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MIAMi SIGNED

Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Total Cost €

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EC-Contrib. €

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Partnership

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MIAMi project word cloud

Explore the words cloud of the MIAMi project. It provides you a very rough idea of what is the project "MIAMi" about.

illnesses precursor market bio refactoring rauwolscine psychosis producing nature expression learning alkaloids plants sustainable therapeutics parts showcase genome pharmaceutically gene automated mias bioengineering cancer biosynthetic bioactivity algorithms standardisation compartmentalised chains prototype commercially structural cellular protein excellent benefit plant strictosidine sops genetically risks alstonine inter health treat cad founded sectorial potent designs biotech standardised interactions data treatment indole characterisation inventory gt benefits diversity monoterpenoid yeast tabersonine therapies drug environmental secondary millennia leads public localisation sampled chemicals supervised miami metabolites omics elucidated factories human represented interdisciplinary repository medicines dna microbial industry engineering cell discovery valuable environment sub trackable remarkable biological mia

Project "MIAMi" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	6˙648˙301 €
EC max contribution	6˙648˙301 € (100%)
Programme	1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
Code Call	H2020-NMBP-BIO-2018-two-stage
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	1˙438˙313.00
2	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	1˙511˙371.00
3	UNIVERSITE DE TOURS UNIVERSITE DE TOURS Organization address address: RUE DU PLAT D ETAIN 60 city: TOURS postcode: 37020 website: www.univ-tours.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOURS)	participant	1˙165˙125.00
4	FUTURE GENOMICS TECHNOLOGIES BV FUTURE GENOMICS TECHNOLOGIES BV Organization address address: SYLVIUSWEG 74 city: LEIDEN postcode: 2333 BE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	853˙750.00
5	EXPLORA SRL EXPLORA SRL Organization address address: Via Giacomo Peroni 386 city: ROMA postcode: 131 website: www.explora-biotech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	719˙250.00
6	AXYNTIS AXYNTIS Organization address address: 45 RUE DE POMMARD city: PARIS postcode: 75012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	619˙375.00
7	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	341˙116.00
8	JOHN INNES CENTRE JOHN INNES CENTRE Organization address address: NORWICH RESEARCH PARK COLNEY city: NORWICH postcode: NR4 7UH website: www.jic.bbsrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	participant	0.00

Map

Project objective

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.

Publications

List of publications.
year	authors and title	journal	last update
2020	Thomas DugÃ© de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. Oâ€™Connor, Vincent Courdavault Identifying Missing Biosynthesis Enzymes of Plant Natural Products published pages: , ISSN: 0165-6147, DOI: 10.1016/j.tips.2019.12.006	Trends in Pharmacological Sciences	2020-02-20

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