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ORGANITRA SIGNED

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ORGANITRA project word cloud

Explore the words cloud of the ORGANITRA project. It provides you a very rough idea of what is the project "ORGANITRA" about.

organic    ionic    phosphate    introduce    implicated    spectroscopy    opening    nucleotides    nmr    assays    scaffolds    libraries    organitra    lipid    selectively    cells    31p    anion    dye    additionally    aid    emission    borders    enzymes    hydrophilic    dynamic    synthetic    chemistry    biophysical    nucleotide    liposomes    model    cross    compounds    templates    compartments    phosphorylated    combinatorial    biologically    groups    organophosphates    adenosine    blocks    barriers    receptors    nanoreactors    membranes    metabolic    character    performance    efficient    thiourea    encapsulated    elucidated    fluorescence    function    connected    bonds    transport    membrane    monitored    fuel    urea    selective    containing    newly    building    hydrazone    biotechnological    impermeable    transmembrane    biochemical    atp    transduction    synthesised    triphosphate    dependent    sensitive    1h    armed    quenching    spectroscopies    signal    binding    bind    proteins    bilayer    relevance    mechanism    carriers    species   

Project "ORGANITRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LIBRE DE BRUXELLES 

Organization address
address: AVENUE FRANKLIN ROOSEVELT 50
city: BRUXELLES
postcode: 1050
website: www.ulb.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 1˙485˙274 €
 EC max contribution 1˙485˙274 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LIBRE DE BRUXELLES BE (BRUXELLES) coordinator 1˙485˙274.00

Map

 Project objective

This ORGANITRA project addresses transmembrane transport. Lipid bilayer membranes not only define the borders of cells and their compartments but are also implicated in metabolic processes and signal transduction. Membranes function as impermeable barriers for ionic and hydrophilic species which can only cross the membrane with the aid of dedicated membrane proteins. For biotechnological and biophysical applications, the development of anion carriers that can bind an anion and transport it across the lipid bilayer could be of great relevance. In this project, synthetic anion receptors will be developed to bind biologically relevant organic phosphorylated compounds, like nucleotides. These receptors will then be used to transport these organophosphates across membranes. The receptors will be synthesised by dynamic combinatorial chemistry. Building blocks containing urea or thiourea groups, for efficient phosphate binding, will be connected to multi-armed scaffolds by hydrazone groups. The dynamic character of these bonds will be used to identify efficient receptors from libraries of compounds, using different phosphorylated compounds as templates. With this approach, selective receptors for different nucleotides and related compounds can be obtained. The transport performance of the receptors will be evaluated with newly developed assays. Liposomes will be used as model systems and transport will be monitored by fluorescence spectroscopy using the quenching of the emission of an encapsulated phosphate sensitive dye. Additionally, the mechanism of the transport processes will be elucidated by fluorescence and 1H and 31P NMR spectroscopies. Transmembrane carriers for phosphorylated compounds will make it possible to selectively introduce nucleotides into liposomes and cells, opening the way to fuel enzymes with adenosine triphosphate (ATP) in liposomes as biotechnological nanoreactors and to study nucleotide-dependent biochemical processes in cells.

 Publications

year authors and title journal last update
List of publications.
2019 Glenn Grauwels, Hennie Valkenier, Anthony P. Davis, Ivan Jabin, Kristin Bartik
Repositioning Chloride Transmembrane Transporters: Transport of Organic Ion Pairs
published pages: 6921-6925, ISSN: 1433-7851, DOI: 10.1002/anie.201900818
Angewandte Chemie International Edition 58/21 2019-11-13

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