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pBioStrat-for-PDA SIGNED

Use of PAP as a biomarker and stratifier of pancreatic cancer to improve patient management

Total Cost €

0

EC-Contrib. €

0

Partnership

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 pBioStrat-for-PDA project word cloud

Explore the words cloud of the pBioStrat-for-PDA project. It provides you a very rough idea of what is the project "pBioStrat-for-PDA" about.

clinical    chemotherapy    progresses    predict    pbiostrat    biomarker    understand    peri    candidates    context    pancreatic    nature    characterizing    improvements    invasive    incidence    starting    biological    patients    consequence    with    redirection    opened    limiting    serum    titration    erc    tumoral    tumor    conceptual    physiology    neglecting    fundamental    resectability    prognosis    shortening    2011    unnecessary    grant    stratify    microenvironment    optimization    jak2    cellular    solid    ductal    compartment    panr    worst    start    figures    acinar    palliative    consists    trials    neural    stromal    90    revealed    clinicians    morbidity    80    interestingly    managements    discoveries    invasion       signalling    potent    tool    negative    poc    secreted    cohorts    outlook    delay    stat3    criteria    reg3a    mortality    survival    constitutes    cancer    took    powerful    last    demonstrated    specificity    cells    pda    rate    trying    pap    2016    validation    adenocarcinoma    surgery    tumors   

Project "pBioStrat-for-PDA" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 150˙000.00

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 Project objective

With an overall 3-year survival rate of only ~6% together with an increased incidence pancreatic ductal adenocarcinoma (PDA), which represents 90% of pancreatic cancer, figures as the solid cancer with the worst prognosis. In trying to understand “the” reason for such negative outlook, one has to consider that the fundamental and clinical research conducted during the last 30 years has focused on characterizing and understanding the properties of the PDA cancer cells, neglecting the specific cellular context of those tumors. Indeed PDA consists of 80% of non-tumor cells. In the ERC Starting grant, S-Target-in-PANR, I conducted from 2011 to 2016 we took into account this specificity and analyzed the impact of this stromal compartment on PDA physiology. The discoveries and conceptual progresses obtained throughout the S-Target-in-PANR programme opened new potent improvements of PDA patients’ management. Among them, we revealed that one of the candidates, PAP/REG3A, was secreted by acinar cells from the peri-tumoral microenvironment to enhance peri-neural invasion ability of tumor cells. Interestingly, we demonstrated that PAP/REG3A titration in serum was a potent biomarker in order to stratify PDA and could lead to patients’ management optimization and more specifically to predict resectability. This validation, using robust cohorts and adapted testing, constitutes the main goal of our ERC-PoC pBioStrat-for-PDA. Indeed, it will provide a powerful tool for clinicians in order to better determine the resectability of a tumor by taking into account its biological nature on top of the only clinical criteria used so far. As a consequence the use of a non-invasive PAP/REG3A serum level determination will improve patients’ managements by (1) shortening the delay to start palliative chemotherapy, (2) limiting unnecessary surgery with important mortality/morbidity and (3) improving their redirection to adapted clinical trials, as the one targeting JAK2/STAT3 signalling.

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