EU H2020 Project "ARTHEP (Hepatocytes-Like Microreactors for Liver Tissue Engineering)": description, partecipants, costs and EC-fundings

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ArtHep project word cloud

Explore the words cloud of the ArtHep project. It provides you a very rough idea of what is the project "ArtHep" about.

live microreactors pressure biocatalytic mechanical counteract hepatic obtain medical mimicking surface cues bioprinted perform fatty damage matured demand liver epidemics changing foundation transplanted rats assembly consolidating encapsulation synthetic criteria camouflaging am ex ground match disease connection obesity cell subunits transplant reduce damaged global causing entities opportunity transplants cells matching career scientific convinced coating regeneration game donor functions core purposes carriers science mimics micro insufficient enzyme biological biomimicry grow arthep breaking destined mimic angled dimensions environment shortage conversions structure abundancy progress unexplored tissue slowing alcoholic moving vivo efforts excellence engineering connect active anticipated consisting lobules diabetes organs entirely

Project "ArtHep" data sheet

The following table provides information about the project.

Coordinator	AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Total cost	1˙992˙289 €
EC max contribution	1˙992˙289 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-COG
Funding Scheme	ERC-COG
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2024-04-30

#	participants	country	role	EC contrib. [€]
1	AARHUS UNIVERSITET	DK (AARHUS C)	coordinator	1˙992˙289.00

AARHUS UNIVERSITET

DK (AARHUS C)

coordinator

1˙992˙289.00

Project objective

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.

ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.

Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.

I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.

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The information about "ARTHEP" are provided by the European Opendata Portal: CORDIS opendata.

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