Opendata, web and dolomites

ORGANITRA SIGNED

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ORGANITRA project word cloud

Explore the words cloud of the ORGANITRA project. It provides you a very rough idea of what is the project "ORGANITRA" about.

liposomes    newly    spectroscopies    fuel    nucleotides    binding    monitored    compounds    synthetic    membrane    phosphorylated    1h    synthesised    introduce    cross    dye    sensitive    combinatorial    metabolic    barriers    model    chemistry    compartments    encapsulated    organophosphates    efficient    connected    atp    ionic    templates    31p    signal    mechanism    performance    dependent    hydrazone    bilayer    emission    thiourea    enzymes    selectively    function    proteins    selective    species    transduction    building    anion    receptors    opening    blocks    cells    relevance    hydrophilic    containing    nmr    armed    libraries    biophysical    quenching    transmembrane    carriers    organic    assays    spectroscopy    nanoreactors    bonds    biologically    bind    dynamic    impermeable    borders    scaffolds    triphosphate    membranes    fluorescence    organitra    implicated    phosphate    character    elucidated    urea    additionally    aid    biotechnological    adenosine    lipid    groups    biochemical    transport    nucleotide   

Project "ORGANITRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙485˙274 €
 EC max contribution 1˙485˙274 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙485˙274.00

Map

 Project objective

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.

 Publications

year authors and title journal last update
List of publications.
2019 Glenn Grauwels, Hennie Valkenier, Anthony P. Davis, Ivan Jabin, Kristin Bartik
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
published pages: 6921-6925, ISSN: 1433-7851, DOI: 10.1002/anie.201900818
Angewandte Chemie International Edition 58/21 2019-11-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ORGANITRA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ORGANITRA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More