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MolMacIP SIGNED

Molecular Machines with Integrated Parts

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MolMacIP" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 2˙471˙095 €
 EC max contribution 2˙471˙095 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 2˙471˙095.00

Map

 Project objective

The widespread use of molecular-level motion in key natural processes suggests that great rewards could come from bridging the gap between the present generation of synthetic molecular machines—which by and large rely upon switching of individual components to carry out their functions—and the machines of the macroscopic world, which utilize the synchronized behaviour of integrated components to perform tasks more complex than the sum of the components. The aim of this project is to learn how to integrate the movements and chemistries of different molecular machine components.

The proposed program is divided into three themes:

Theme 1: Transport and synthesis by nanomechanical substrate positioning. We will integrate switching mechanisms with components that can attach and release a substrate, in order to develop methodology for the nanomechanical manipulation of substrates. We see this theme as reminiscent of the way that substrates are passed between sites in various enzyme complexes in biology.

Theme 2: Sequence-selective synthesis using molecular assembly lines. We will integrate reactive molecular appendages with rotaxanes in which the macrocycle moves along a track through brownian motion, in order to develop molecular assembly lines. This theme is reminiscent of molecular-machine-mediated sequence specific polymerisation in biology, such as protein synthesis by the ribosome and DNA synthesis by some DNA polymerases.

Theme 3: Transport with chemically fuelled molecular linear motors. We shall integrate ratchet mechanisms with chemically fuelled molecular pumps and walkers and use them to transport cargo between phases and to carry out synthesis via energy ratchet mechanisms induced by chemical fuels. This theme is reminiscent of how biological molecular motors drive chemical systems away from equilibrium, thereby enabling tasks to be performed, cargo to be transported directionally and work to be done.

 Publications

year authors and title journal last update
List of publications.
2019 Chiara Biagini, Stephen D. P. Fielden, David A. Leigh, Fredrik Schaufelberger, Stefano Di Stefano, Dean Thomas
Dissipative Catalysis with a Molecular Machine
published pages: 9876-9880, ISSN: 1433-7851, DOI: 10.1002/anie.201905250
Angewandte Chemie International Edition 58/29 2019-10-30
2019 Javier Echavarren, Malcolm A. Y. Gall, Adrian Haertsch, David A. Leigh, Vanesa Marcos, Daniel J. Tetlow
Active template rotaxane synthesis through the Ni-catalyzed cross-coupling of alkylzinc reagents with redox-active esters
published pages: 7269-7273, ISSN: 2041-6520, DOI: 10.1039/c9sc02457c
Chemical Science 10/30 2019-10-28
2019 Jiankang Zhong, Liang Zhang, David P. August, George F. S. Whitehead, David A. Leigh
Self-Sorting Assembly of Molecular Trefoil Knots of Single Handedness
published pages: 14249-14256, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06127
Journal of the American Chemical Society 141/36 2019-10-28
2019 Marcel Dommaschk, Javier Echavarren, David A. Leigh, Vanesa Marcos, Thomas A. Singleton
Dynamic Control of Chiral Space Through Local Symmetry Breaking in a Rotaxane Organocatalyst
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201908330
Angewandte Chemie International Edition 2019-10-03

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