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TissueMaps SIGNED

Elemental imaging of human tissue: clinical therapy support and development of new diagnostics

Total Cost €

EC-Contrib. €

Partnership

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TissueMaps project word cloud

Explore the words cloud of the TissueMaps project. It provides you a very rough idea of what is the project "TissueMaps" about.

costly hip replacements failures frequent ranging ppm sensitivities clinic incorporated reveal desorbed lacking types ing ray analysing emission significantly origin belong biological rejection body entering treatments human scientific incorporation degradation ions loosening hospitals screening chemical lateral aging implants sub action tissues physiology implant proved proton mapping health reports population elemental lack destructive besides mass introduction revealed surrounding quantitative optical modern tissue technique inflammation scans rejections socioeconomic details causing microscopies prosthesis resolution therapies capability context micropixe physiological ageing sensitivity cellular microscopy insufficient techniques countries micro localization

Project "TissueMaps" data sheet

The following table provides information about the project.

Coordinator	INSTITUT JOZEF STEFAN Organization address address: Jamova 39 city: LJUBLJANA postcode: 1000 website: www.ijs.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Slovenia [SI]
Total cost	157˙287 €
EC max contribution	157˙287 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-CAR
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT JOZEF STEFAN INSTITUT JOZEF STEFAN Organization address address: Jamova 39 city: LJUBLJANA postcode: 1000 website: www.ijs.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	coordinator	157˙287.00

Map

Project objective

Population in developed countries is aging. Besides other socioeconomic effects, this significantly affects European health systems, as ageing-specific therapies and treatments have become important cost factors. In this context, hip replacements belong to one of the most frequent and costly treatments. Recent reports on mass failures of new types of hip prosthesis revealed insufficient understanding of physiological processes leading to prosthesis failure. Studies on hip prosthesis failures revealed complex processes leading to chemical degradation of implants, resulting in desorbed elements and ions entering the surrounding tissue, causing inflammation and loosening of hip prosthesis. The research needed to reveal important details of the body response to the implant is lacking of the incorporation of novel techniques and approaches. Techniques currently applied in hospitals, such as X-ray scans and optical tissue microscopies do not fully explain the effects of implants on the body physiology. Moreover, the screening of new types of implants before its introduction into clinic processes may lack of scientific understanding of possible destructive effects. Modern tissue microscopy techniques are promising providing elemental and chemical distribution of a tissue, with high sensitivities and lateral resolution. Micro Proton Induced X-ray Emission (microPIXE) allows determining the quantitative elemental mapping of a tissue and has been proved to be the best technique for element localization studies in biological tissues due to its capability of analysing at sub-cellular level the distribution of elements incorporated to biological tissue, due to a high sensitivity ranging down to 0.1 ppm level. The action will focus on investigating reasons of failures and rejections of hip replacements by application of advanced elemental microscopies to human tissue surrounding hip failures. Results may determine the origin of failure and avoid prosthesis rejection.

Publications

List of publications.
year	authors and title	journal	last update
2020	Esther PunzÃ³n-Quijorna, Mitja Kelemen, PrimoÅ¾ VavpetiÄ, Rajko Kavalar, PrimoÅ¾ Pelicon, Samo K. Fokter Particle Induced X-ray Emission (PIXE) for elemental tissue imaging in hip modular prosthesis fracture case published pages: 182-186, ISSN: 0168-583X, DOI: 10.1016/j.nimb.2019.10.019	Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 462	2019-12-16

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The information about "TISSUEMAPS" are provided by the European Opendata Portal: CORDIS opendata.