Opendata, web and dolomites


Biomolecule Sensing with Graphene-Integrated Nanogaps

Total Cost €


EC-Contrib. €






 BioGraphING project word cloud

Explore the words cloud of the BioGraphING project. It provides you a very rough idea of what is the project "BioGraphING" about.

final    device    temperature    bonds    free    exert    molecular    simulations    biophysics    function    room    plane    structure    transport    mechanically    offers    arrangement    electronics    thinness    individual    closely    mcbjs    resolution    distance    break    bonding    ideal    voltage    biomolecule    charge    junction    monitoring    diseases    bias    quantum    biographing    composition    pi    situ    electrode    superior    gap    degree    electronic    conductance    fingerprints    electrodes    inside    air    vacuum    sensitive    modes    label    single    species    modulations    mechanical    biological    nanoscopic    picometer    dna    combined    anchoring    environment    peptides    model    statistical    data    molecules    protein    functions    covalent    atomic    amino    mcbj    acids    sensing    junctions    origins    size    platform    trapping    cells    monitor    stability    molecule    graphene    tunnelling    spaced    caused    chemical    stacking    discriminate    biomolacular    contact    liquid    fingerprinting    architecture    inertness    first   

Project "BioGraphING" data sheet

The following table provides information about the project.


Organization address
address: STEVINWEG 1
city: DELFT
postcode: 2628 CN

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT DELFT NL (DELFT) coordinator 165˙598.00


 Project objective

Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level.

In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistical data analysis my final goal is to establish molecular fingerprints for amino acids and peptides with specific biological functions, an important challenge in single-molecule biophysics.


year authors and title journal last update
List of publications.
2018 Valentin Dubois, Shyamprasad N. Raja, Pascal Gehring, Sabina Caneva, Herre S. J. van der Zant, Frank Niklaus, Göran Stemme
Massively parallel fabrication of crack-defined gold break junctions featuring sub-3 nm gaps for molecular devices
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05785-2
Nature Communications 9/1 2020-03-23
2018 Sabina Caneva, Pascal Gehring, Víctor M. García-Suárez, Amador García-Fuente, Davide Stefani, Ignacio J. Olavarria-Contreras, Jaime Ferrer, Cees Dekker, Herre S. J. van der Zant
Mechanically controlled quantum interference in graphene break junctions
published pages: 1126-1131, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0258-0
Nature Nanotechnology 13/12 2020-03-23

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The information about "BIOGRAPHING" are provided by the European Opendata Portal: CORDIS opendata.

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