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INTEPOL SIGNED

Elucidating polarity pathways in the fly and murine intestinal epithelium

Total Cost €

EC-Contrib. €

Partnership

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INTEPOL project word cloud

Explore the words cloud of the INTEPOL project. It provides you a very rough idea of what is the project "INTEPOL" about.

asymmetric biology divisions universally cells polarization alternative organoids emerges hallmark unlike organization extensive newly mechanisms elucidate intestinal insights little screen types conduct conservation gut epithelium human integral recurring conserved unconventional regulators genetic cell malignancies polarity normal dependent murine migration drive epithelial tissue context stem functional function canonical drosophila developmental epithelia axis manner helped model shed diverse fly examine

Project "INTEPOL" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-04-05 to 2020-04-04

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

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Project objective

Cell polarity is essential for normal cell function and for various developmental processes, such as axis determination, asymmetric stem cell divisions, and cell migration. Polarity is integral for tissue organization and failure in this process is a hallmark of human malignancies. Extensive studies in diverse model systems have helped to establish recurring mechanisms that drive polarity in various cell types. Yet, these conserved polarity regulators are not universally required and it emerges that some cells use distinct polarity mechanisms in a context dependent manner. For example, the polarization of the Drosophila intestinal epithelium does not require any of the canonical polarity regulators, unlike all other well-characterized Drosophila epithelia. However, little is known about how this unconventional polarity is established. This proposal aims to elucidate novel alternative polarity pathways in the intestinal epithelium of Drosophila. I will conduct a large--scale forward genetic screen to identify novel polarity regulators in the fly gut epithelium. Furthermore, I will examine the functional conservation of the newly identified polarity regulators in the murine intestinal stem cell organoids. Overall, this proposal will shed novel insights into the epithelial biology of the intestinal system.

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