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MEFISTO SIGNED

MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Total Cost €

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EC-Contrib. €

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Partnership

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 MEFISTO project word cloud

Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.

oa    whilst    regenerate    benefits    peripheral    meniscal    metal    prosthesis    burden    modulation    healthcare    nanobiomaterials    vascularized    prevent    population    capacity    socio    nanoparticles    scaffold    articular    lies    vital    biologically    sacrificing    native    leaving    undergo    preventing    tissues    strategy    device    levels    act    predict    unloading    patient    post    osteoarthritis    inner    receiving    osteoarthritic    meniscectomy    reflecting    ing    joint    mechanical    inflammation    undergone    reconstructive    social    strategies    active    patients    surrounding    drug    bioactive    complete    interventions    resection    degeneration    environment    economic    functionalized    micro    personalized    profiling    treat    clear    younger    epidemic    avascular    technological    knee    onset    tissue    biodegradable    interact    compartment    revascularization    mefisto    morbidity    innovation    zone    clinical    morphological    modulate    efficacy    reducing    inflammatory    functionalization    meniscus    risk    substitutes    solutions   

Project "MEFISTO" data sheet

The following table provides information about the project.

Coordinator
GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH 

Organization address
address: SCHNEIDWEG 5
city: BADEN-BADEN
postcode: 76534
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 5˙996˙590 €
 EC max contribution 5˙996˙590 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-TR-IND-2018
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH DE (BADEN-BADEN) coordinator 361˙250.00
2    ACTIVE IMPLANTS BV NL (HAARLEM) participant 852˙762.00
3    HUMANITAS UNIVERSITY IT (PIEVE EMANUELE) participant 847˙375.00
4    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) participant 559˙442.00
5    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) participant 543˙750.00
6    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) participant 498˙562.00
7    UNIVERSIDAD DE SANTIAGO DE COMPOSTELA ES (SANTIAGO DE COMPOSTELA) participant 482˙197.00
8    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 461˙875.00
9    TISSUE CLICK LTD UK (BRIGHTON) participant 381˙250.00
10    SCIPROM SARL CH (SAINT SULPICE) participant 290˙000.00
11    ORTHOKEY ITALIA SRL IT (CARRARA MS) participant 253˙125.00
12    AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING DE (LORRACH) participant 248˙125.00
13    ETABLISSEMENT FRANCAIS DU SANG FR (LA PLAINE SAINT DENIS) participant 216˙875.00

Map

 Project objective

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.

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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.

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