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INFLAME SIGNED

Deciphering the host and microbial grounds that license inflammasome-mediated execution

Total Cost €

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EC-Contrib. €

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Partnership

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 INFLAME project word cloud

Explore the words cloud of the INFLAME project. It provides you a very rough idea of what is the project "INFLAME" about.

regulated    inducible    maturation    cytosolic    pro    crispr    visual    therapies    immunity    activation    parts    inflammasomes    unravel    technologies    forming    biochemistry    angles    throughput    cell    microbial    screening    detection    sensing    vitro    infectious    play    bases    18    combination    unbiased    pathogens    nucleate    protease    building    immunology    mediate    ligands    effectors    components    regulators    cas9    proteins    coupling    induce    sensors    unsuspected    unexplored    directed    innovative    pyroptosis    dependent    genome    infections    beta    canonical    entirely    unprecedented    expertise    breakthroughs    gasdermin    search    release    biology    gasdermins    auto    molecular    multidisciplinary       host    functions    models    diseases    inflammasome    paradigms    protein    intracellular    il    inflammatory    automated    necrosis    vivo    proteases    interferon    immune    caspase    disorders    cytokines    complexes    interleukin   

Project "INFLAME" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙498˙799 €
 EC max contribution 1˙498˙799 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙498˙799.00

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 Project objective

Inflammasomes are intracellular multi-protein complexes that play essential functions in immunity against microbial pathogens. Upon microbial sensing, inflammasomes induce protease caspase-1-dependent maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 as well as gasdermin-D-dependent cell necrosis, namely pyroptosis. While both pyroptosis and IL-1β/IL-18 release play key parts in controlling microbial infections, the host-regulated pathways that promote detection of microbial ligands by cytosolic inflammasome-forming sensors and the non-canonical functions of inflammasome-derived components, remain to be fully characterized.

Building on my expertise in the field of inflammasome regulators during microbial infections, I propose to study several key, yet unexplored aspects of the functions of inflammasomes in immunity from different angles. In particular, I propose to 1/ identify and characterize new host interferon-inducible factors that mediate microbial sensing by the inflammasomes, and 2/ unravel new non-canonical functions of inflammasome-derived proteases and gasdermins. To address these issues, I will use a combination of state-of-the-art and innovative technologies in biochemistry, molecular and cell biology, and immunology in various in vitro and in vivo models. For example, I propose to develop an unbiased genome-wide search for novel effectors involved in inflammasome activation based on the unprecedented coupling of the CRISPR-Cas9 technology to automated visual high-throughput screening.

This multidisciplinary proposal will provide breakthroughs in the field of microbial pathogens detection by the host immune system, and will nucleate entirely novel immune paradigms on microbial sensing by new unsuspected host cytosolic proteins, namely the gasdermins. The results of this project will also provide strong bases for building innovative host-directed therapies for auto-inflammatory disorders and infectious diseases.

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The information about "INFLAME" are provided by the European Opendata Portal: CORDIS opendata.

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