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3D-nanoMorph SIGNED

Label-free 3D morphological nanoscopy for studying sub-cellular dynamics in live cancer cells with high spatio-temporal resolution

Total Cost €

EC-Contrib. €

Partnership

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3D-nanoMorph project word cloud

Explore the words cloud of the 3D-nanoMorph project. It provides you a very rough idea of what is the project "3D-nanoMorph" about.

label light opens sub employs expertise nanoscale live possibilities spatial disciplinary innovatively temporal optical diffraction computational photobleaching avenues biological microscopy harnessing breaks algorithm isotropic spanning imaging autophagy complementary decodes linear electromagnetism first mapping nanomorph cross cells organelles structures time free nanoscopy resolution intensity barrier degradation 3d scattering lack yielding cancer nm cell cellular labels presently enhancement paves photochemical collection toxicity morphological successful illumination create extended treatment fluorescence perspective limited performs fresh shifts organelle inverse optics showcase 14 devises roles paradigm lt

Project "3D-nanoMorph" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET Organization address address: HANSINE HANSENS VEG 14 city: TROMSO postcode: 9019 website: http://uit.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Total cost	1˙499˙999 €
EC max contribution	1˙499˙999 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-07-01 to 2024-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET Organization address address: HANSINE HANSENS VEG 14 city: TROMSO postcode: 9019 website: http://uit.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TROMSO)	coordinator	1˙499˙999.00

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Project objective

Label-free optical nanoscopy, free from photobleaching and photochemical toxicity of fluorescence labels and yielding 3D morphological resolution of <50 nm, is the future of live cell imaging. 3D-nanoMorph breaks the diffraction barrier and shifts the paradigm in label-free nanoscopy, providing isotropic 3D resolution of <50 nm. To achieve this, 3D-nanoMorph performs non-linear inverse scattering for the first time in nanoscopy and decodes scattering between sub-cellular structures (organelles).

3D-nanoMorph innovatively devises complementary roles of light measurement system and computational nanoscopy algorithm. A novel illumination system and a novel light collection system together enable measurement of only the most relevant intensity component and create a fresh perspective about label-free measurements. A new computational nanoscopy approach employs non-linear inverse scattering. Harnessing non-linear inverse scattering for resolution enhancement in nanoscopy opens new possibilities in label-free 3D nanoscopy.

I will apply 3D-nanoMorph to study organelle degradation (autophagy) in live cancer cells over extended duration with high spatial and temporal resolution, presently limited by the lack of high-resolution label-free 3D morphological nanoscopy. Successful 3D mapping of nanoscale biological process of autophagy will open new avenues for cancer treatment and showcase 3D-nanoMorph for wider applications.

My cross-disciplinary expertise of 14 years spanning inverse problems, electromagnetism, optical microscopy, integrated optics and live cell nanoscopy paves path for successful implementation of 3D-nanoMorph.

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The information about "3D-NANOMORPH" are provided by the European Opendata Portal: CORDIS opendata.