Opendata, web and dolomites

ORGANITRA SIGNED

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ORGANITRA project word cloud

Explore the words cloud of the ORGANITRA project. It provides you a very rough idea of what is the project "ORGANITRA" about.

31p    proteins    carriers    implicated    performance    elucidated    efficient    quenching    hydrazone    encapsulated    ionic    connected    character    anion    model    templates    libraries    combinatorial    1h    biochemical    nucleotide    sensitive    hydrophilic    additionally    nanoreactors    opening    introduce    building    metabolic    enzymes    synthetic    transduction    cells    chemistry    bonds    synthesised    nmr    compounds    spectroscopy    dye    scaffolds    biologically    triphosphate    function    relevance    dependent    receptors    assays    adenosine    groups    mechanism    barriers    lipid    biophysical    species    newly    blocks    selective    membrane    aid    containing    emission    organic    fluorescence    organitra    monitored    spectroscopies    fuel    atp    armed    membranes    impermeable    organophosphates    bind    binding    transport    nucleotides    borders    compartments    dynamic    thiourea    cross    bilayer    transmembrane    phosphorylated    urea    biotechnological    signal    selectively    phosphate    liposomes   

Project "ORGANITRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙485˙274 €
 EC max contribution 1˙485˙274 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙485˙274.00

Map

 Project objective

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.

 Publications

year authors and title journal last update
List of publications.
2019 Glenn Grauwels, Hennie Valkenier, Anthony P. Davis, Ivan Jabin, Kristin Bartik
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
published pages: 6921-6925, ISSN: 1433-7851, DOI: 10.1002/anie.201900818
Angewandte Chemie International Edition 58/21 2019-11-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ORGANITRA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ORGANITRA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

TAMING CORROSION (2020)

Towards mastering the long-standing challenge of ageing infrastructures in corrosive environments

Read More