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Opendata, web and dolomites

INFLAME SIGNED

Deciphering the host and microbial grounds that license inflammasome-mediated execution

Total Cost €

EC-Contrib. €

Partnership

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INFLAME project word cloud

Explore the words cloud of the INFLAME project. It provides you a very rough idea of what is the project "INFLAME" about.

effectors therapies visual paradigms building mediate gasdermin dependent 18 cytosolic genome cell regulated beta components cytokines auto canonical il 1 diseases interferon proteases unexplored expertise activation unbiased maturation proteins caspase forming parts gasdermins sensors biology directed combination biochemistry entirely protease automated play unprecedented molecular innovative necrosis angles cas9 inflammatory throughput complexes release models vivo protein unravel regulators induce immunity immune immunology inflammasomes pyroptosis disorders infectious microbial intracellular host search unsuspected functions detection multidisciplinary ligands inflammasome pathogens sensing inducible breakthroughs vitro bases pro infections technologies interleukin nucleate crispr screening coupling

Project "INFLAME" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	1˙498˙799 €
EC max contribution	1˙498˙799 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-12-01 to 2023-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙498˙799.00

Map

Project objective

Inflammasomes are intracellular multi-protein complexes that play essential functions in immunity against microbial pathogens. Upon microbial sensing, inflammasomes induce protease caspase-1-dependent maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as gasdermin-D-dependent cell necrosis, namely pyroptosis. While both pyroptosis and IL-1β/IL-18 release play key parts in controlling microbial infections, the host-regulated pathways that promote detection of microbial ligands by cytosolic inflammasome-forming sensors and the non-canonical functions of inflammasome-derived components, remain to be fully characterized.

Building on my expertise in the field of inflammasome regulators during microbial infections, I propose to study several key, yet unexplored aspects of the functions of inflammasomes in immunity from different angles. In particular, I propose to 1/ identify and characterize new host interferon-inducible factors that mediate microbial sensing by the inflammasomes, and 2/ unravel new non-canonical functions of inflammasome-derived proteases and gasdermins. To address these issues, I will use a combination of state-of-the-art and innovative technologies in biochemistry, molecular and cell biology, and immunology in various in vitro and in vivo models. For example, I propose to develop an unbiased genome-wide search for novel effectors involved in inflammasome activation based on the unprecedented coupling of the CRISPR-Cas9 technology to automated visual high-throughput screening.

This multidisciplinary proposal will provide breakthroughs in the field of microbial pathogens detection by the host immune system, and will nucleate entirely novel immune paradigms on microbial sensing by new unsuspected host cytosolic proteins, namely the gasdermins. The results of this project will also provide strong bases for building innovative host-directed therapies for auto-inflammatory disorders and infectious diseases.

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The information about "INFLAME" are provided by the European Opendata Portal: CORDIS opendata.