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Deciphering the host and microbial grounds that license inflammasome-mediated execution

Total Cost €


EC-Contrib. €






 INFLAME project word cloud

Explore the words cloud of the INFLAME project. It provides you a very rough idea of what is the project "INFLAME" about.

genome    visual    unsuspected    crispr    pro    molecular    expertise    inflammatory    sensors    paradigms    cytosolic    ligands    caspase    microbial    unravel    gasdermins    forming    immunology    automated    parts    gasdermin    directed    activation    functions    cytokines    bases    regulators    beta    multidisciplinary    nucleate    effectors    unprecedented    cell    sensing       canonical    interleukin    immune    breakthroughs    unexplored    necrosis    models    combination    therapies    maturation    diseases    throughput    protein    regulated    building    coupling    unbiased    release    inflammasomes    pathogens    il    proteins    vivo    infections    inflammasome    screening    cas9    18    infectious    auto    play    mediate    induce    biochemistry    entirely    search    pyroptosis    dependent    disorders    components    protease    host    interferon    inducible    detection    immunity    biology    innovative    angles    intracellular    technologies    proteases    vitro    complexes   

Project "INFLAME" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙799 €
 EC max contribution 1˙498˙799 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Inflammasomes are intracellular multi-protein complexes that play essential functions in immunity against microbial pathogens. Upon microbial sensing, inflammasomes induce protease caspase-1-dependent maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as gasdermin-D-dependent cell necrosis, namely pyroptosis. While both pyroptosis and IL-1β/IL-18 release play key parts in controlling microbial infections, the host-regulated pathways that promote detection of microbial ligands by cytosolic inflammasome-forming sensors and the non-canonical functions of inflammasome-derived components, remain to be fully characterized.

Building on my expertise in the field of inflammasome regulators during microbial infections, I propose to study several key, yet unexplored aspects of the functions of inflammasomes in immunity from different angles. In particular, I propose to 1/ identify and characterize new host interferon-inducible factors that mediate microbial sensing by the inflammasomes, and 2/ unravel new non-canonical functions of inflammasome-derived proteases and gasdermins. To address these issues, I will use a combination of state-of-the-art and innovative technologies in biochemistry, molecular and cell biology, and immunology in various in vitro and in vivo models. For example, I propose to develop an unbiased genome-wide search for novel effectors involved in inflammasome activation based on the unprecedented coupling of the CRISPR-Cas9 technology to automated visual high-throughput screening.

This multidisciplinary proposal will provide breakthroughs in the field of microbial pathogens detection by the host immune system, and will nucleate entirely novel immune paradigms on microbial sensing by new unsuspected host cytosolic proteins, namely the gasdermins. The results of this project will also provide strong bases for building innovative host-directed therapies for auto-inflammatory disorders and infectious diseases.

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The information about "INFLAME" are provided by the European Opendata Portal: CORDIS opendata.

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