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Homo.symbiosus SIGNED

Assessing, preserving and restoring man-microbes symbiosis

Total Cost €

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EC-Contrib. €

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Partnership

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 Homo.symbiosus project word cloud

Explore the words cloud of the Homo.symbiosus project. It provides you a very rough idea of what is the project "Homo.symbiosus" about.

alternative    robustness    ecological    modalities    era    preventive    revolution    immune    mediated    transitions    insights    assemble    prone    latter    break    dysbiosis    symptoms    incurable    validate    acting    signals    health    symbiosis    personalized    favoured    true    alone    stable    aggravating    recognition    points    dysbiotic    therapeutic    ecology    individualized    theoretical    birth    balanced    derive    cohort    experimental    evolution    applies    diet    holobiont    reinforce    tipping    clinical    organ    gut    concomitantly    lifestyles    context    paradigm    population    incidence    circles    care    nutritional    earth    disease    preclinical    therapeutics    critical    trials    grounds    nutrition    diseases    quantitative    functional    transition    attitudes    host    societies    carry    microbiomics    auto    crosstalk    interactions    counter    challenged    geared    model    considering    fraction    threat    alleviation    restore    co    entered    contributions    tentatively    ing    microbes    altered    environmental    species    modern    strategies    predictors    microbiome    man    triggers    shift    vicious    human   

Project "Homo.symbiosus" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙491˙014 €
 EC max contribution 2˙491˙014 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 2˙491˙014.00

Map

 Project objective

The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbiome and host features with auto-aggravating crosstalk signals. The result is increased incidence of incurable immune-mediated diseases of modern societies that affect a third the human population on earth today and for which current therapeutics only address symptoms alleviation, rather than considering man as a holobiont. In this context and its resulting threat for the human species, I will carry out a project geared to open a new era of individualized preventive care and novel gut ecology-based therapeutic approaches. The project will assemble insights and contributions from theoretical to experimental ecology, quantitative and functional microbiomics, preclinical work, cohort studies and clinical trials, so as to: • Validate the concept of critical transition and alternative stable state as it applies to a shift from man-microbes symbiosis to disease-prone man-microbes dysbiosis • Assess the potential of diet alone to promote such a shift • Model the symbiosis-to-dysbiosis transitions and derive predictors of tipping points • Propose counter-measures that may allow to break vicious circles and restore a balanced, health-prone, man-microbes symbiosis by concomitantly acting upon microbiome and host features • Validate strategies to reinforce ecological robustness and restore man-microbes symbiosis Based on a paradigm shift, the proposed work will set the grounds for future personalized preventive nutrition and clinical management considering man as a true holobiont.

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The information about "HOMO.SYMBIOSUS" are provided by the European Opendata Portal: CORDIS opendata.

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