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INFLAME SIGNED

Deciphering the host and microbial grounds that license inflammasome-mediated execution

Total Cost €

0

EC-Contrib. €

0

Partnership

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 INFLAME project word cloud

Explore the words cloud of the INFLAME project. It provides you a very rough idea of what is the project "INFLAME" about.

innovative    regulators    host    forming    interleukin    screening    automated    bases    microbial    therapies    sensors    nucleate    beta    il    paradigms    functions    cytokines    intracellular    auto    gasdermin       building    inflammatory    expertise    pro    release    technologies    pyroptosis    inducible    unsuspected    infectious    unravel    biology    regulated    genome    vitro    diseases    molecular    complexes    sensing    dependent    unbiased    activation    protein    protease    maturation    biochemistry    necrosis    pathogens    detection    canonical    mediate    18    combination    effectors    models    unexplored    throughput    proteases    play    disorders    visual    cell    ligands    entirely    cas9    immunity    components    directed    infections    crispr    immune    inflammasomes    unprecedented    proteins    coupling    caspase    immunology    interferon    cytosolic    gasdermins    angles    breakthroughs    inflammasome    induce    parts    search    multidisciplinary    vivo   

Project "INFLAME" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙799 €
 EC max contribution 1˙498˙799 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙498˙799.00

Map

 Project objective

Inflammasomes are intracellular multi-protein complexes that play essential functions in immunity against microbial pathogens. Upon microbial sensing, inflammasomes induce protease caspase-1-dependent maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as gasdermin-D-dependent cell necrosis, namely pyroptosis. While both pyroptosis and IL-1β/IL-18 release play key parts in controlling microbial infections, the host-regulated pathways that promote detection of microbial ligands by cytosolic inflammasome-forming sensors and the non-canonical functions of inflammasome-derived components, remain to be fully characterized.

Building on my expertise in the field of inflammasome regulators during microbial infections, I propose to study several key, yet unexplored aspects of the functions of inflammasomes in immunity from different angles. In particular, I propose to 1/ identify and characterize new host interferon-inducible factors that mediate microbial sensing by the inflammasomes, and 2/ unravel new non-canonical functions of inflammasome-derived proteases and gasdermins. To address these issues, I will use a combination of state-of-the-art and innovative technologies in biochemistry, molecular and cell biology, and immunology in various in vitro and in vivo models. For example, I propose to develop an unbiased genome-wide search for novel effectors involved in inflammasome activation based on the unprecedented coupling of the CRISPR-Cas9 technology to automated visual high-throughput screening.

This multidisciplinary proposal will provide breakthroughs in the field of microbial pathogens detection by the host immune system, and will nucleate entirely novel immune paradigms on microbial sensing by new unsuspected host cytosolic proteins, namely the gasdermins. The results of this project will also provide strong bases for building innovative host-directed therapies for auto-inflammatory disorders and infectious diseases.

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The information about "INFLAME" are provided by the European Opendata Portal: CORDIS opendata.

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