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ORGANITRA SIGNED

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ORGANITRA project word cloud

Explore the words cloud of the ORGANITRA project. It provides you a very rough idea of what is the project "ORGANITRA" about.

triphosphate    newly    assays    spectroscopies    introduce    phosphorylated    biotechnological    groups    cross    templates    libraries    signal    chemistry    organophosphates    binding    building    anion    dynamic    compartments    efficient    model    monitored    armed    ionic    spectroscopy    synthesised    bonds    aid    bilayer    containing    nanoreactors    encapsulated    biologically    transduction    quenching    phosphate    hydrazone    fluorescence    scaffolds    character    additionally    selective    dependent    barriers    selectively    combinatorial    metabolic    bind    opening    1h    atp    function    carriers    biochemical    sensitive    nmr    relevance    membrane    cells    mechanism    membranes    organic    dye    hydrophilic    borders    proteins    elucidated    connected    transport    nucleotides    nucleotide    impermeable    fuel    species    performance    adenosine    31p    blocks    receptors    emission    compounds    lipid    implicated    urea    transmembrane    biophysical    synthetic    thiourea    liposomes    organitra    enzymes   

Project "ORGANITRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙485˙274 €
 EC max contribution 1˙485˙274 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙485˙274.00

Map

 Project objective

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.

 Publications

year authors and title journal last update
List of publications.
2019 Glenn Grauwels, Hennie Valkenier, Anthony P. Davis, Ivan Jabin, Kristin Bartik
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
published pages: 6921-6925, ISSN: 1433-7851, DOI: 10.1002/anie.201900818
Angewandte Chemie International Edition 58/21 2019-11-13

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