Explore the words cloud of the DEVINCI project. It provides you a very rough idea of what is the project "DEVINCI" about.
The following table provides information about the project.
KING'S COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙500˙000 €|
|EC max contribution||2˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-07-01 to 2023-06-30|
Take a look of project's partnership.
|1||KING'S COLLEGE LONDON||UK (LONDON)||coordinator||2˙500˙000.00|
The mammalian neocortex consists of discrete, but highly interconnected, functional areas that collectively encode features of the environment, form associations between stimuli and drive behaviour by transforming sensory input into motor output. All neocortical areas are organised into six layers containing two major classes of neurons, excitatory glutamatergic pyramidal cells and inhibitory GABAergic interneurons. However, each area has distinctive cytoarchitectonical features and inputs that largely determine its computational capabilities. As pyramidal cells comprise the large majority of neurons in the cerebral cortex, much emphasis has been made on their contribution to the differential organisation of cortical areas. In contrast, interneurons have received little attention in the context of the functional specialisation of cortical areas, even though their distribution is highly heterogeneous.
The central tenet of this research proposal is that distinct patterns of inhibitory connectivity may accompany, and perhaps even determine, the functional specialisation of neocortical areas. We hypothesise that interneurons play an important role in the tuning of circuits in each cortical area, and therefore that quantitative differences in the relative distribution of specific classes of interneurons, which arise during development, reflect functional specialisations. The overall aim of this research project is to understand how developmental mechanisms ‘sculpting’ the distribution of inhibitory neurons across different neocortical areas contribute to their functional specialisation. This project has the potential to transform our understanding of the organisation of inhibitory circuits in the mammalian neocortex.
|Data Management Plan||Open Research Data Pilot||2020-04-11 08:48:25|
Take a look to the deliverables list in detail: detailed list of DEVINCI deliverables.
|year||authors and title||journal||last update|
Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian FernÃ¡ndez-Otero, Carmen Streicher, Sebastian J Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marin
A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.51381
Lynette Lim, Da Mi, Alfredo Llorca, Oscar MarÃn
Development and Functional Diversification of Cortical Interneurons
published pages: 294-313, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.10.009
Fong Kuan Wong, Oscar MarÃn
Developmental Cell Death in the Cerebral Cortex
published pages: 523-542, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-100818-125204
|Annual Review of Cell and Developmental Biology 35/1||2020-04-11|
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