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MIAMi SIGNED

Refactoring monoterpenoid indole alkaloid production in microbial cell factories

Total Cost €

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EC-Contrib. €

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Partnership

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 MIAMi project word cloud

Explore the words cloud of the MIAMi project. It provides you a very rough idea of what is the project "MIAMi" about.

illnesses    precursor    market    bio    refactoring    rauwolscine    psychosis    producing    nature    expression    learning    alkaloids    plants    sustainable    therapeutics    parts    showcase    genome    pharmaceutically    gene    automated    mias    bioengineering    cancer    biosynthetic    bioactivity    algorithms    standardisation    compartmentalised    chains    prototype    commercially    structural    cellular    protein    excellent    benefit    plant    strictosidine    sops    genetically    risks    alstonine    inter    health    treat    cad    founded    sectorial    potent    designs    biotech    standardised    interactions    data    treatment    indole    characterisation    inventory    gt    benefits    diversity    monoterpenoid    yeast    tabersonine    therapies    drug    environmental    secondary    millennia    leads    public    localisation    sampled    chemicals    supervised    miami    metabolites    omics    elucidated    factories    human    represented    interdisciplinary    repository    medicines    dna    microbial    industry    engineering    cell    discovery    valuable    environment    sub    trackable    remarkable    biological    mia   

Project "MIAMi" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 6˙648˙301 €
 EC max contribution 6˙648˙301 € (100%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-NMBP-BIO-2018-two-stage
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 1˙438˙313.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙511˙371.00
3    UNIVERSITE DE TOURS FR (TOURS) participant 1˙165˙125.00
4    FUTURE GENOMICS TECHNOLOGIES BV NL (LEIDEN) participant 853˙750.00
5    EXPLORA SRL IT (ROMA) participant 719˙250.00
6    AXYNTIS FR (PARIS) participant 619˙375.00
7    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 341˙116.00
8    JOHN INNES CENTRE UK (NORWICH) participant 0.00

Map

 Project objective

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to produce both commercially available and new-to-market MIAs rauwolscine, tabersonine and alstonine in yeast, and finally test their bioactivity as new cancer and psychosis treatment drug leads.

 Publications

year authors and title journal last update
List of publications.
2020 Thomas Dugé de Bernonville, Nicolas Papon, Marc Clastre, Sarah E. O’Connor, Vincent Courdavault
Identifying Missing Biosynthesis Enzymes of Plant Natural Products
published pages: , ISSN: 0165-6147, DOI: 10.1016/j.tips.2019.12.006
Trends in Pharmacological Sciences 2020-02-20

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