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MIAMi SIGNED

Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Total Cost €

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EC-Contrib. €

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Partnership

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 MIAMi project word cloud

Explore the words cloud of the MIAMi project. It provides you a very rough idea of what is the project "MIAMi" about.

excellent    inter    miami    benefits    health    inventory    commercially    expression    showcase    potent    treat    interdisciplinary    biotech    benefit    mia    discovery    treatment    drug    biosynthetic    sops    producing    environment    parts    yeast    supervised    engineering    indole    tabersonine    human    cancer    remarkable    elucidated    learning    bio    standardised    market    compartmentalised    bioengineering    characterisation    psychosis    sub    public    illnesses    environmental    cellular    microbial    medicines    automated    standardisation    therapies    chains    biological    gene    algorithms    represented    monoterpenoid    protein    pharmaceutically    factories    sampled    founded    secondary    dna    plants    sustainable    precursor    designs    prototype    interactions    mias    nature    alkaloids    gt    refactoring    cell    genome    therapeutics    sectorial    industry    structural    valuable    strictosidine    rauwolscine    bioactivity    plant    diversity    alstonine    omics    genetically    metabolites    trackable    data    repository    millennia    chemicals    cad    risks    leads    localisation   

Project "MIAMi" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 6˙648˙301 €
 EC max contribution 6˙648˙301 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙438˙313.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙511˙371.00
3    UNIVERSITE DE TOURS FR (TOURS) participant 1˙165˙125.00
4    FUTURE GENOMICS TECHNOLOGIES BV NL (LEIDEN) participant 853˙750.00
5    EXPLORA SRL IT (ROMA) participant 719˙250.00
6    AXYNTIS FR (PARIS) participant 619˙375.00
7    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 341˙116.00
8    JOHN INNES CENTRE UK (NORWICH) participant 0.00

Map

 Project objective

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.

 Publications

year authors and title journal last update
List of publications.
2020 Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Identifying Missing Biosynthesis Enzymes of Plant Natural Products
published pages: , ISSN: 0165-6147, DOI: 10.1016/j.tips.2019.12.006
Trends in Pharmacological Sciences 2020-02-20

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The information about "MIAMI" are provided by the European Opendata Portal: CORDIS opendata.

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