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DYNAP SIGNED

Dynamic Penetrating Peptide Adaptamers

Total Cost €

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EC-Contrib. €

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Partnership

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 DYNAP project word cloud

Explore the words cloud of the DYNAP project. It provides you a very rough idea of what is the project "DYNAP" about.

viral    structural    environmentally    strategies    instability    shake    positioned    supramolecular    cell    penetrating    technologies    transfection    signalling    strategy    appropriate    molecules    biocompatible    groups    clickable    precisely    hyperthermia    aldehydes    labelling    adaptamers    discoveries    drugs    membrane    biophysical    sensitive    govern    topological    hydrazide    advantages    epitoping    ligands    techniques    resolve    drug    additionally    chemistry    peptide    chemotherapy    synthetic    ing    platforms    formulation    collections    selective    translocation    biomimetic    adaptive    reversible    protein    limitations    transport    suffer    therapy    covalent    gene    self    systematically    dynamic    peptides    toxicity    fluorescent    pattern    explored    afford    transporters    biology    reagents    molecular    protease    bond    organelles    drawbacks    secondary    specificity    despite    lack    synthesise    motifs    scaffolds    enormous    digestion    cells    structure    tissues    versatility    hinder    transfecting    efficient    recognition    minimal    conjugated    multivalent    synthesis    therapeutic    probes   

Project "DYNAP" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA 

Organization address
address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
city: SANTIAGO DE COMPOSTELA
postcode: 15782
website: http://www.usc.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.javiermontenegrochemistry.com
 Total cost 1˙492˙525 €
 EC max contribution 1˙492˙525 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) coordinator 1˙492˙525.00

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 Project objective

The aim of this proposal is to identify, at the molecular level, the minimal topological and structural motifs that govern the membrane translocation of short peptides. A covalent reversible bond strategy will be developed for the synthesis of self-adaptive penetrating peptides (adaptamers) for targeted delivery.

It is known that the recently developed therapeutic technologies (i.e. gene therapy, chemotherapy, hyperthermia, etc.) cannot reach their expected potential due to limitations in the current delivery strategies, which hinder the efficient targeting of the appropriate tissues, cells and organelles. Despite the enormous therapeutic potential of short penetrating peptides, these molecules suffer from drawbacks such as toxicity, instability to protease digestion and lack of specificity.

Dynamic covalent chemistry has significant synthetic advantages. In the proposed research, peptide scaffolds with clickable reversible groups (e.g. hydrazide) will be conjugated with collections of aldehydes to afford self-adaptive biomimetic transporters, whose secondary structure and penetrating properties will be systematically characterized by biophysical, cell-biology and pattern recognition techniques.

The versatility of dynamic supramolecular “peptide adaptamers” with precisely positioned protein ligands will be explored for multivalent specific recognition, protein transport, cell targeting of drugs and probes and membrane epitoping.

Additionally, we propose to synthesise dynamic and environmentally sensitive fluorescent probes for biocompatible membrane labelling and uptake signalling.

The resulting discoveries of this research will allow the formulation of novel transfecting reagents for gene therapy, selective platforms for drug-delivery and the development of dynamic fluorescent membrane probes. The potential results of this proposal will shake the fields of drug-delivery and non-viral gene transfection and will resolve the limitations of the current approaches.

