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Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Total Cost €


EC-Contrib. €






 ORGANITRA project word cloud

Explore the words cloud of the ORGANITRA project. It provides you a very rough idea of what is the project "ORGANITRA" about.

metabolic    organitra    assays    1h    binding    organophosphates    species    hydrophilic    bind    sensitive    synthesised    groups    liposomes    dye    nucleotide    additionally    phosphate    transduction    aid    fluorescence    encapsulated    combinatorial    anion    function    character    nucleotides    transport    opening    membranes    connected    chemistry    hydrazone    membrane    templates    biologically    building    cross    urea    bonds    compartments    elucidated    receptors    synthetic    biophysical    performance    spectroscopy    mechanism    relevance    adenosine    proteins    scaffolds    compounds    implicated    containing    spectroscopies    31p    phosphorylated    signal    model    introduce    cells    lipid    impermeable    efficient    libraries    carriers    newly    bilayer    biochemical    emission    barriers    organic    borders    nmr    armed    fuel    ionic    triphosphate    enzymes    transmembrane    dynamic    selective    thiourea    dependent    selectively    blocks    atp    nanoreactors    monitored    quenching    biotechnological   

Project "ORGANITRA" data sheet

The following table provides information about the project.


Organization address
postcode: 1050

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙485˙274 €
 EC max contribution 1˙485˙274 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙485˙274.00


 Project objective

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.


year authors and title journal last update
List of publications.
2019 Glenn Grauwels, Hennie Valkenier, Anthony P. Davis, Ivan Jabin, Kristin Bartik
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
published pages: 6921-6925, ISSN: 1433-7851, DOI: 10.1002/anie.201900818
Angewandte Chemie International Edition 58/21 2019-11-13

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