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Homo.symbiosus SIGNED

Assessing, preserving and restoring man-microbes symbiosis

Total Cost €

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EC-Contrib. €

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Partnership

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 Homo.symbiosus project word cloud

Explore the words cloud of the Homo.symbiosus project. It provides you a very rough idea of what is the project "Homo.symbiosus" about.

critical    preventive    auto    contributions    co    strategies    recognition    crosstalk    holobiont    alone    quantitative    tentatively    tipping    geared    man    vicious    diet    points    dysbiosis    trials    grounds    microbes    signals    transition    diseases    ing    aggravating    immune    cohort    considering    triggers    break    latter    shift    predictors    altered    health    entered    societies    therapeutic    derive    population    carry    incurable    alleviation    acting    theoretical    modalities    reinforce    interactions    revolution    counter    experimental    circles    era    paradigm    lifestyles    incidence    microbiome    prone    mediated    model    clinical    therapeutics    human    host    ecology    robustness    microbiomics    disease    attitudes    symbiosis    assemble    context    care    insights    organ    favoured    personalized    validate    functional    challenged    evolution    true    modern    nutrition    applies    dysbiotic    transitions    gut    ecological    birth    fraction    nutritional    threat    symptoms    earth    species    environmental    balanced    concomitantly    alternative    stable    preclinical    restore    individualized   

Project "Homo.symbiosus" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT 

Organization address
address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338
website: www.inra.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙491˙014 €
 EC max contribution 2˙491˙014 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT FR (PARIS CEDEX 07) coordinator 2˙491˙014.00

Map

 Project objective

The microbiomics revolution has favoured the recognition of the gut as a true organ and the importance of man-microbes symbiosis in health and disease. Derived from a long co-evolution the latter has been challenged by numerous environmental triggers, modern lifestyles, changes in birth modalities, nutritional transition and therapeutic attitudes. A large fraction of the human population has tentatively entered a man-microbes dysbiotic state characterized by altered interactions between microbiome and host features with auto-aggravating crosstalk signals. The result is increased incidence of incurable immune-mediated diseases of modern societies that affect a third the human population on earth today and for which current therapeutics only address symptoms alleviation, rather than considering man as a holobiont. In this context and its resulting threat for the human species, I will carry out a project geared to open a new era of individualized preventive care and novel gut ecology-based therapeutic approaches. The project will assemble insights and contributions from theoretical to experimental ecology, quantitative and functional microbiomics, preclinical work, cohort studies and clinical trials, so as to: • Validate the concept of critical transition and alternative stable state as it applies to a shift from man-microbes symbiosis to disease-prone man-microbes dysbiosis • Assess the potential of diet alone to promote such a shift • Model the symbiosis-to-dysbiosis transitions and derive predictors of tipping points • Propose counter-measures that may allow to break vicious circles and restore a balanced, health-prone, man-microbes symbiosis by concomitantly acting upon microbiome and host features • Validate strategies to reinforce ecological robustness and restore man-microbes symbiosis Based on a paradigm shift, the proposed work will set the grounds for future personalized preventive nutrition and clinical management considering man as a true holobiont.

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The information about "HOMO.SYMBIOSUS" are provided by the European Opendata Portal: CORDIS opendata.

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