 Publications

year authors and title journal last update
List of publications.
2018 Marisa Juanes, Irene Lostalé-Seijo, Juan R. Granja, Javier Montenegro
Supramolecular Recognition and Selective Protein Uptake by Peptide Hybrids
published pages: 10689-10698, ISSN: 0947-6539, DOI: 10.1002/chem.201800706
Chemistry - A European Journal 24/42 2020-03-20
2018 Javier Montenegro, José Reina, Alicia Rioboo
Glycosyl Aldehydes: New Scaffolds for the Synthesis of Neoglycoconjugates via Bioorthogonal Oxime Bond Formation
published pages: 831-845, ISSN: 0039-7881, DOI: 10.1055/s-0036-1591082
Synthesis 50/04 2020-03-20
2018 Alejandro Méndez-Ardoy, Juan R. Granja, Javier Montenegro
pH-Triggered self-assembly and hydrogelation of cyclic peptide nanotubes confined in water micro-droplets
published pages: 391-396, ISSN: 2055-6756, DOI: 10.1039/c8nh00009c
Nanoscale Horizons 3/4 2020-03-20
2018 J. Fernández-Rosas, Marcia Pessêgo, Angel Acuña, Carlos Vázquez-Vázquez, Javier Montenegro, Mercedes Parajó, Pedro Rodríguez-Dafonte, Faruk Nome, Luis Garcia-Rio
Novel Supramolecular Nanoparticles Derived from Cucurbit[7]uril and Zwitterionic Surfactants
published pages: 3485-3493, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.7b04234
Langmuir 34/11 2020-03-20
2017 Javier Montenegro, Robert J. Phipps
Highlights from the 52nd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2017
published pages: 9960-9966, ISSN: 1359-7345, DOI: 10.1039/c7cc90258a
Chemical Communications 53/72 2020-03-20
2018 Alejandro Méndez Ardoy, Irene Lostalé-Seijo, Javier Montenegro
Where in the cell is our cargo? Current methods to study intracellular cytosolic localization.
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201800390
ChemBioChem 2020-03-20
2018 Marta Pazo, Marisa Juanes, Irene Lostalé-Seijo, Javier Montenegro
Oligoalanine helical callipers for cell penetration
published pages: 6919-6922, ISSN: 1359-7345, DOI: 10.1039/c8cc02304b
Chemical Communications 54/50 2020-03-20
2017 Irene Lostalé-Seijo, Iria Louzao, Marisa Juanes, Javier Montenegro
Peptide/Cas9 nanostructures for ribonucleoprotein cell membrane transport and gene edition
published pages: 7923-7931, ISSN: 2041-6520, DOI: 10.1039/c7sc03918b
Chemical Science 8/12 2020-03-20
2019 Ivan Gallego, Alicia Rioboo, Jose J Reina, Bernardo Díaz, Ángeles Canales, F Javier Cañada, Jorge Guerra-Varela, Laura Sánchez, Javier Montenegro
Glycosylated Cell Penetrating Peptides, GCPPs
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201800720
ChemBioChem 2020-03-20
2019 Richard Booth, Ignacio Insua, Ghibom Bhak, Javier Montenegro
Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles
published pages: 1984-1991, ISSN: 1477-0520, DOI: 10.1039/C8OB02243G
Organic & Biomolecular Chemistry 17/7 2020-03-20
2018 Irene Lostalé-Seijo, Javier Montenegro
Synthetic materials at the forefront of gene delivery
published pages: 258-277, ISSN: 2397-3358, DOI: 10.1038/s41570-018-0039-1
Nature Reviews Chemistry 2/10 2020-03-20
2017 Javier Montenegro, Marta Pazo, Héctor Fernández-Caro, Juan Priegue, Irene Lostalé-Seijo
Tuning the Properties of Penetrating Peptides by Oxime Conjugation
published pages: 924-928, ISSN: 0936-5214, DOI: 10.1055/s-0036-1588689
Synlett 28/08 2020-03-20
2017 Alberto Fuertes, Marisa Juanes, Juan R. Granja, Javier Montenegro
Supramolecular functional assemblies: dynamic membrane transporters and peptide nanotubular composites
published pages: 7861-7871, ISSN: 1359-7345, DOI: 10.1039/C7CC02997G
Chem. Commun. 53/56 2020-03-20
2017 Iria Louzao, Rebeca García-Fandiño, Javier Montenegro
Hydrazone-modulated peptides for efficient gene transfection
published pages: 4426-4434, ISSN: 2050-7518, DOI: 10.1039/C7TB00179G
J. Mater. Chem. B 5/23 2020-03-20
2017 Daniel N. Crisan, Oliver Creese, Ranadeb Ball, Jose Luis Brioso, Ben Martyn, Javier Montenegro, Francisco Fernandez-Trillo
Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification
published pages: 4576-4584, ISSN: 1759-9954, DOI: 10.1039/C7PY00535K
Polym. Chem. 8/31 2020-03-20
2016 Juan M. Priegue, Daniel N. Crisan, José Martínez-Costas, Juan R. Granja, Francisco Fernandez-Trillo, Javier Montenegro
In Situ Functionalized Polymers for siRNA Delivery
published pages: 7492-7495, ISSN: 1433-7851, DOI: 10.1002/anie.201601441
Angewandte Chemie International Edition 55/26 2020-03-20

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