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DEVINCI SIGNED

Developmental principles for the functional specialisation of inhibitory circuits in neocortical areas

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EC-Contrib. €

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Project "DEVINCI" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://devneuro.org.uk/marinlab/Default.aspx
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 2˙500˙000.00

Map

 Project objective

The mammalian neocortex consists of discrete, but highly interconnected, functional areas that collectively encode features of the environment, form associations between stimuli and drive behaviour by transforming sensory input into motor output. All neocortical areas are organised into six layers containing two major classes of neurons, excitatory glutamatergic pyramidal cells and inhibitory GABAergic interneurons. However, each area has distinctive cytoarchitectonical features and inputs that largely determine its computational capabilities. As pyramidal cells comprise the large majority of neurons in the cerebral cortex, much emphasis has been made on their contribution to the differential organisation of cortical areas. In contrast, interneurons have received little attention in the context of the functional specialisation of cortical areas, even though their distribution is highly heterogeneous.

The central tenet of this research proposal is that distinct patterns of inhibitory connectivity may accompany, and perhaps even determine, the functional specialisation of neocortical areas. We hypothesise that interneurons play an important role in the tuning of circuits in each cortical area, and therefore that quantitative differences in the relative distribution of specific classes of interneurons, which arise during development, reflect functional specialisations. The overall aim of this research project is to understand how developmental mechanisms ‘sculpting’ the distribution of inhibitory neurons across different neocortical areas contribute to their functional specialisation. This project has the potential to transform our understanding of the organisation of inhibitory circuits in the mammalian neocortex.

 Deliverables

List of deliverables.
Data Management Plan Open Research Data Pilot 2020-04-11 08:48:25

Take a look to the deliverables list in detail:  detailed list of DEVINCI deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian Fernández-Otero, Carmen Streicher, Sebastian J Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marin
A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.51381
eLife 8 2020-04-11
2018 Lynette Lim, Da Mi, Alfredo Llorca, Oscar Marín
Development and Functional Diversification of Cortical Interneurons
published pages: 294-313, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.10.009
Neuron 100/2 2020-04-11
2019 Fong Kuan Wong, Oscar Marín
Developmental Cell Death in the Cerebral Cortex
published pages: 523-542, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-100818-125204
Annual Review of Cell and Developmental Biology 35/1 2020-04-11

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