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MEFISTO SIGNED

MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Total Cost €

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EC-Contrib. €

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Partnership

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 MEFISTO project word cloud

Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.

clinical    metal    vital    joint    compartment    strategy    active    osteoarthritis    social    post    predict    vascularized    reflecting    avascular    ing    inner    substitutes    articular    nanobiomaterials    meniscus    patient    modulation    act    scaffold    lies    strategies    receiving    epidemic    leaving    interact    zone    prosthesis    technological    benefits    nanoparticles    oa    revascularization    risk    bioactive    clear    mefisto    tissues    inflammation    solutions    socio    regenerate    capacity    meniscectomy    burden    innovation    reconstructive    degeneration    economic    drug    preventing    biodegradable    meniscal    levels    native    population    undergone    sacrificing    younger    peripheral    profiling    healthcare    functionalized    biologically    complete    device    tissue    functionalization    micro    modulate    resection    undergo    morbidity    patients    interventions    knee    reducing    whilst    surrounding    osteoarthritic    inflammatory    onset    unloading    personalized    efficacy    treat    mechanical    prevent    environment    morphological   

Project "MEFISTO" data sheet

The following table provides information about the project.

Coordinator
GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH 

Organization address
address: SCHNEIDWEG 5
city: BADEN-BADEN
postcode: 76534
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙996˙590 €
 EC max contribution 5˙996˙590 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH DE (BADEN-BADEN) coordinator 361˙250.00
2    ACTIVE IMPLANTS BV NL (HAARLEM) participant 852˙762.00
3    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 847˙375.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 559˙442.00
5    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 543˙750.00
6    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 498˙562.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 482˙197.00
8    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 461˙875.00
9    TISSUE CLICK LTD UK (BRIGHTON) participant 381˙250.00
10    SCIPROM SARL CH (SAINT SULPICE) participant 290˙000.00
11    ORTHOKEY ITALIA SRL IT (CARRARA MS) participant 253˙125.00
12    AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING DE (LORRACH) participant 248˙125.00
13    ETABLISSEMENT FRANCAIS DU SANG FR (LA PLAINE SAINT DENIS) participant 216˙875.00

Map

 Project objective

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.

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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.

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