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BRuSH SIGNED

Oral bacteria as determinants for respiratory health

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BRuSH project word cloud

Explore the words cloud of the BRuSH project. It provides you a very rough idea of what is the project "BRuSH" about.

asthma    microbiome    preventing    causal    producers    tract    gain    lung    individuals    disease    dna    play    relationship    data    programs    bioinformatics    predict    bacteria    population    potent    composition    intervention    dust    cell    healthy    asthmatic    patients    tool    cluster    prove    bacterial    gram    balance    models    negative    commensal    epidemiological    functional    epithelial    periodontitis    lps    oral    shown    health    microbiota    cavity    synthesized    brush    lipid    time    respiratory    bronchial    lower    designed    optimizing    communities    longitudinally    cells    pathogens    assays    types    saliva    genome    pro    community    lungs    annotation    effect    dominated    lipopolysaccharide    potency    gateway    inflammatory    immune    weak    host    sequences    hypothesis    species    exposing    assign    induce    antagonistic    raw    drive    human    producing    mice    function    chemically    samples    significance    biological    feasible   

Project "BRuSH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I BERGEN 

Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020
website: www.uib.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 1˙499˙938 €
 EC max contribution 1˙499˙938 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 1˙499˙938.00

Map

 Project objective

The oral cavity is the gateway to the lower respiratory tract, and oral bacteria are likely to play a role in lung health. This may be the case for pathogens as well as commensal bacteria and the balance between species. The oral bacterial community of patients with periodontitis is dominated by gram-negative bacteria and a higher lipopolysaccharide (LPS) activity than in healthy microbiota. Furthermore, bacteria with especially potent pro-inflammatory LPS have been shown to be more common in the lungs of asthmatic than in healthy individuals. The working hypothesis of BRuSH is that microbiome communities dominated by LPS-producing bacteria which induce a particularly strong pro-inflammatory immune response in the host, will have a negative effect on respiratory health. I will test this hypothesis in two longitudinally designed population-based lung health studies. I aim to identify whether specific bacterial composition and types of LPS producing bacteria in oral and dust samples predict lung function and respiratory health over time; and if the different types of LPS-producing bacteria affect LPS in saliva saliva and dust. BRuSH will apply functional genome annotation that can assign biological significance to raw bacterial DNA sequences. With this bioinformatics tool I will cluster microbiome data into various LPS-producers: bacteria with LPS with strong inflammatory effects and others with weak- or antagonistic effects. The epidemiological studies will be supported by mice-models of asthma and cell assays of human bronchial epithelial cells, by exposing mice and bronchial cells to chemically synthesized Lipid A (the component that drive the LPS-induced immune responses) of various potency. The goal of BRuSH is to prove a causal relationship between oral microbiome and lung health, and gain knowledge that will enable us to make oral health a feasible target for intervention programs aimed at optimizing lung health and preventing respiratory disease.

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The information about "BRUSH" are provided by the European Opendata Portal: CORDIS opendata.

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