Opendata, web and dolomites

MIAMi SIGNED

Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MIAMi project word cloud

Explore the words cloud of the MIAMi project. It provides you a very rough idea of what is the project "MIAMi" about.

medicines    sops    mias    environmental    miami    automated    excellent    plant    pharmaceutically    mia    parts    expression    risks    human    health    supervised    dna    leads    precursor    chemicals    microbial    psychosis    characterisation    cell    cancer    prototype    millennia    public    designs    alkaloids    algorithms    monoterpenoid    inventory    sectorial    plants    interdisciplinary    benefit    bioengineering    refactoring    data    tabersonine    treat    potent    industry    market    cellular    rauwolscine    cad    standardisation    standardised    structural    sustainable    biosynthetic    gt    omics    environment    sub    indole    gene    discovery    genetically    localisation    sampled    protein    founded    genome    therapies    bio    strictosidine    interactions    benefits    remarkable    engineering    drug    showcase    chains    inter    diversity    secondary    trackable    biological    nature    treatment    valuable    illnesses    biotech    compartmentalised    elucidated    metabolites    commercially    repository    producing    therapeutics    bioactivity    factories    represented    alstonine    yeast    learning   

Project "MIAMi" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 6˙648˙301 €
 EC max contribution 6˙648˙301 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙438˙313.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙511˙371.00
3    UNIVERSITE DE TOURS FR (TOURS) participant 1˙165˙125.00
4    FUTURE GENOMICS TECHNOLOGIES BV NL (LEIDEN) participant 853˙750.00
5    EXPLORA SRL IT (ROMA) participant 719˙250.00
6    AXYNTIS FR (PARIS) participant 619˙375.00
7    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 341˙116.00
8    JOHN INNES CENTRE UK (NORWICH) participant 0.00

Map

 Project objective

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.

 Publications

year authors and title journal last update
List of publications.
2020 Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Identifying Missing Biosynthesis Enzymes of Plant Natural Products
published pages: , ISSN: 0165-6147, DOI: 10.1016/j.tips.2019.12.006
Trends in Pharmacological Sciences 2020-02-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MIAMI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MIAMI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.2.1.4.)

SHIKIFACTORY100 (2019)

Modular cell factories for the production of 100 compounds from the shikimate pathway

Read More  

BioRoboost (2018)

Fostering Synthetic Biology standardisation through international collaboration

Read More  

BioICEP (2020)

Bio Innovation of a Circular Economy for Plastics

Read More