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BIORECAR SIGNED

Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BIORECAR project word cloud

Explore the words cloud of the BIORECAR project. It provides you a very rough idea of what is the project "BIORECAR" about.

maximise    natural    mature    drug    bioartificial    innovation    agents    multifunctional    myocardial    platform    polyurethane    direct    industrial    secreted    biomaterial    model    mixture    engineered    conversion    fibroblasts    vitro    thermosensitive    validation    scaffolds    tissue    hydrogel    tool    complexity    scientific    3d    cell    fibrotic    cardiomyocytes    technological    collaborations    situ    adapt    versatile    tests    matrix    recapitulating    biomatrix    expertise    respect    extracellular    loaded    polymer    biorecar    constituents    clinics    translation    release    clinical    reduce    signalling    stimulating    blend    stimulate    therapy    first    polyurethanes    opening    materials    animal    nanoparticles    breakthrough    chemistry    biomaterials    innovative    biochemical    efficient    efforts    multidisciplinary    cues    functional    innovations    nanomedicine    accelerated    injectable    human    protein    reprogramming    cardiac    nature    biomimetic    recruitment    regeneration    infarction    therapeutics   

Project "BIORECAR" data sheet

The following table provides information about the project.

Coordinator
POLITECNICO DI TORINO 

Organization address
address: CORSO DUCA DEGLI ABRUZZI 24
city: TORINO
postcode: 10129
website: www.polito.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI TORINO IT (TORINO) coordinator 1˙875˙000.00
2    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 125˙000.00

Map

 Project objective

In BIORECAR I will develop a new breakthrough multifunctional biomaterial-based platform for myocardial regeneration after myocardial infarction, provided with biochemical cues able to enhance the direct reprogramming of human cardiac fibroblasts into functional cardiomyocytes. My expertise in bioartificial materials and biomimetic scaffolds and the versatile chemistry of polyurethanes will be the key elements to achieve a significant knowledge and technological advancement in cell reprogramming therapy, opening the way to the future translation of the therapy into the clinics. I will implement this advanced approach through the design of a novel 3D in vitro tissue-engineered model of human cardiac fibrotic tissue, as a tool for testing and validation, to maximise research efforts and reduce animal tests. I will adapt novel nanomedicine approaches I have recently developed for drug release to design innovative cell-friendly and efficient polyurethane nanoparticles for targeted reprogramming of cardiac fibroblasts. I will design an injectable bioartificial hydrogel based on a blend of a thermosensitive polyurethane and a natural component selected among a novel cell-secreted natural polymer mixture (“biomatrix”) recapitulating the complexity of cardiac extracellular matrix or one of its main protein constituents. Such multifunctional hydrogel will deliver in situ agents stimulating recruitment of cardiac fibroblasts together with the nanoparticles loaded with reprogramming therapeutics, and will provide biochemical signalling to stimulate efficient conversion of fibroblasts into mature cardiomyocytes. First-in-field biomaterials-based innovations introduced by BIORECAR will enable more effective regeneration of functional myocardial tissue respect to state-of-the art approaches. BIORECAR innovation is multidisciplinary in nature and will be accelerated towards future clinical translation through my clinical, scientific and industrial collaborations.

 Publications

year authors and title journal last update
List of publications.
2019 Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
INFLUENCE OF 3D CULTURE MICROENVIRONMENT ON MICRORNA-MEDIATED DIRECT REPROGRAMMING OF HUMAN CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES
published pages: 32, ISSN: , DOI:
Advanced Cell Therapies and Tissue Engineering 2020-03-05
2019 Valeria Chiono, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Irene Carmagnola
IN VITRO MODELS OF HUMAN PATHOLOGICAL CARDIAC TISSUE VIA BIOARTIFICIAL SCAFFOLDS
published pages: 28, ISSN: , DOI:
Advanced Cell Therapies and Tissue Engineering 2020-03-05
2018 Chiono, Valeria; Paoletti, Camilla; Carla, Divieto; Franca Di Meglio,; Clotilde, Castaldo; Daria, Nurzynska
Direct cell reprogramming as a new emerging strategy in cardiac regeneration
published pages: 14, ISSN: , DOI:
Termis WC 2018 programme 2020-03-05
2019 Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Lipoplexes for miRNA delivery in myocardial regeneration
published pages: 136, ISSN: , DOI:
Nano Day IV Program and Book of Abstracts 2020-03-05
2020 Nathalie Steimberg
iPS, organoids and 3D models as advanced tools for in vitro toxicology
published pages: 136-140, ISSN: 1868-596X, DOI: 10.14573/altex.1911071
ALTEX 2020-03-05
2019 Carmagnola, Irene; Zoso, Alice; Chiono, Valeria
In vitro models of human pathological cardiac tissue via bioartificial scaffolds
published pages: \"#1011\", ISSN: , DOI:
European Society for Biomaterials (ESB) 2019 programme 2020-03-05
2019 Valeria Chiono
Direct reprogramming of human fibroblasts as a novel tool in cardiac tissue engineering
published pages: 813, ISSN: , DOI:
TERMIS EU2019 Conference Book 2020-03-05
2019 Carmagnola, Irene; Zoso, Alice; Chiono, Valeria
In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds
published pages: 29, ISSN: 2194-0479, DOI:
ALTEX Proceeding 2020-03-05
2019 Camilla, Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics
published pages: 74, ISSN: , DOI:
JRC Summer School 2019: Non-Animal Aprroaches in Science. Challenges & Future Directions 2020-03-05
2020 Alice Zoso, Irene Carmagnola, Gerardina Ruocco, Mattia Spedicati, Valeria Chiono
In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds
published pages: 1, ISSN: 2531-9892, DOI: 10.4081/bse.2019.122
Biomedical Science and Engineering 2020-03-05
2019 Chiono, Valeria; Laurano, Rossella; Zoso, Alice; Boffito, Monica
Thermosensitive bioartificial hydrogels as smart injectable and biocompatible systems allowing post-injection chemical crosslinking
published pages: \"#943\", ISSN: , DOI:
European Society for Biomaterials (ESB) programme 2020-03-05
2019 Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNAmimics
published pages: 1442, ISSN: , DOI:
Termis EU 2019 Conference Book 2020-03-05
2019 Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
MicroRNA delivery through nanoparticles
published pages: 80-95, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.007
Journal of Controlled Release 313 2020-03-05
2018 Camilla Paoletti, Carla Divieto, Valeria Chiono
Impact of Biomaterials on Differentiation and Reprogramming Approaches for the Generation of Functional Cardiomyocytes
published pages: 114, ISSN: 2073-4409, DOI: 10.3390/cells7090114
Cells 7/9 2019-05-03

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