Opendata, web and dolomites

ImmunoCode SIGNED

Digital Single Cell Immunology: Decoding Cellular Interactions for Improved Immunotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ImmunoCode project word cloud

Explore the words cloud of the ImmunoCode project. It provides you a very rough idea of what is the project "ImmunoCode" about.

opportunity    minimal    metastatic    transcriptomics    inducing    decoding    technologies    infectious    vaccination    extremely    revolutionise    tight    differently    army    cancer    immunocode    erc    pairs    regulate    fact    ifns    unravel    cell    me    rare    patients    refining    pathogen    auto    pdc    strategies    induce    possess    swiss    pdcs    effector    balance    exploited    external    ctls    multitude    cytotoxic    function    vaccine    immune    poorly    human    longitudinally    innovative    roles    functions    immunity    dendritic    augmented    vaccines    heterogeneous    massive    shows    elusive    ultimately    risk    act    tumour    superior    microfluidic    environments    anti    secrete    population    interactions    functional    heterogeneity    tremendous    small    immunotherapy    battle    successful    diseases    platform    despite    influence    omission    single    specialized    subset    tolerance    prime    plasticity    plasmacytoid    immunology    remarkably    cellular    populations    exert    amounts    cells    knives   

Project "ImmunoCode" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙812˙143 €
 EC max contribution 1˙812˙143 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 1˙812˙143.00

Map

 Project objective

Successful immunotherapy against cancer is the result of a multitude of cellular interactions within the immune system. It is highly exciting how vaccination with small numbers of human plasmacytoid dendritic cells (pDCs) can induce anti-tumour immunity in metastatic cancer patients. Remarkably, how pDCs, as an extremely rare subset of cells, can act as Swiss army knives to regulate the tight balance between tolerance and immunity: i.e. secrete massive amounts of type I IFNs, prime T cells and exert cytotoxic effector functions, is still elusive. Do pDCs possess all functions or comprises the population distinct functional subsets all with their specialized roles. I will unravel which pDC is superior in inducing cytotoxic T cells (CTLs) for augmented cancer immunity. Despite advances in single cell technologies, understanding the role of heterogeneity in immune cell populations, remains poorly understood. In ImmunoCode, I will develop a novel and ambitious single cell technology platform, wherein innovative microfluidic approaches and single cell transcriptomics allow 1) functional analysis of single (pairs of) immune cells and 2) design of minimal environments under the omission of external factors that could influence cellular behaviour. This approach will provide me with the unique opportunity to unravel pDC function and plasticity. Although in this ERC proposal I will focus on understanding pDCs heterogeneity, my technology can in fact be exploited to any cell type that shows heterogeneous function. My unique and high-risk technical approach allows for decoding immune cell-cell or cell-pathogen interactions longitudinally and in great detail which will revolutionise the fields of immunology and cellular immunotherapy. Ultimately, ImmunoCode will have a tremendous impact by refining the design of vaccine strategies and the development of differently composed cellular vaccines to battle cancer and infectious and auto-immune diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNOCODE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNOCODE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENUF (2019)

Evaluation of Novel Ultra-Fast selective III-V Epitaxy

Read More  

PEGASOS (2019)

Photon Emitting Gated Arrays for Scalable On-chip quantum Systems

Read More  

Regen-membrane (2019)

Pulsed Electrophoretic Deposition to give Membranes for Regenerative Medicine

Read More