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Oral bacteria as determinants for respiratory health

Total Cost €


EC-Contrib. €






 BRuSH project word cloud

Explore the words cloud of the BRuSH project. It provides you a very rough idea of what is the project "BRuSH" about.

producing    synthesized    time    commensal    bronchial    functional    lipid    mice    population    models    drive    pathogens    asthmatic    dominated    host    sequences    effect    antagonistic    health    individuals    designed    bacterial    gain    induce    brush    programs    potent    balance    inflammatory    chemically    immune    cells    optimizing    microbiome    epidemiological    shown    relationship    disease    data    significance    lower    samples    assays    longitudinally    community    lungs    gateway    asthma    weak    cell    preventing    respiratory    lung    patients    tool    causal    assign    composition    dust    raw    hypothesis    epithelial    genome    pro    types    microbiota    annotation    lps    cluster    bacteria    prove    saliva    species    human    potency    intervention    dna    feasible    producers    play    periodontitis    function    bioinformatics    negative    communities    predict    lipopolysaccharide    tract    oral    healthy    cavity    exposing    gram    biological   

Project "BRuSH" data sheet

The following table provides information about the project.


Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙499˙938 €
 EC max contribution 1˙499˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 1˙499˙938.00


 Project objective

The oral cavity is the gateway to the lower respiratory tract, and oral bacteria are likely to play a role in lung health. This may be the case for pathogens as well as commensal bacteria and the balance between species. The oral bacterial community of patients with periodontitis is dominated by gram-negative bacteria and a higher lipopolysaccharide (LPS) activity than in healthy microbiota. Furthermore, bacteria with especially potent pro-inflammatory LPS have been shown to be more common in the lungs of asthmatic than in healthy individuals. The working hypothesis of BRuSH is that microbiome communities dominated by LPS-producing bacteria which induce a particularly strong pro-inflammatory immune response in the host, will have a negative effect on respiratory health. I will test this hypothesis in two longitudinally designed population-based lung health studies. I aim to identify whether specific bacterial composition and types of LPS producing bacteria in oral and dust samples predict lung function and respiratory health over time; and if the different types of LPS-producing bacteria affect LPS in saliva saliva and dust. BRuSH will apply functional genome annotation that can assign biological significance to raw bacterial DNA sequences. With this bioinformatics tool I will cluster microbiome data into various LPS-producers: bacteria with LPS with strong inflammatory effects and others with weak- or antagonistic effects. The epidemiological studies will be supported by mice-models of asthma and cell assays of human bronchial epithelial cells, by exposing mice and bronchial cells to chemically synthesized Lipid A (the component that drive the LPS-induced immune responses) of various potency. The goal of BRuSH is to prove a causal relationship between oral microbiome and lung health, and gain knowledge that will enable us to make oral health a feasible target for intervention programs aimed at optimizing lung health and preventing respiratory disease.

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The information about "BRUSH" are provided by the European Opendata Portal: CORDIS opendata.

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