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MEFISTO SIGNED

MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Total Cost €

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EC-Contrib. €

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Partnership

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 MEFISTO project word cloud

Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.

efficacy    receiving    meniscectomy    sacrificing    osteoarthritis    osteoarthritic    joint    surrounding    vascularized    preventing    articular    socio    epidemic    degeneration    resection    clear    undergone    benefits    active    predict    nanoparticles    peripheral    profiling    post    knee    prosthesis    scaffold    technological    vital    regenerate    nanobiomaterials    functionalized    leaving    tissues    inflammation    mefisto    reconstructive    unloading    clinical    environment    burden    complete    functionalization    compartment    drug    substitutes    biodegradable    solutions    act    whilst    morbidity    patients    younger    meniscal    reducing    undergo    tissue    interact    strategy    capacity    lies    native    meniscus    micro    device    inner    innovation    reflecting    population    modulate    morphological    revascularization    risk    modulation    interventions    oa    biologically    metal    social    zone    ing    patient    strategies    mechanical    levels    inflammatory    bioactive    avascular    economic    healthcare    treat    prevent    personalized    onset   

Project "MEFISTO" data sheet

The following table provides information about the project.

Coordinator
GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH 

Organization address
address: SCHNEIDWEG 5
city: BADEN-BADEN
postcode: 76534
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙996˙590 €
 EC max contribution 5˙996˙590 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH DE (BADEN-BADEN) coordinator 361˙250.00
2    ACTIVE IMPLANTS BV NL (HAARLEM) participant 852˙762.00
3    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 847˙375.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 559˙442.00
5    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 543˙750.00
6    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 498˙562.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 482˙197.00
8    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 461˙875.00
9    TISSUE CLICK LTD UK (BRIGHTON) participant 381˙250.00
10    SCIPROM SARL CH (SAINT SULPICE) participant 290˙000.00
11    ORTHOKEY ITALIA SRL IT (CARRARA MS) participant 253˙125.00
12    AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING DE (LORRACH) participant 248˙125.00
13    ETABLISSEMENT FRANCAIS DU SANG FR (LA PLAINE SAINT DENIS) participant 216˙875.00

Map

 Project objective

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.

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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.

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