MEFISTO SIGNED
MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy
Total Cost €
0EC-Contrib. €
0Partnership
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0MEFISTO project word cloud
Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.
Project "MEFISTO" data sheet
The following table provides information about the project.
| Coordinator |
GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 5˙996˙590 € |
| EC max contribution | 5˙996˙590 € (100%) |
| Programme |
1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies) |
| Code Call | H2020-NMBP-TR-IND-2018 |
| Funding Scheme | RIA |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-04-01 to 2023-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH | DE (BADEN-BADEN) | coordinator | 361˙250.00 |
| 2 | ACTIVE IMPLANTS BV | NL (HAARLEM) | participant | 852˙762.00 |
| 3 | HUMANITAS UNIVERSITY | IT (PIEVE EMANUELE) | participant | 847˙375.00 |
| 4 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | participant | 559˙442.00 |
| 5 | KLINIKUM DER UNIVERSITAET REGENSBURG | DE (REGENSBURG) | participant | 543˙750.00 |
| 6 | UNIVERSITEIT ANTWERPEN | BE (ANTWERPEN) | participant | 498˙562.00 |
| 7 | UNIVERSIDAD DE SANTIAGO DE COMPOSTELA | ES (SANTIAGO DE COMPOSTELA) | participant | 482˙197.00 |
| 8 | CONSIGLIO NAZIONALE DELLE RICERCHE | IT (ROMA) | participant | 461˙875.00 |
| 9 | TISSUE CLICK LTD | UK (BRIGHTON) | participant | 381˙250.00 |
| 10 | SCIPROM SARL | CH (SAINT SULPICE) | participant | 290˙000.00 |
| 11 | ORTHOKEY ITALIA SRL | IT (CARRARA MS) | participant | 253˙125.00 |
| 12 | AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING | DE (LORRACH) | participant | 248˙125.00 |
| 13 | ETABLISSEMENT FRANCAIS DU SANG | FR (LA PLAINE SAINT DENIS) | participant | 216˙875.00 |
Map
Project objective
MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.
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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.