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MEFISTO SIGNED

MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Total Cost €

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EC-Contrib. €

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Partnership

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 MEFISTO project word cloud

Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.

zone    efficacy    capacity    mechanical    innovation    modulation    unloading    patients    bioactive    morbidity    reconstructive    regenerate    biodegradable    strategies    oa    meniscectomy    functionalized    onset    articular    burden    functionalization    receiving    social    profiling    leaving    morphological    metal    reflecting    tissues    drug    personalized    whilst    biologically    modulate    meniscal    active    degeneration    inner    avascular    scaffold    act    reducing    epidemic    compartment    post    nanobiomaterials    substitutes    environment    younger    patient    joint    complete    levels    risk    osteoarthritic    micro    osteoarthritis    prevent    interventions    vascularized    nanoparticles    treat    socio    predict    preventing    technological    ing    vital    tissue    economic    native    healthcare    interact    population    sacrificing    revascularization    knee    strategy    inflammation    prosthesis    clear    inflammatory    clinical    meniscus    undergone    peripheral    lies    solutions    surrounding    mefisto    undergo    device    benefits    resection   

Project "MEFISTO" data sheet

The following table provides information about the project.

Coordinator
GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH 

Organization address
address: SCHNEIDWEG 5
city: BADEN-BADEN
postcode: 76534
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙996˙590 €
 EC max contribution 5˙996˙590 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH DE (BADEN-BADEN) coordinator 361˙250.00
2    ACTIVE IMPLANTS BV NL (HAARLEM) participant 852˙762.00
3    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 847˙375.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 559˙442.00
5    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 543˙750.00
6    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 498˙562.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 482˙197.00
8    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 461˙875.00
9    TISSUE CLICK LTD UK (BRIGHTON) participant 381˙250.00
10    SCIPROM SARL CH (SAINT SULPICE) participant 290˙000.00
11    ORTHOKEY ITALIA SRL IT (CARRARA MS) participant 253˙125.00
12    AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING DE (LORRACH) participant 248˙125.00
13    ETABLISSEMENT FRANCAIS DU SANG FR (LA PLAINE SAINT DENIS) participant 216˙875.00

Map

 Project objective

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.

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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.

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