum injections in cerebral palsy patients
published pages: 48-49, ISSN: 0966-6362, DOI: 10.1016/j.gaitpost.2018.06.042
Gait & Posture 65 2020-04-24
2018 M. Wesseling, T. Hoekstra, H. Kainz, S. Van Rossom, K. Desloovere, F. De Groote, I. Jonkers
O 021 – Does including EMG data in the estimation of muscle forces alter the evaluation of the effect of botulinum toxin injections?
published pages: 41-42, ISSN: 0966-6362, DOI: 10.1016/j.gaitpost.2018.06.039
Gait & Posture 65 2020-04-24
2018 M. Wesseling, I. Vandekerckhove, T. Hoekstra, Hans Kainz, G. Molenaers, F. De Groote, K. Desloovere, I. Jonkers
O 053 - Femoral deformities affect gait performance more than hip muscle weakness
published pages: 110-111, ISSN: 0966-6362, DOI: 10.1016/j.gaitpost.2018.06.086
Gait & Posture 65 2020-04-24
2019 Hans Kainz, Hoa Hoang, Lorenzo Pitto, Mariska Wesseling, Sam Van Rossom, Anja Van Campenhout, Guy Molenaers, Friedl De Groote, Kaat Desloovere, Ilse Jonkers
Selective dorsal rhizotomy improves muscle forces during walking in children with spastic cerebral palsy
published pages: 26-33, ISSN: 0268-0033, DOI: 10.1016/j.clinbiomech.2019.03.014
Clinical Biomechanics 65 2020-04-24
2018 H. Kainz, M. Wesseling, L. Pitto, A. Falisse, S. Van Rossom, A. Van Campenhout, F. De Groote, K. Desloovere, C. Carty, I. Jonkers
O 107 – Impact of subject-specific musculoskeletal geometry on estimated joint kinematics, joint kinetics and muscle forces in typically developing children
published pages: 223-225, ISSN: 0966-6362, DOI: 10.1016/j.gaitpost.2018.06.142
Gait & Posture 65 2020-04-24

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