Explore the words cloud of the BioGraphING project. It provides you a very rough idea of what is the project "BioGraphING" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITEIT DELFT
|Coordinator Country||Netherlands [NL]|
|Total cost||165˙598 €|
|EC max contribution||165˙598 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-04-01 to 2020-03-31|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITEIT DELFT||NL (DELFT)||coordinator||165˙598.00|
Monitoring the DNA and protein composition of cells is key to understanding most biological processes, including the molecular origins of specific diseases. To this end, the emerging field of molecular electronics offers unique opportunities for label-free single-biomolecule sensing. In particular, tunnelling current modulations caused by trapping an individual molecule in a nanoscopic gap between two electrodes can be used to discriminate species based on their electronic structure. The junction conductance is highly sensitive not only to the structure of the molecule, but also to the gap size, the voltage applied, the bonding arrangement inside the gap and the immediate molecular environment. Mechanically controlled break junctions (MCBJs) that allow the formation of closely-spaced electrodes with picometer resolution, can exert a degree of control over each of these parameters and therefore represent an ideal platform for in-situ studies at single-molecule level.
In BioGraphING, I will develop the first graphene MCBJ, a unique device that will be both a model system for studying charge transport in molecular junctions at room temperature, and a sensing platform for biomolacular fingerprinting. Graphene’s atomic thinness, chemical inertness and strong in-plane bonds will lead to a device architecture with superior mechanical stability and measurement resolution. Given that a robust and reliable contact to single molecules is crucial for high junction conductance, various anchoring modes of the molecules to the graphene electrodes will be investigated (e.g. covalent bonding, π-π stacking). I will monitor the molecular conductance as a function of electrode distance and bias voltage in air, vacuum and in liquid. Combined with quantum transport simulations and statistical data analysis my final goal is to establish molecular fingerprints for amino acids and peptides with specific biological functions, an important challenge in single-molecule biophysics.
|year||authors and title||journal||last update|
Valentin Dubois, Shyamprasad N. Raja, Pascal Gehring, Sabina Caneva, Herre S. J. van der Zant, Frank Niklaus, GÃ¶ran Stemme
Massively parallel fabrication of crack-defined gold break junctions featuring sub-3â€‰nm gaps for molecular devices
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05785-2
|Nature Communications 9/1||2020-03-23|
Sabina Caneva, Pascal Gehring, VÃctor M. GarcÃa-SuÃ¡rez, Amador GarcÃa-Fuente, Davide Stefani, Ignacio J. Olavarria-Contreras, Jaime Ferrer, Cees Dekker, Herre S. J. van der Zant
Mechanically controlled quantum interference in graphene break junctions
published pages: 1126-1131, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0258-0
|Nature Nanotechnology 13/12||2020-03-23|
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The information about "BIOGRAPHING" are provided by the European Opendata Portal: CORDIS opendata.
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