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ArtHep SIGNED

Hepatocytes-Like Microreactors for Liver Tissue Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ArtHep project word cloud

Explore the words cloud of the ArtHep project. It provides you a very rough idea of what is the project "ArtHep" about.

mimics    microreactors    biocatalytic    environment    synthetic    mimicking    changing    subunits    global    opportunity    surface    micro    lobules    arthep    cues    epidemics    organs    hepatic    purposes    moving    functions    counteract    insufficient    liver    bioprinted    camouflaging    destined    cell    ex    live    fatty    assembly    shortage    convinced    regeneration    consolidating    slowing    tissue    dimensions    excellence    biological    biomimicry    abundancy    cells    transplants    unexplored    breaking    entirely    grow    medical    scientific    demand    transplant    am    foundation    perform    mimic    alcoholic    game    connect    engineering    obesity    matching    encapsulation    core    reduce    criteria    damage    causing    transplanted    donor    rats    pressure    angled    connection    damaged    vivo    progress    obtain    ground    consisting    conversions    matured    science    structure    anticipated    mechanical    match    career    coating    entities    enzyme    disease    carriers    active    efforts    diabetes   

Project "ArtHep" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙992˙289 €
 EC max contribution 1˙992˙289 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2024-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙992˙289.00

Map

 Project objective

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.

ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.

Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.

I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving them forward into unexplored dimensions in biomimicry for medical purposes, is a unique opportunity to advance my career.

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The information about "ARTHEP" are provided by the European Opendata Portal: CORDIS opendata.

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